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- W3037782886 endingPage "4248" @default.
- W3037782886 startingPage "4248" @default.
- W3037782886 abstract "Structure-based and computer-aided drug design approaches are commonly considered to have been successful in the fields of cancer and antiviral drug discovery but not as much for antibacterial drug development. The search for novel anti-tuberculosis agents is indeed an emblematic example of this trend. Although huge efforts, by consortiums and groups worldwide, dramatically increased the structural coverage of the Mycobacterium tuberculosis proteome, the vast majority of candidate drugs included in clinical trials during the last decade were issued from phenotypic screenings on whole mycobacterial cells. We developed here three selected case studies, i.e., the serine/threonine (Ser/Thr) kinases—protein kinase (Pkn) B and PknG, considered as very promising targets for a long time, and the DNA gyrase of M. tuberculosis, a well-known, pharmacologically validated target. We illustrated some of the challenges that rational, target-based drug discovery programs in tuberculosis (TB) still have to face, and, finally, discussed the perspectives opened by the recent, methodological developments in structural biology and integrative techniques." @default.
- W3037782886 created "2020-07-02" @default.
- W3037782886 creator A5065755441 @default.
- W3037782886 creator A5079041262 @default.
- W3037782886 creator A5084388900 @default.
- W3037782886 date "2020-06-20" @default.
- W3037782886 modified "2023-10-18" @default.
- W3037782886 title "Structure-Based Drug Design for Tuberculosis: Challenges Still Ahead" @default.
- W3037782886 cites W1490764204 @default.
- W3037782886 cites W1527983242 @default.
- W3037782886 cites W1899621860 @default.
- W3037782886 cites W1964141703 @default.
- W3037782886 cites W1972893231 @default.
- W3037782886 cites W1976425432 @default.
- W3037782886 cites W1976644499 @default.
- W3037782886 cites W1978251954 @default.
- W3037782886 cites W1979474715 @default.
- W3037782886 cites W1979700870 @default.
- W3037782886 cites W1983215103 @default.
- W3037782886 cites W1984096283 @default.
- W3037782886 cites W1986106712 @default.
- W3037782886 cites W1990351781 @default.
- W3037782886 cites W1992761237 @default.
- W3037782886 cites W1993817085 @default.
- W3037782886 cites W1996038152 @default.
- W3037782886 cites W1997882784 @default.
- W3037782886 cites W2006433340 @default.
- W3037782886 cites W2012868449 @default.
- W3037782886 cites W2014575289 @default.
- W3037782886 cites W2016021369 @default.
- W3037782886 cites W2016520940 @default.
- W3037782886 cites W2020983758 @default.
- W3037782886 cites W2039403245 @default.
- W3037782886 cites W2046639437 @default.
- W3037782886 cites W2051925784 @default.
- W3037782886 cites W2057498265 @default.
- W3037782886 cites W2058558815 @default.
- W3037782886 cites W2058693910 @default.
- W3037782886 cites W2059907843 @default.
- W3037782886 cites W2062173234 @default.
- W3037782886 cites W2069870006 @default.
- W3037782886 cites W2071123953 @default.
- W3037782886 cites W2071325808 @default.
- W3037782886 cites W2072256609 @default.
- W3037782886 cites W2072399351 @default.
- W3037782886 cites W2072737923 @default.
- W3037782886 cites W2073746700 @default.
- W3037782886 cites W2074557538 @default.
- W3037782886 cites W2075929473 @default.
- W3037782886 cites W2078355424 @default.
- W3037782886 cites W2081220000 @default.
- W3037782886 cites W2086987219 @default.
- W3037782886 cites W2087985297 @default.
- W3037782886 cites W2091586024 @default.
- W3037782886 cites W2095438923 @default.
- W3037782886 cites W2098530568 @default.
- W3037782886 cites W2104219710 @default.
- W3037782886 cites W2113201746 @default.
- W3037782886 cites W2115895428 @default.
- W3037782886 cites W2119838034 @default.
- W3037782886 cites W2124525553 @default.
- W3037782886 cites W2128482141 @default.
- W3037782886 cites W2129802766 @default.
- W3037782886 cites W2133942178 @default.
- W3037782886 cites W2138778824 @default.
- W3037782886 cites W2140763734 @default.
- W3037782886 cites W2146778078 @default.
- W3037782886 cites W2147049072 @default.
- W3037782886 cites W2158023121 @default.
- W3037782886 cites W2160483498 @default.
- W3037782886 cites W2283132526 @default.
- W3037782886 cites W2322576963 @default.
- W3037782886 cites W2324967976 @default.
- W3037782886 cites W2498876603 @default.
- W3037782886 cites W2530454222 @default.
- W3037782886 cites W2555539905 @default.
- W3037782886 cites W2570384863 @default.
- W3037782886 cites W2579264422 @default.
- W3037782886 cites W2614867515 @default.
- W3037782886 cites W2729669076 @default.
- W3037782886 cites W2746484255 @default.
- W3037782886 cites W2763160323 @default.
- W3037782886 cites W2770916735 @default.
- W3037782886 cites W2794310103 @default.
- W3037782886 cites W2800885808 @default.
- W3037782886 cites W2801082928 @default.
- W3037782886 cites W2802939794 @default.
- W3037782886 cites W2805746983 @default.
- W3037782886 cites W2809160530 @default.
- W3037782886 cites W2810748772 @default.
- W3037782886 cites W2884433182 @default.
- W3037782886 cites W2886377872 @default.
- W3037782886 cites W2892083369 @default.
- W3037782886 cites W2895517266 @default.
- W3037782886 cites W2901719664 @default.
- W3037782886 cites W2902979941 @default.
- W3037782886 cites W2906097593 @default.
- W3037782886 cites W2909180420 @default.