FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037524143> ?p ?o ?g. }

• W3037524143 abstract "ABSTRACT Rationale Pneumonia is a respiratory condition with complex aetiology. Host genetic variation is thought to contribute to individual differences in susceptibility and symptom manifestation. Methods We analysed pneumonia data from the UK Biobank (14,780 cases and 439,096 controls) and FinnGen (9,980 cases and 86,519 controls). We perform genome-wide association study (GWAS) meta-analysis, gene-based test, colocalisation, genetic correlation, latent causal variable and polygenic prediction in an independent Australian sample (N=5,595) to draw insights into the genetic aetiology of pneumonia risk. Results We identify two independent loci on chromosome 15 (lead SNPs rs2009746 and rs76474922) to be associated with pneumonia(p<5e-8). Gene-based tests revealed eighteen genes in chromosomes 15,16 and 9, including IL127, PBX3, APOBR and smoking related genes CHRNA3/5 , associated with pneumonia. Evidence of HYKK and PBX3 involvement in pneumonia risk was supported by eQTL colocalisation analysis. We observed genetic correlations between pneumonia and cardiorespiratory, psychiatric and inflammatory related traits. Latent causal variable analysis suggests a strong genetic causal relationship cardiovascular health phenotypes and pneumonia risk. Polygenic risk scores (PRS) for pneumonia significantly predicted self-reported pneumonia history in an independent Australian sample, albeit with a small effect size (OR=1.11 95%CI=[1.04-1.19], p<0.05). Sensitivity analyses suggested the associations in chromosome 15 are mediated by smoking history, but the association of genes in chromosome 16 and 9, and polygenic prediction were robust to adjustment for smoking. Conclusions Altogether, our results highlight common genetic variants, genes and potential pathways that contribute to individual differences in susceptibility to pneumonia, and advance our understanding of the genetic factors underlying heterogeneity in respiratory medical outcomes." @default.
• W3037524143 created "2020-07-02" @default.
• W3037524143 creator A5003567367 @default.
• W3037524143 creator A5010775510 @default.
• W3037524143 creator A5018398870 @default.
• W3037524143 creator A5035890150 @default.
• W3037524143 creator A5040788603 @default.
• W3037524143 creator A5066194292 @default.
• W3037524143 creator A5066568424 @default.
• W3037524143 date "2020-06-24" @default.
• W3037524143 modified "2023-10-17" @default.
• W3037524143 title "Genetic susceptibility to pneumonia: A GWAS meta-analysis between UK Biobank and FinnGen" @default.
• W3037524143 cites W1757314322 @default.
• W3037524143 cites W2003832429 @default.
• W3037524143 cites W2009444355 @default.
• W3037524143 cites W2018991776 @default.
• W3037524143 cites W2022464860 @default.
• W3037524143 cites W2024773717 @default.
• W3037524143 cites W2064066776 @default.
• W3037524143 cites W2069633622 @default.
• W3037524143 cites W2077958173 @default.
• W3037524143 cites W2108344795 @default.
• W3037524143 cites W2118822739 @default.
• W3037524143 cites W2121074186 @default.
• W3037524143 cites W2121756063 @default.
• W3037524143 cites W2123704730 @default.
• W3037524143 cites W2133440505 @default.
• W3037524143 cites W2153158159 @default.
• W3037524143 cites W2163605326 @default.
• W3037524143 cites W2165962540 @default.
• W3037524143 cites W2325607383 @default.
• W3037524143 cites W2514447495 @default.
• W3037524143 cites W2606773284 @default.
• W3037524143 cites W2612427157 @default.
• W3037524143 cites W2770902410 @default.
• W3037524143 cites W2774875239 @default.
• W3037524143 cites W2803504232 @default.
• W3037524143 cites W2904538417 @default.
• W3037524143 cites W2909233955 @default.
• W3037524143 cites W2909598358 @default.
• W3037524143 cites W2943666761 @default.
• W3037524143 cites W2950958620 @default.
• W3037524143 cites W2957752804 @default.
• W3037524143 cites W2991899552 @default.
• W3037524143 cites W2995245946 @default.
• W3037524143 cites W3007273493 @default.
• W3037524143 cites W3011798551 @default.
• W3037524143 cites W3013527652 @default.
• W3037524143 cites W3020501430 @default.
• W3037524143 doi "https://doi.org/10.1101/2020.06.22.20103556" @default.
• W3037524143 hasPublicationYear "2020" @default.
• W3037524143 type Work @default.
• W3037524143 sameAs 3037524143 @default.
• W3037524143 citedByCount "4" @default.
• W3037524143 countsByYear W30375241432021 @default.
• W3037524143 countsByYear W30375241432022 @default.
• W3037524143 crossrefType "posted-content" @default.
• W3037524143 hasAuthorship W3037524143A5003567367 @default.
• W3037524143 hasAuthorship W3037524143A5010775510 @default.
• W3037524143 hasAuthorship W3037524143A5018398870 @default.
• W3037524143 hasAuthorship W3037524143A5035890150 @default.
• W3037524143 hasAuthorship W3037524143A5040788603 @default.
• W3037524143 hasAuthorship W3037524143A5066194292 @default.
• W3037524143 hasAuthorship W3037524143A5066568424 @default.
• W3037524143 hasBestOaLocation W30375241431 @default.
• W3037524143 hasConcept C104317684 @default.
• W3037524143 hasConcept C106208931 @default.
• W3037524143 hasConcept C116567970 @default.
• W3037524143 hasConcept C126322002 @default.
• W3037524143 hasConcept C135763542 @default.
• W3037524143 hasConcept C137627325 @default.
• W3037524143 hasConcept C153209595 @default.
• W3037524143 hasConcept C186413461 @default.
• W3037524143 hasConcept C2777914695 @default.
• W3037524143 hasConcept C54355233 @default.
• W3037524143 hasConcept C71924100 @default.
• W3037524143 hasConcept C86803240 @default.
• W3037524143 hasConceptScore W3037524143C104317684 @default.
• W3037524143 hasConceptScore W3037524143C106208931 @default.
• W3037524143 hasConceptScore W3037524143C116567970 @default.
• W3037524143 hasConceptScore W3037524143C126322002 @default.
• W3037524143 hasConceptScore W3037524143C135763542 @default.
• W3037524143 hasConceptScore W3037524143C137627325 @default.
• W3037524143 hasConceptScore W3037524143C153209595 @default.
• W3037524143 hasConceptScore W3037524143C186413461 @default.
• W3037524143 hasConceptScore W3037524143C2777914695 @default.
• W3037524143 hasConceptScore W3037524143C54355233 @default.
• W3037524143 hasConceptScore W3037524143C71924100 @default.
• W3037524143 hasConceptScore W3037524143C86803240 @default.
• W3037524143 hasLocation W30375241431 @default.
• W3037524143 hasOpenAccess W3037524143 @default.
• W3037524143 hasPrimaryLocation W30375241431 @default.
• W3037524143 hasRelatedWork W1998237698 @default.
• W3037524143 hasRelatedWork W2145474755 @default.
• W3037524143 hasRelatedWork W2169993638 @default.
• W3037524143 hasRelatedWork W2730428919 @default.
• W3037524143 hasRelatedWork W286307657 @default.
• W3037524143 hasRelatedWork W2884987722 @default.
• W3037524143 hasRelatedWork W2917883050 @default.
• W3037524143 hasRelatedWork W2953466646 @default.

• next