Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037702972> ?p ?o ?g. }
- W3037702972 endingPage "1952" @default.
- W3037702972 startingPage "1934" @default.
- W3037702972 abstract "Spreading depolarization (SD) is a self-propagated wave that provokes transient disorder of numerous cell and tissue functions, and that may kill neurons in metabolically compromised tissue. We examined the mechanisms underlying the main hallmark of SD, a giant extracellular potential (ΔV o ) for which multiple electromotive forces have been proposed. The end-point is that neurons and not glia, dendritic channels and not spatial currents, and increased sodium conductance rather than potassium gradients, appear to be the main actors in the generation of the negative ΔV o . Neuronal currents are established by two mechanisms, a voltage independent dendritic current, and the differential polarization along the neuron membranes. Notably, despite of a marked drop of ion gradients, these evolve significantly during SD, and yet the membrane potential remains clamped at zero no matter how much inward current is present. There may be substantial inward current or none in function of the evolving portion of the neuron dendrites with SD-activated channels. We propose that the ΔV o promotes swelling-induced dendritic damage. Understanding SD electrogenesis requires all elements relevant for membrane potential, action currents, field potentials and volume conduction to be jointly considered, and it has already encouraged the search for new targets to limit SD-related pathology." @default.
- W3037702972 created "2020-07-02" @default.
- W3037702972 creator A5009000104 @default.
- W3037702972 creator A5035811913 @default.
- W3037702972 date "2020-06-24" @default.
- W3037702972 modified "2023-10-02" @default.
- W3037702972 title "Mechanisms of the negative potential associated with Leão’s spreading depolarization: A history of brain electrogenesis" @default.
- W3037702972 cites W1243663029 @default.
- W3037702972 cites W1579712037 @default.
- W3037702972 cites W1801274690 @default.
- W3037702972 cites W1820068830 @default.
- W3037702972 cites W1838245412 @default.
- W3037702972 cites W1864765563 @default.
- W3037702972 cites W1903397794 @default.
- W3037702972 cites W1921430386 @default.
- W3037702972 cites W1959780907 @default.
- W3037702972 cites W1971854717 @default.
- W3037702972 cites W1972795959 @default.
- W3037702972 cites W1973541292 @default.
- W3037702972 cites W1975893829 @default.
- W3037702972 cites W1977873342 @default.
- W3037702972 cites W1978329654 @default.
- W3037702972 cites W1979009614 @default.
- W3037702972 cites W1979778632 @default.
- W3037702972 cites W1981334890 @default.
- W3037702972 cites W1985940938 @default.
- W3037702972 cites W1988234338 @default.
- W3037702972 cites W1989714047 @default.
- W3037702972 cites W1994416969 @default.
- W3037702972 cites W1994907910 @default.
- W3037702972 cites W1997521952 @default.
- W3037702972 cites W1998763985 @default.
- W3037702972 cites W2003509571 @default.
- W3037702972 cites W2003620217 @default.
- W3037702972 cites W2008978687 @default.
- W3037702972 cites W2011909109 @default.
- W3037702972 cites W2012968975 @default.
- W3037702972 cites W2013752437 @default.
- W3037702972 cites W2024400996 @default.
- W3037702972 cites W2025413464 @default.
- W3037702972 cites W2025537889 @default.
- W3037702972 cites W2026247688 @default.
- W3037702972 cites W2034441569 @default.
- W3037702972 cites W2034844739 @default.
- W3037702972 cites W2035334102 @default.
- W3037702972 cites W2044636914 @default.
- W3037702972 cites W2044730840 @default.
- W3037702972 cites W2045240090 @default.
- W3037702972 cites W2045603017 @default.
- W3037702972 cites W2055077284 @default.
- W3037702972 cites W2056111826 @default.
- W3037702972 cites W2057632590 @default.
- W3037702972 cites W2057651318 @default.
- W3037702972 cites W2057852187 @default.
- W3037702972 cites W2060215608 @default.
- W3037702972 cites W2061510643 @default.
- W3037702972 cites W2062924373 @default.
- W3037702972 cites W2063434151 @default.
- W3037702972 cites W2063919105 @default.
- W3037702972 cites W2064783444 @default.
- W3037702972 cites W2066774202 @default.
- W3037702972 cites W2068890533 @default.
- W3037702972 cites W2072870888 @default.
- W3037702972 cites W2073402789 @default.
- W3037702972 cites W2075166773 @default.
- W3037702972 cites W2079680122 @default.
- W3037702972 cites W2080020902 @default.
- W3037702972 cites W2080024191 @default.
- W3037702972 cites W2089428334 @default.
- W3037702972 cites W2090971379 @default.
- W3037702972 cites W2093693338 @default.
- W3037702972 cites W2097072341 @default.
- W3037702972 cites W2102087494 @default.
- W3037702972 cites W2103816576 @default.
- W3037702972 cites W2104592058 @default.
- W3037702972 cites W2105056821 @default.
- W3037702972 cites W2106235427 @default.
- W3037702972 cites W2110615319 @default.
- W3037702972 cites W2115237675 @default.
- W3037702972 cites W2115817328 @default.
- W3037702972 cites W2120838215 @default.
- W3037702972 cites W2126568243 @default.
- W3037702972 cites W2131054267 @default.
- W3037702972 cites W2135387205 @default.
- W3037702972 cites W2135877388 @default.
- W3037702972 cites W2141827300 @default.
- W3037702972 cites W2144759791 @default.
- W3037702972 cites W2151777259 @default.
- W3037702972 cites W2153662862 @default.
- W3037702972 cites W2157527374 @default.
- W3037702972 cites W2158116085 @default.
- W3037702972 cites W2169123068 @default.
- W3037702972 cites W2170373191 @default.
- W3037702972 cites W2171186011 @default.
- W3037702972 cites W2179369946 @default.
- W3037702972 cites W2217637761 @default.
- W3037702972 cites W2220342468 @default.
- W3037702972 cites W2241303199 @default.