FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037674310> ?p ?o ?g. }

• W3037674310 endingPage "931" @default.
• W3037674310 startingPage "919" @default.
• W3037674310 abstract "Abstract Background Therapeutic cancer vaccines are an attractive approach for treating malignant tumours, and successful tumour eradication depends primarily on controlling tumour immunosuppression status as well as heterogeneity of tumour cells driven by epigenetic alterations. Methods Peptide-loaded dendritic cell (DC) prime and non-infectious peptide booster heterologous immunisations were assessed for the immunogenicity of polo-like kinase-1 (PLK1)-derived peptides. Heterologous vaccination regimen targeting multiple shared tumour antigens simultaneously with PD-L1 blockade was assessed against murine myeloid leukaemia. Results A synthetic PLK1 122 (DSDFVFVVL)-based heterologous vaccination generated large numbers of long-lasting antigen-specific CD8 T-cells eliciting therapeutic effects against various established tumours. The therapeutic efficacy of single antigen-targeting PLK1 122 -based vaccine with sufficient endurance of PD-L1 blockade toward C1498 leukaemia relied on the heterogeneous clonal levels of MHC-I and PD-L1 expression. A novel multi-peptide-based vaccination targeting PLK1 and survivin simultaneously along with PD1 blockade led to complete tumour eradication and long-term survival in mice with clonally heterologous C1498 myeloid leukaemia. Conclusions Our findings suggest that PLK1 could be an attractive immunotherapeutic target antigen for cancer immunotherapy, and that similar strategies would be applicable for the optimisation of cancer vaccines for the treatment of numerous viral diseases and malignant tumours." @default.
• W3037674310 created "2020-07-02" @default.
• W3037674310 creator A5004601067 @default.
• W3037674310 creator A5036954906 @default.
• W3037674310 creator A5055897061 @default.
• W3037674310 creator A5063810912 @default.
• W3037674310 creator A5076399260 @default.
• W3037674310 creator A5080908519 @default.
• W3037674310 date "2020-06-29" @default.
• W3037674310 modified "2023-10-08" @default.
• W3037674310 title "An effective peptide vaccine strategy circumventing clonal MHC heterogeneity of murine myeloid leukaemia" @default.
• W3037674310 cites W1480342889 @default.
• W3037674310 cites W1895814318 @default.
• W3037674310 cites W1965615377 @default.
• W3037674310 cites W1969117389 @default.
• W3037674310 cites W1978721974 @default.
• W3037674310 cites W1982488143 @default.
• W3037674310 cites W2010709305 @default.
• W3037674310 cites W2022538460 @default.
• W3037674310 cites W2033096493 @default.
• W3037674310 cites W2038702089 @default.
• W3037674310 cites W2039123767 @default.
• W3037674310 cites W2042662562 @default.
• W3037674310 cites W2048829888 @default.
• W3037674310 cites W2051938173 @default.
• W3037674310 cites W2057063239 @default.
• W3037674310 cites W2057653457 @default.
• W3037674310 cites W2071523891 @default.
• W3037674310 cites W2072022331 @default.
• W3037674310 cites W2087734794 @default.
• W3037674310 cites W2088951369 @default.
• W3037674310 cites W2093144236 @default.
• W3037674310 cites W2105400883 @default.
• W3037674310 cites W2110864471 @default.
• W3037674310 cites W2115721890 @default.
• W3037674310 cites W2129702476 @default.
• W3037674310 cites W2130011407 @default.
• W3037674310 cites W2150640296 @default.
• W3037674310 cites W2172170289 @default.
• W3037674310 cites W2199953088 @default.
• W3037674310 cites W2212433271 @default.
• W3037674310 cites W2232549736 @default.
• W3037674310 cites W2406806158 @default.
• W3037674310 cites W2410879014 @default.
• W3037674310 cites W2467902526 @default.
• W3037674310 cites W2469291698 @default.
• W3037674310 cites W2514418134 @default.
• W3037674310 cites W2586629973 @default.
• W3037674310 cites W2587048937 @default.
• W3037674310 cites W2728365508 @default.
• W3037674310 cites W2767931551 @default.
• W3037674310 cites W2782007611 @default.
• W3037674310 cites W2801309958 @default.
• W3037674310 cites W2806895459 @default.
• W3037674310 cites W2890854864 @default.
• W3037674310 cites W2913400417 @default.
• W3037674310 cites W4230074479 @default.
• W3037674310 cites W4243848630 @default.
• W3037674310 cites W4254055122 @default.
• W3037674310 doi "https://doi.org/10.1038/s41416-020-0955-y" @default.
• W3037674310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7492404" @default.
• W3037674310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32595211" @default.
• W3037674310 hasPublicationYear "2020" @default.
• W3037674310 type Work @default.
• W3037674310 sameAs 3037674310 @default.
• W3037674310 citedByCount "0" @default.
• W3037674310 crossrefType "journal-article" @default.
• W3037674310 hasAuthorship W3037674310A5004601067 @default.
• W3037674310 hasAuthorship W3037674310A5036954906 @default.
• W3037674310 hasAuthorship W3037674310A5055897061 @default.
• W3037674310 hasAuthorship W3037674310A5063810912 @default.
• W3037674310 hasAuthorship W3037674310A5076399260 @default.
• W3037674310 hasAuthorship W3037674310A5080908519 @default.
• W3037674310 hasBestOaLocation W30376743101 @default.
• W3037674310 hasConcept C104317684 @default.
• W3037674310 hasConcept C147483822 @default.
• W3037674310 hasConcept C159047783 @default.
• W3037674310 hasConcept C195616568 @default.
• W3037674310 hasConcept C203014093 @default.
• W3037674310 hasConcept C22070199 @default.
• W3037674310 hasConcept C2776789287 @default.
• W3037674310 hasConcept C2777701055 @default.
• W3037674310 hasConcept C2778378633 @default.
• W3037674310 hasConcept C2779282312 @default.
• W3037674310 hasConcept C2780115692 @default.
• W3037674310 hasConcept C2780674031 @default.
• W3037674310 hasConcept C502942594 @default.
• W3037674310 hasConcept C55493867 @default.
• W3037674310 hasConcept C86803240 @default.
• W3037674310 hasConcept C8891405 @default.
• W3037674310 hasConceptScore W3037674310C104317684 @default.
• W3037674310 hasConceptScore W3037674310C147483822 @default.
• W3037674310 hasConceptScore W3037674310C159047783 @default.
• W3037674310 hasConceptScore W3037674310C195616568 @default.
• W3037674310 hasConceptScore W3037674310C203014093 @default.
• W3037674310 hasConceptScore W3037674310C22070199 @default.
• W3037674310 hasConceptScore W3037674310C2776789287 @default.
• W3037674310 hasConceptScore W3037674310C2777701055 @default.

• next