Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037735009> ?p ?o ?g. }
- W3037735009 endingPage "1941" @default.
- W3037735009 startingPage "1941" @default.
- W3037735009 abstract "Glial cells are fundamental players in the central nervous system (CNS) development and homeostasis, both in health and disease states. In Parkinson’s disease (PD), a dysfunctional glia-neuron crosstalk represents a common final pathway contributing to the chronic and progressive death of dopaminergic (DAergic) neurons of the substantia nigra pars compacta (SNpc). Notably, glial cells communicating with each other by an array of molecules, can acquire a “beneficial” or “destructive” phenotype, thereby enhancing neuronal death/vulnerability and/or exerting critical neuroprotective and neuroreparative functions, with mechanisms that are actively investigated. An important way of delivering messenger molecules within this glia-neuron cross-talk consists in the secretion of extracellular vesicles (EVs). EVs are nano-sized membranous particles able to convey a wide range of molecular cargoes in a controlled way, depending on the specific donor cell and the microenvironmental milieu. Given the dual role of glia in PD, glia-derived EVs may deliver molecules carrying various messages for the vulnerable/dysfunctional DAergic neurons. Here, we summarize the state-of-the-art of glial-neuron interactions and glia-derived EVs in PD. Also, EVs have the ability to cross the blood brain barrier (BBB), thus acting both within the CNS and outside, in the periphery. In these regards, this review discloses the emerging applications of EVs, with a special focus on glia-derived EVs as potential carriers of new biomarkers and nanotherapeutics for PD." @default.
- W3037735009 created "2020-07-02" @default.
- W3037735009 creator A5002152789 @default.
- W3037735009 creator A5020938978 @default.
- W3037735009 creator A5021181399 @default.
- W3037735009 creator A5031496401 @default.
- W3037735009 creator A5053359938 @default.
- W3037735009 creator A5056117262 @default.
- W3037735009 creator A5060842798 @default.
- W3037735009 creator A5074264245 @default.
- W3037735009 creator A5075407827 @default.
- W3037735009 creator A5090894389 @default.
- W3037735009 date "2020-06-21" @default.
- W3037735009 modified "2023-10-06" @default.
- W3037735009 title "Glia-Derived Extracellular Vesicles in Parkinson’s Disease" @default.
- W3037735009 cites W12352589 @default.
- W3037735009 cites W1421415727 @default.
- W3037735009 cites W1518549841 @default.
- W3037735009 cites W1524589668 @default.
- W3037735009 cites W1556003326 @default.
- W3037735009 cites W1580441010 @default.
- W3037735009 cites W1592283056 @default.
- W3037735009 cites W1721689174 @default.
- W3037735009 cites W1751448311 @default.
- W3037735009 cites W1765527890 @default.
- W3037735009 cites W1777606123 @default.
- W3037735009 cites W1835553180 @default.
- W3037735009 cites W1858755391 @default.
- W3037735009 cites W1889609763 @default.
- W3037735009 cites W1956428707 @default.
- W3037735009 cites W1964810666 @default.
- W3037735009 cites W1965976131 @default.
- W3037735009 cites W1966987564 @default.
- W3037735009 cites W1969800514 @default.
- W3037735009 cites W1971599063 @default.
- W3037735009 cites W1972423412 @default.
- W3037735009 cites W1972754078 @default.
- W3037735009 cites W1974924674 @default.
- W3037735009 cites W1975774284 @default.
- W3037735009 cites W1976325983 @default.
- W3037735009 cites W1976769213 @default.
- W3037735009 cites W1982910460 @default.
- W3037735009 cites W1988521942 @default.
- W3037735009 cites W1989279492 @default.
- W3037735009 cites W1990000696 @default.
- W3037735009 cites W1991948315 @default.
- W3037735009 cites W1992911806 @default.
- W3037735009 cites W1994215544 @default.
- W3037735009 cites W1996197263 @default.
- W3037735009 cites W1997195117 @default.
- W3037735009 cites W2005379429 @default.
- W3037735009 cites W2006878746 @default.
- W3037735009 cites W2007148556 @default.
- W3037735009 cites W2008170515 @default.
- W3037735009 cites W2010414623 @default.
- W3037735009 cites W2010578119 @default.
- W3037735009 cites W2012088452 @default.
- W3037735009 cites W2014413787 @default.
- W3037735009 cites W2014463750 @default.
- W3037735009 cites W2015283405 @default.
- W3037735009 cites W2015555425 @default.
- W3037735009 cites W2016927879 @default.
- W3037735009 cites W2017364016 @default.
- W3037735009 cites W2025323869 @default.
- W3037735009 cites W2028972354 @default.
- W3037735009 cites W2036600670 @default.
- W3037735009 cites W2037891639 @default.
- W3037735009 cites W2039789186 @default.
- W3037735009 cites W2040415612 @default.
- W3037735009 cites W2041046421 @default.
- W3037735009 cites W2041831342 @default.
- W3037735009 cites W2041966991 @default.
- W3037735009 cites W2043676089 @default.
- W3037735009 cites W2047585900 @default.
- W3037735009 cites W2048193235 @default.
- W3037735009 cites W2048526645 @default.
- W3037735009 cites W2053051103 @default.
- W3037735009 cites W2054810445 @default.
- W3037735009 cites W2056094172 @default.
- W3037735009 cites W2058594344 @default.
- W3037735009 cites W2061888284 @default.
- W3037735009 cites W2065236536 @default.
- W3037735009 cites W2068312274 @default.
- W3037735009 cites W2074661552 @default.
- W3037735009 cites W2075680729 @default.
- W3037735009 cites W2075685652 @default.
- W3037735009 cites W2079830794 @default.
- W3037735009 cites W2082510957 @default.
- W3037735009 cites W2082513593 @default.
- W3037735009 cites W2083115355 @default.
- W3037735009 cites W2084307273 @default.
- W3037735009 cites W2086612059 @default.
- W3037735009 cites W2087394121 @default.
- W3037735009 cites W2087482196 @default.
- W3037735009 cites W2089204174 @default.
- W3037735009 cites W2089900719 @default.
- W3037735009 cites W2090044366 @default.
- W3037735009 cites W2094660330 @default.