Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037536204> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W3037536204 endingPage "516" @default.
- W3037536204 startingPage "506" @default.
- W3037536204 abstract "Abstract The TRAF family member-associated nuclear factor (NF)-κB activator (TANK) was first identified as a TRAF-binding protein with both stimulatory and inhibitory properties in host innate immune activation. To elucidate the roles of TANK in teleosts, we cloned and characterized the TANK homologue of orange-spotted grouper (Epinephelus coioides). The open reading frame (ORF) of EcTANK consists of 1026 nucleotides encoding a 342 amino acid protein with a predicted molecular mass of 38.24 kDa. EcTANK shares 89.47% and 88.89% identity with Larimichthys crocea TANK and Lates calcarifer TANK, respectively. EcTANK was distributed in all 11 examined tissues. The expression of EcTANK in the spleen increased after infection with Singapore grouper iridovirus (SGIV) and red-spotted grouper nervous necrosis virus (RGNNV). EcTANK was mainly located in the cytoplasm of grouper spleen cells. EcTANK enhanced SGIV and RGNNV replication during viral infection in vitro. Overexpression EcTANK decreased the expression levels of interferon-associated cytokines and pro-inflammatory factors, and enhanced activation of NF-κB. Taken together, these results suggest that EcTANK may play an important role in antiviral innate immune activation in grouper." @default.
- W3037536204 created "2020-07-02" @default.
- W3037536204 creator A5003176186 @default.
- W3037536204 creator A5006651636 @default.
- W3037536204 creator A5032447166 @default.
- W3037536204 creator A5056416947 @default.
- W3037536204 creator A5059808573 @default.
- W3037536204 creator A5077201932 @default.
- W3037536204 date "2020-09-01" @default.
- W3037536204 modified "2023-09-27" @default.
- W3037536204 title "The roles of grouper TANK in innate immune defense against iridovirus and nodavirus infections" @default.
- W3037536204 cites W1519841129 @default.
- W3037536204 cites W1992550177 @default.
- W3037536204 cites W2005845622 @default.
- W3037536204 cites W2017598982 @default.
- W3037536204 cites W2025026731 @default.
- W3037536204 cites W2027998343 @default.
- W3037536204 cites W2036528355 @default.
- W3037536204 cites W2042292146 @default.
- W3037536204 cites W2053276356 @default.
- W3037536204 cites W2053622417 @default.
- W3037536204 cites W2084880831 @default.
- W3037536204 cites W2089394364 @default.
- W3037536204 cites W2089651572 @default.
- W3037536204 cites W2091479071 @default.
- W3037536204 cites W2115832922 @default.
- W3037536204 cites W2126887217 @default.
- W3037536204 cites W2127520526 @default.
- W3037536204 cites W2147140524 @default.
- W3037536204 cites W2155763709 @default.
- W3037536204 cites W2172063500 @default.
- W3037536204 cites W2196802541 @default.
- W3037536204 cites W2550493286 @default.
- W3037536204 cites W2585994988 @default.
- W3037536204 cites W2760290374 @default.
- W3037536204 cites W2883874207 @default.
- W3037536204 cites W2898441138 @default.
- W3037536204 cites W2924619340 @default.
- W3037536204 cites W2944744218 @default.
- W3037536204 cites W2971481509 @default.
- W3037536204 doi "https://doi.org/10.1016/j.fsi.2020.06.017" @default.
- W3037536204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32585359" @default.
- W3037536204 hasPublicationYear "2020" @default.
- W3037536204 type Work @default.
- W3037536204 sameAs 3037536204 @default.
- W3037536204 citedByCount "2" @default.
- W3037536204 countsByYear W30375362042021 @default.
- W3037536204 countsByYear W30375362042022 @default.
- W3037536204 crossrefType "journal-article" @default.
- W3037536204 hasAuthorship W3037536204A5003176186 @default.
- W3037536204 hasAuthorship W3037536204A5006651636 @default.
- W3037536204 hasAuthorship W3037536204A5032447166 @default.
- W3037536204 hasAuthorship W3037536204A5056416947 @default.
- W3037536204 hasAuthorship W3037536204A5059808573 @default.
- W3037536204 hasAuthorship W3037536204A5077201932 @default.
- W3037536204 hasConcept C136449434 @default.
- W3037536204 hasConcept C159047783 @default.
- W3037536204 hasConcept C203014093 @default.
- W3037536204 hasConcept C2522874641 @default.
- W3037536204 hasConcept C2778967481 @default.
- W3037536204 hasConcept C2909208804 @default.
- W3037536204 hasConcept C2909396630 @default.
- W3037536204 hasConcept C505870484 @default.
- W3037536204 hasConcept C86803240 @default.
- W3037536204 hasConcept C8891405 @default.
- W3037536204 hasConceptScore W3037536204C136449434 @default.
- W3037536204 hasConceptScore W3037536204C159047783 @default.
- W3037536204 hasConceptScore W3037536204C203014093 @default.
- W3037536204 hasConceptScore W3037536204C2522874641 @default.
- W3037536204 hasConceptScore W3037536204C2778967481 @default.
- W3037536204 hasConceptScore W3037536204C2909208804 @default.
- W3037536204 hasConceptScore W3037536204C2909396630 @default.
- W3037536204 hasConceptScore W3037536204C505870484 @default.
- W3037536204 hasConceptScore W3037536204C86803240 @default.
- W3037536204 hasConceptScore W3037536204C8891405 @default.
- W3037536204 hasFunder F4320321001 @default.
- W3037536204 hasLocation W30375362041 @default.
- W3037536204 hasOpenAccess W3037536204 @default.
- W3037536204 hasPrimaryLocation W30375362041 @default.
- W3037536204 hasRelatedWork W1556307916 @default.
- W3037536204 hasRelatedWork W2048363111 @default.
- W3037536204 hasRelatedWork W2053276356 @default.
- W3037536204 hasRelatedWork W2088677474 @default.
- W3037536204 hasRelatedWork W2100872495 @default.
- W3037536204 hasRelatedWork W2103310157 @default.
- W3037536204 hasRelatedWork W2103515427 @default.
- W3037536204 hasRelatedWork W2141330728 @default.
- W3037536204 hasRelatedWork W3037536204 @default.
- W3037536204 hasRelatedWork W3114194756 @default.
- W3037536204 hasVolume "104" @default.
- W3037536204 isParatext "false" @default.
- W3037536204 isRetracted "false" @default.
- W3037536204 magId "3037536204" @default.
- W3037536204 workType "article" @default.