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• W3037844866 endingPage "1991" @default.
• W3037844866 startingPage "1985" @default.
• W3037844866 abstract "An extra X chromosome occurs in ~ 1 in 1000 females, resulting in a karyotype 47,XXX also known as trisomy X syndrome (TXS). Women with TXS appear to be at increased risk for premature ovarian insufficiency; however, very little research on this relationship has been conducted. The objective of this case-control study is to compare ovarian function, as measured by anti-mullerian hormone (AMH) levels, between girls with TXS and controls. Serum AMH concentrations were compared between 15 females with TXS (median age 13.4 years) and 26 controls (median age 15.1 years). Females with TXS had significantly lower serum AMH compared to controls (0.7 ng/mL (IQR 0.2-1.7) vs 2.7 (IQR 1.3-4.8), p < 0.001). Additionally, girls with TXS were much more likely to have an AMH below the 2.5th percentile for age with 67% of them meeting these criteria (OR 11, 95% CI 2.3-42). Lower AMH concentrations in females with TXS may represent an increased risk for primary ovarian insufficiency in these patients and potentially a narrow window of opportunity to pursue fertility preservation options. Additional research is needed to understand the natural history of low AMH concentrations and future risk of premature ovarian insufficiency in girls with TXS." @default.
• W3037844866 created "2020-07-02" @default.
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• W3037844866 date "2020-06-23" @default.
• W3037844866 modified "2023-10-17" @default.
• W3037844866 title "Diminished Ovarian Reserve in Girls and Adolescents with Trisomy X Syndrome" @default.
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• W3037844866 doi "https://doi.org/10.1007/s43032-020-00216-4" @default.
• W3037844866 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7529937" @default.
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