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- W3037818500 abstract "Objective: To determine predictors of cognitive impairment in essential hypertensive patients after 10-years of follow-up. Design and method: In 118 hypertensive patients (average age 66.8 ± 0.8, 69 males, mean hypertension history at the baseline 10.0 ± .4 years) we measured office blood pressure, ultrasonographically diameter (D) of common carotid (CCA) artery, carotid intima-media thickness (IMT), performed Mini Mental State Examination (MMSE), ambulatory blood pressure monitoring twice: initially and after a mean period of 10 years. Also morning fasting venous blood samples were obtained from all subjects for uric acid, lipid profile, glucose assays. Age and other cardiovascular risk factors were included in the analysis. Results: There was a significant deterioration in the MMSE results during the follow-up: 28.9 ± 0.1 at the baseline vs 27.4 ± 0.2 after 10 years, p = 0,001. The cognitive decline was significantly associated with initial and repeated measurement of IMT (accordingly: b = -0.221, p = 0.001 and b = -0.100, p = 0.001). This association was independent of age, body mass index and hypertension history. No statistically significant associations were obtained between the MMSE results and systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides, LDL cholesterol, serum uric acid, glucose. Conclusions: Our data suggested that cognitive impairment in essential hypertensive patients associated with severity of the carotid structure damage and carotid intima-media thickness at the baseline and after 10 years were independent predictors of cognitive decline in these patients." @default.
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- W3037818500 date "2015-06-01" @default.
- W3037818500 modified "2023-09-26" @default.
- W3037818500 title "PP.34.22" @default.
- W3037818500 doi "https://doi.org/10.1097/01.hjh.0000468776.51106.72" @default.
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