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• W3037642079 startingPage "108084" @default.
• W3037642079 abstract "Abstract Three new spherical sulfated cellobiose–polylysine dendrimers of increasing generations bearing negatively charged sulfate groups were prepared by sulfating the corresponding cellobiose–polylysine dendrimers. The first, second, and third-generation derivatives exhibited potent anti-HIV activity with EC50 values of 3.7, 0.6, and 1.5 μg/mL, respectively, in constant to sulfated oligosaccharides with low anti-HIV activity, while the second-generation sulfated dendrimer was the most active. Surface plasmon resonance measurements with poly- l -lysine bearing positively charged amino acids as a model of the HIV surface glycoprotein gp120, indicated that the second-generation dendrimer had the lowest dissociation constant (KD = 1.86 × 10−12 M). Both the particle size and ζ potential increased in the presence of poly- l -lysine. It was proven that the moderate distance between the terminal sulfated cellobiose units in the second-generation dendrimer favored the high anti-HIV activity, owing to the electrostatic interactions developed due to the cluster effect." @default.
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• W3037642079 date "2020-09-01" @default.
• W3037642079 modified "2023-10-10" @default.
• W3037642079 title "Elucidation of anti-HIV mechanism of sulfated cellobiose–polylysine dendrimers" @default.
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• W3037642079 doi "https://doi.org/10.1016/j.carres.2020.108084" @default.
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