Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037730446> ?p ?o ?g. }
- W3037730446 endingPage "3590" @default.
- W3037730446 startingPage "3586" @default.
- W3037730446 abstract "Abstract Albomycin δ 2 is a sulfur‐containing sideromycin natural product that shows potent antibacterial activity against clinically important pathogens. The l ‐serine‐thioheptose dipeptide partial structure, known as SB‐217452, has been found to be the active seryl‐tRNA synthetase inhibitor component of albomycin δ 2 . Herein, it is demonstrated that AbmF catalyzes condensation between the 6′‐amino‐4′‐thionucleoside with the d ‐ ribo configuration and seryl‐adenylate supplied by the serine adenylation activity of AbmK. Formation of the dipeptide is followed by C3′‐epimerization to produce SB‐217452 with the d ‐ xylo configuration, which is catalyzed by the radical S ‐adenosyl‐ l ‐methionine enzyme AbmJ. Gene deletion suggests that AbmC is involved in peptide assembly linking SB‐217452 with the siderophore moiety. This study establishes how the albomycin biosynthetic machinery generates its antimicrobial component SB‐217452." @default.
- W3037730446 created "2020-07-02" @default.
- W3037730446 creator A5046030965 @default.
- W3037730446 creator A5057008445 @default.
- W3037730446 creator A5067380844 @default.
- W3037730446 creator A5084628633 @default.
- W3037730446 creator A5084634014 @default.
- W3037730446 date "2020-01-29" @default.
- W3037730446 modified "2023-09-27" @default.
- W3037730446 title "Identification of the Enzymes Mediating the Maturation of the Seryl‐tRNA Synthetase Inhibitor SB‐217452 during the Biosynthesis of Albomycins" @default.
- W3037730446 cites W1538196126 @default.
- W3037730446 cites W1973381547 @default.
- W3037730446 cites W1979577469 @default.
- W3037730446 cites W1982793579 @default.
- W3037730446 cites W1984956671 @default.
- W3037730446 cites W1994711890 @default.
- W3037730446 cites W2006469447 @default.
- W3037730446 cites W2011625264 @default.
- W3037730446 cites W2015165072 @default.
- W3037730446 cites W2021494226 @default.
- W3037730446 cites W2030143932 @default.
- W3037730446 cites W2037312364 @default.
- W3037730446 cites W2048214940 @default.
- W3037730446 cites W2066415386 @default.
- W3037730446 cites W2082667898 @default.
- W3037730446 cites W2084599684 @default.
- W3037730446 cites W2094335398 @default.
- W3037730446 cites W2100918802 @default.
- W3037730446 cites W2101514742 @default.
- W3037730446 cites W2124877782 @default.
- W3037730446 cites W2149076892 @default.
- W3037730446 cites W2150710339 @default.
- W3037730446 cites W2152016304 @default.
- W3037730446 cites W2159967424 @default.
- W3037730446 cites W2335442043 @default.
- W3037730446 cites W2396643508 @default.
- W3037730446 cites W2461287631 @default.
- W3037730446 cites W2562030812 @default.
- W3037730446 cites W2569920290 @default.
- W3037730446 cites W2586914328 @default.
- W3037730446 cites W2600438420 @default.
- W3037730446 cites W2602946330 @default.
- W3037730446 cites W2777114057 @default.
- W3037730446 cites W2794083769 @default.
- W3037730446 cites W2885958637 @default.
- W3037730446 cites W2888719352 @default.
- W3037730446 cites W2908831754 @default.
- W3037730446 cites W2913695311 @default.
- W3037730446 cites W4233713719 @default.
- W3037730446 doi "https://doi.org/10.1002/ange.201915275" @default.
- W3037730446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31863717" @default.
- W3037730446 hasPublicationYear "2020" @default.
- W3037730446 type Work @default.
- W3037730446 sameAs 3037730446 @default.
- W3037730446 citedByCount "5" @default.
- W3037730446 countsByYear W30377304462021 @default.
- W3037730446 countsByYear W30377304462022 @default.
- W3037730446 crossrefType "journal-article" @default.
- W3037730446 hasAuthorship W3037730446A5046030965 @default.
- W3037730446 hasAuthorship W3037730446A5057008445 @default.
- W3037730446 hasAuthorship W3037730446A5067380844 @default.
- W3037730446 hasAuthorship W3037730446A5084628633 @default.
- W3037730446 hasAuthorship W3037730446A5084634014 @default.
- W3037730446 hasConcept C160403918 @default.
- W3037730446 hasConcept C181199279 @default.
- W3037730446 hasConcept C185592680 @default.
- W3037730446 hasConcept C2776414213 @default.
- W3037730446 hasConcept C2776568683 @default.
- W3037730446 hasConcept C2777379556 @default.
- W3037730446 hasConcept C2779138802 @default.
- W3037730446 hasConcept C2781374117 @default.
- W3037730446 hasConcept C515207424 @default.
- W3037730446 hasConcept C553450214 @default.
- W3037730446 hasConcept C55493867 @default.
- W3037730446 hasConcept C71240020 @default.
- W3037730446 hasConceptScore W3037730446C160403918 @default.
- W3037730446 hasConceptScore W3037730446C181199279 @default.
- W3037730446 hasConceptScore W3037730446C185592680 @default.
- W3037730446 hasConceptScore W3037730446C2776414213 @default.
- W3037730446 hasConceptScore W3037730446C2776568683 @default.
- W3037730446 hasConceptScore W3037730446C2777379556 @default.
- W3037730446 hasConceptScore W3037730446C2779138802 @default.
- W3037730446 hasConceptScore W3037730446C2781374117 @default.
- W3037730446 hasConceptScore W3037730446C515207424 @default.
- W3037730446 hasConceptScore W3037730446C553450214 @default.
- W3037730446 hasConceptScore W3037730446C55493867 @default.
- W3037730446 hasConceptScore W3037730446C71240020 @default.
- W3037730446 hasFunder F4320332161 @default.
- W3037730446 hasIssue "9" @default.
- W3037730446 hasLocation W30377304461 @default.
- W3037730446 hasOpenAccess W3037730446 @default.
- W3037730446 hasPrimaryLocation W30377304461 @default.
- W3037730446 hasRelatedWork W117670170 @default.
- W3037730446 hasRelatedWork W1844402532 @default.
- W3037730446 hasRelatedWork W1989099340 @default.
- W3037730446 hasRelatedWork W1990812439 @default.
- W3037730446 hasRelatedWork W2027306779 @default.
- W3037730446 hasRelatedWork W2074402828 @default.