FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037825825> ?p ?o ?g. }

• W3037825825 endingPage "202" @default.
• W3037825825 startingPage "181" @default.
• W3037825825 abstract "Significant advances have been made toward discovering allosteric inhibitors for challenging drug targets such as the Ras family of membrane-associated signaling proteins. Malfunction of Ras proteins due to somatic mutations is associated with up to a quarter of all human cancers. Computational techniques have played critical roles in identifying and characterizing allosteric ligand-binding sites on these proteins, and to screen ligand libraries against those sites. These efforts, combined with a wide range of biophysical, structural, biochemical and cell biological experiments, are beginning to yield promising inhibitors to treat malignancies associated with mutated Ras proteins. In this chapter, we discuss some of these developments and how the lessons learned from Ras might be applied to similar other challenging drug targets." @default.
• W3037825825 created "2020-07-02" @default.
• W3037825825 creator A5033192681 @default.
• W3037825825 creator A5087588530 @default.
• W3037825825 date "2020-01-01" @default.
• W3037825825 modified "2023-10-04" @default.
• W3037825825 title "How to make an undruggable enzyme druggable: lessons from ras proteins" @default.
• W3037825825 cites W1530374442 @default.
• W3037825825 cites W1572208904 @default.
• W3037825825 cites W1608710587 @default.
• W3037825825 cites W1852817901 @default.
• W3037825825 cites W1896328454 @default.
• W3037825825 cites W1960357661 @default.
• W3037825825 cites W1966558949 @default.
• W3037825825 cites W1969542329 @default.
• W3037825825 cites W1970856032 @default.
• W3037825825 cites W1971102429 @default.
• W3037825825 cites W1971103887 @default.
• W3037825825 cites W1971843650 @default.
• W3037825825 cites W1973734799 @default.
• W3037825825 cites W1973907387 @default.
• W3037825825 cites W1985981634 @default.
• W3037825825 cites W1986358267 @default.
• W3037825825 cites W1986434830 @default.
• W3037825825 cites W1996563138 @default.
• W3037825825 cites W2001710734 @default.
• W3037825825 cites W2004792969 @default.
• W3037825825 cites W2007327754 @default.
• W3037825825 cites W2012479646 @default.
• W3037825825 cites W2012982780 @default.
• W3037825825 cites W2014017623 @default.
• W3037825825 cites W2018535049 @default.
• W3037825825 cites W2022920832 @default.
• W3037825825 cites W2023238175 @default.
• W3037825825 cites W2024712545 @default.
• W3037825825 cites W2024839004 @default.
• W3037825825 cites W2027357567 @default.
• W3037825825 cites W2029446677 @default.
• W3037825825 cites W2029672666 @default.
• W3037825825 cites W2033918131 @default.
• W3037825825 cites W2035049668 @default.
• W3037825825 cites W2042316019 @default.
• W3037825825 cites W2046845314 @default.
• W3037825825 cites W2047509756 @default.
• W3037825825 cites W2056199226 @default.
• W3037825825 cites W2060471176 @default.
• W3037825825 cites W2062919736 @default.
• W3037825825 cites W2071018921 @default.
• W3037825825 cites W2071697240 @default.
• W3037825825 cites W2073081213 @default.
• W3037825825 cites W2080534618 @default.
• W3037825825 cites W2081990599 @default.
• W3037825825 cites W2086880092 @default.
• W3037825825 cites W2092973995 @default.
• W3037825825 cites W2094022774 @default.
• W3037825825 cites W2098806204 @default.
• W3037825825 cites W2105902442 @default.
• W3037825825 cites W2108439464 @default.
• W3037825825 cites W2111017461 @default.
• W3037825825 cites W2112877031 @default.
• W3037825825 cites W2116332105 @default.
• W3037825825 cites W2121393047 @default.
• W3037825825 cites W2121951430 @default.
• W3037825825 cites W2122727567 @default.
• W3037825825 cites W2128339707 @default.
• W3037825825 cites W2128789136 @default.
• W3037825825 cites W2129551670 @default.
• W3037825825 cites W2129662453 @default.
• W3037825825 cites W2130182381 @default.
• W3037825825 cites W2135184154 @default.
• W3037825825 cites W2135371328 @default.
• W3037825825 cites W2138498601 @default.
• W3037825825 cites W2141965353 @default.
• W3037825825 cites W2142454421 @default.
• W3037825825 cites W2144811248 @default.
• W3037825825 cites W2146159891 @default.
• W3037825825 cites W2146926552 @default.
• W3037825825 cites W2150551377 @default.
• W3037825825 cites W2152230622 @default.
• W3037825825 cites W2154164444 @default.
• W3037825825 cites W2156194501 @default.
• W3037825825 cites W2158219305 @default.
• W3037825825 cites W2163188200 @default.
• W3037825825 cites W2164426030 @default.
• W3037825825 cites W2168833646 @default.
• W3037825825 cites W2200017991 @default.
• W3037825825 cites W2211839632 @default.
• W3037825825 cites W2293034743 @default.
• W3037825825 cites W2343614482 @default.
• W3037825825 cites W2363054795 @default.
• W3037825825 cites W2483704935 @default.
• W3037825825 cites W2548573003 @default.
• W3037825825 cites W2549286116 @default.
• W3037825825 cites W2571240151 @default.
• W3037825825 cites W2580339463 @default.
• W3037825825 cites W2589235955 @default.
• W3037825825 cites W2593877008 @default.
• W3037825825 cites W2593944954 @default.

• next