Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037591208> ?p ?o ?g. }
- W3037591208 endingPage "82" @default.
- W3037591208 startingPage "74" @default.
- W3037591208 abstract "Studies have shown that remote ischemic post-conditioning can improve brain damage caused by ischemia and hypoxia. However, the specific mechanism underlying this phenomenon is still unclear. The purpose of this study was to investigate the effects of remote ischemic post-conditioning on neuronal apoptosis and mitophagy after cardiopulmonary resuscitation (CPR) in rats.Male Sprague-Dawley rats were used to establish an asphyxia cardiac arrest model by clamping the tracheal duct. First, the expression levels of P53, Cytochrome c (Cytc), and Parkin in the cytoplasm and mitochondria were observed at 3, 6, 24, and 72 h after the restoration of spontaneous circulation (ROSC). Then neurological deficit scores, hippocampal neuron apoptosis, mitochondrial P53 and Parkin, cytoplasmic Cytc, and neuron ultrastructure were evaluated 24 h after ROSC.P53 and Parkin can translocate from the cytoplasm to the mitochondria, promoting the translocation of cytoplasmic Cytc to mitochondria after CPR, reaching a peak at 24 h after the ROSC. The P53 inhibitor Pifithrin-μ reduced apoptosis induced by P53 mitochondrial translocation. Apoptosis was induced after cardiac arrest and attenuated by remote ischemic postconditioning via inhibiting P53 mitochondrial translocation and the release of Cytc to the cytoplasm. In addition, remote ischemic postconditioning could inhibit Parkin-mediated mitophagy.Taken together, our results show that remote ischemic post-conditioning improves neural function after CPR by inhibiting P53 mitochondrial translocation-induced apoptosis and Parkin-mediated mitophagy." @default.
- W3037591208 created "2020-07-02" @default.
- W3037591208 creator A5023456387 @default.
- W3037591208 creator A5032301106 @default.
- W3037591208 creator A5039924898 @default.
- W3037591208 creator A5047327093 @default.
- W3037591208 creator A5071716377 @default.
- W3037591208 date "2020-06-23" @default.
- W3037591208 modified "2023-10-14" @default.
- W3037591208 title "Remote Ischemic Postconditioning Inhibits Hippocampal Neuronal Apoptosis and Mitophagy After Cardiopulmonary Resuscitation in Rats" @default.
- W3037591208 cites W1523367786 @default.
- W3037591208 cites W1753085297 @default.
- W3037591208 cites W1967245606 @default.
- W3037591208 cites W1981139339 @default.
- W3037591208 cites W1995278643 @default.
- W3037591208 cites W2006050950 @default.
- W3037591208 cites W2006578754 @default.
- W3037591208 cites W2008814812 @default.
- W3037591208 cites W2016013067 @default.
- W3037591208 cites W2020722847 @default.
- W3037591208 cites W2022257785 @default.
- W3037591208 cites W2023169605 @default.
- W3037591208 cites W2024701396 @default.
- W3037591208 cites W2031831043 @default.
- W3037591208 cites W2035101519 @default.
- W3037591208 cites W2040717895 @default.
- W3037591208 cites W2042515284 @default.
- W3037591208 cites W2050957972 @default.
- W3037591208 cites W2052144997 @default.
- W3037591208 cites W2054436439 @default.
- W3037591208 cites W2058056440 @default.
- W3037591208 cites W2060988288 @default.
- W3037591208 cites W2066218351 @default.
- W3037591208 cites W2093615780 @default.
- W3037591208 cites W2100983247 @default.
- W3037591208 cites W2110048031 @default.
- W3037591208 cites W2111718423 @default.
- W3037591208 cites W2162612159 @default.
- W3037591208 cites W2327005315 @default.
- W3037591208 cites W2329627651 @default.
- W3037591208 cites W2409565129 @default.
- W3037591208 cites W2509833592 @default.
- W3037591208 cites W2562228295 @default.
- W3037591208 cites W2605321388 @default.
- W3037591208 cites W2620423109 @default.
- W3037591208 cites W2735842356 @default.
- W3037591208 cites W2783486355 @default.
- W3037591208 cites W2783773694 @default.
- W3037591208 cites W2792601526 @default.
- W3037591208 cites W2801434815 @default.
- W3037591208 cites W2943131597 @default.
- W3037591208 cites W2978207279 @default.
- W3037591208 cites W4296816736 @default.
- W3037591208 doi "https://doi.org/10.1097/shk.0000000000001596" @default.
- W3037591208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32590695" @default.
- W3037591208 hasPublicationYear "2020" @default.
- W3037591208 type Work @default.
- W3037591208 sameAs 3037591208 @default.
- W3037591208 citedByCount "6" @default.
- W3037591208 countsByYear W30375912082021 @default.
- W3037591208 countsByYear W30375912082022 @default.
- W3037591208 countsByYear W30375912082023 @default.
- W3037591208 crossrefType "journal-article" @default.
- W3037591208 hasAuthorship W3037591208A5023456387 @default.
- W3037591208 hasAuthorship W3037591208A5032301106 @default.
- W3037591208 hasAuthorship W3037591208A5039924898 @default.
- W3037591208 hasAuthorship W3037591208A5047327093 @default.
- W3037591208 hasAuthorship W3037591208A5071716377 @default.
- W3037591208 hasBestOaLocation W30375912081 @default.
- W3037591208 hasConcept C126322002 @default.
- W3037591208 hasConcept C185592680 @default.
- W3037591208 hasConcept C190283241 @default.
- W3037591208 hasConcept C203522944 @default.
- W3037591208 hasConcept C2776804853 @default.
- W3037591208 hasConcept C2777668072 @default.
- W3037591208 hasConcept C2779134260 @default.
- W3037591208 hasConcept C2779324830 @default.
- W3037591208 hasConcept C2779734285 @default.
- W3037591208 hasConcept C28859421 @default.
- W3037591208 hasConcept C29311851 @default.
- W3037591208 hasConcept C42219234 @default.
- W3037591208 hasConcept C55493867 @default.
- W3037591208 hasConcept C71924100 @default.
- W3037591208 hasConcept C86803240 @default.
- W3037591208 hasConcept C95444343 @default.
- W3037591208 hasConcept C98274493 @default.
- W3037591208 hasConceptScore W3037591208C126322002 @default.
- W3037591208 hasConceptScore W3037591208C185592680 @default.
- W3037591208 hasConceptScore W3037591208C190283241 @default.
- W3037591208 hasConceptScore W3037591208C203522944 @default.
- W3037591208 hasConceptScore W3037591208C2776804853 @default.
- W3037591208 hasConceptScore W3037591208C2777668072 @default.
- W3037591208 hasConceptScore W3037591208C2779134260 @default.
- W3037591208 hasConceptScore W3037591208C2779324830 @default.
- W3037591208 hasConceptScore W3037591208C2779734285 @default.
- W3037591208 hasConceptScore W3037591208C28859421 @default.
- W3037591208 hasConceptScore W3037591208C29311851 @default.
- W3037591208 hasConceptScore W3037591208C42219234 @default.