FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037835402> ?p ?o ?g. }

• W3037835402 endingPage "5392" @default.
• W3037835402 startingPage "5375" @default.
• W3037835402 abstract "Atherosclerosis, resulting from lipid dysregulation and vascular inflammation, causes atherosclerotic cardiovascular disease (ASCVD), which contributes to morbidity and mortality worldwide. Chalcone and its derivatives possess beneficial properties, including anti-inflammatory, antioxidant and antitumour activity with unknown cardioprotective effects. We aimed to develop an effective chalcone derivative with antiatherogenic potential.Human THP-1 cells and HUVECs were used as in vitro models. Western blots and real-time PCRs were performed to quantify protein, mRNA and miRNA expressions. The cholesterol efflux capacity was assayed by 3 H labelling of cholesterol. LDL receptor knockout (Ldlr-/- ) mice fed a high-fat diet were used as an in vivo atherogenesis model. Haematoxylin and eosin and oil red O staining were used to analyse plaque formation.Using ATP-binding cassette transporter A1 (ABCA1) expression we identified the chalcone derivative, 1m-6, which enhances ABCA1 expression and promotes cholesterol efflux in THP-1 macrophages. Moreover, 1m-6 stabilizes ABCA1 mRNA and suppresses the expression of potential ABCA1-regulating miRNAs through nuclear factor erythroid 2-related factor 2 (Nrf2)/haem oxygenase-1 (HO-1) signalling. Additionally, 1m-6 significantly inhibits TNF-α-induced expression of adhesion molecules, vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1), plus production of proinflammatory cytokines via inhibition of JAK/STAT3 activation and the modulation of Nrf2/HO-1 signalling in HUVECs. In atherosclerosis-prone mice, 1m-6 significantly reduces lipid accumulation and atherosclerotic plaque formation.Our study demonstrates that 1m-6 produces promising atheroprotective effects by enhancing cholesterol efflux and suppressing inflammation-induced endothelial dysfunction, which opens a new avenue for treating ASCVD.This article is part of a themed issue on Risk factors, comorbidities, and comedications in cardioprotection. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.23/issuetoc." @default.
• W3037835402 created "2020-07-02" @default.
• W3037835402 creator A5026685209 @default.
• W3037835402 creator A5035304411 @default.
• W3037835402 creator A5041348573 @default.
• W3037835402 creator A5065442504 @default.
• W3037835402 creator A5067582597 @default.
• W3037835402 creator A5067588058 @default.
• W3037835402 creator A5073923353 @default.
• W3037835402 creator A5077935418 @default.
• W3037835402 creator A5080380147 @default.
• W3037835402 creator A5082912293 @default.
• W3037835402 creator A5084822592 @default.
• W3037835402 creator A5085110349 @default.
• W3037835402 creator A5088508309 @default.
• W3037835402 date "2020-07-20" @default.
• W3037835402 modified "2023-10-15" @default.
• W3037835402 title "A chalcone derivative, 1m‐6, exhibits atheroprotective effects by increasing cholesterol efflux and reducing inflammation‐induced endothelial dysfunction" @default.
• W3037835402 cites W1508323668 @default.
• W3037835402 cites W1785455093 @default.
• W3037835402 cites W1905715704 @default.
• W3037835402 cites W1973149093 @default.
• W3037835402 cites W1980064899 @default.
• W3037835402 cites W1981110484 @default.
• W3037835402 cites W1991631628 @default.
• W3037835402 cites W2002015567 @default.
• W3037835402 cites W2010740759 @default.
• W3037835402 cites W2014778419 @default.
• W3037835402 cites W2015230474 @default.
• W3037835402 cites W2024649120 @default.
• W3037835402 cites W2035019741 @default.
• W3037835402 cites W2040734236 @default.
• W3037835402 cites W2044559973 @default.
• W3037835402 cites W2055823448 @default.
• W3037835402 cites W2058205407 @default.
• W3037835402 cites W2063863839 @default.
• W3037835402 cites W2066704041 @default.
• W3037835402 cites W2072052244 @default.
• W3037835402 cites W2074954748 @default.
• W3037835402 cites W2078849828 @default.
• W3037835402 cites W2081043801 @default.
• W3037835402 cites W2102161788 @default.
• W3037835402 cites W2103621763 @default.
• W3037835402 cites W2107652148 @default.
• W3037835402 cites W2109429564 @default.
• W3037835402 cites W2109533280 @default.
• W3037835402 cites W2114003436 @default.
• W3037835402 cites W2121792680 @default.
• W3037835402 cites W2122665731 @default.
• W3037835402 cites W2125996889 @default.
• W3037835402 cites W2128520408 @default.
• W3037835402 cites W2136518594 @default.
• W3037835402 cites W2145530136 @default.
• W3037835402 cites W2152725356 @default.
• W3037835402 cites W2164122959 @default.
• W3037835402 cites W2192574210 @default.
• W3037835402 cites W2298175511 @default.
• W3037835402 cites W2337483576 @default.
• W3037835402 cites W2345112450 @default.
• W3037835402 cites W2399674801 @default.
• W3037835402 cites W2604382703 @default.
• W3037835402 cites W2606382560 @default.
• W3037835402 cites W2611933195 @default.
• W3037835402 cites W2613820968 @default.
• W3037835402 cites W2637015637 @default.
• W3037835402 cites W2768594698 @default.
• W3037835402 cites W2771328536 @default.
• W3037835402 cites W2791419854 @default.
• W3037835402 cites W2791849171 @default.
• W3037835402 cites W2792530460 @default.
• W3037835402 cites W2811148342 @default.
• W3037835402 cites W2911972475 @default.
• W3037835402 cites W2972819506 @default.
• W3037835402 cites W4296816736 @default.
• W3037835402 cites W561888050 @default.
• W3037835402 cites W988766123 @default.
• W3037835402 doi "https://doi.org/10.1111/bph.15175" @default.
• W3037835402 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7680011" @default.
• W3037835402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32579243" @default.
• W3037835402 hasPublicationYear "2020" @default.
• W3037835402 type Work @default.
• W3037835402 sameAs 3037835402 @default.
• W3037835402 citedByCount "16" @default.
• W3037835402 countsByYear W30378354022020 @default.
• W3037835402 countsByYear W30378354022021 @default.
• W3037835402 countsByYear W30378354022022 @default.
• W3037835402 countsByYear W30378354022023 @default.
• W3037835402 crossrefType "journal-article" @default.
• W3037835402 hasAuthorship W3037835402A5026685209 @default.
• W3037835402 hasAuthorship W3037835402A5035304411 @default.
• W3037835402 hasAuthorship W3037835402A5041348573 @default.
• W3037835402 hasAuthorship W3037835402A5065442504 @default.
• W3037835402 hasAuthorship W3037835402A5067582597 @default.
• W3037835402 hasAuthorship W3037835402A5067588058 @default.
• W3037835402 hasAuthorship W3037835402A5073923353 @default.
• W3037835402 hasAuthorship W3037835402A5077935418 @default.
• W3037835402 hasAuthorship W3037835402A5080380147 @default.
• W3037835402 hasAuthorship W3037835402A5082912293 @default.

• next