FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037855461> ?p ?o ?g. }

• W3037855461 endingPage "118010" @default.
• W3037855461 startingPage "118010" @default.
• W3037855461 abstract "Podocyte injury is an early event and core in the development of focal segmental glomerular sclerosis (FSGS) that induces poor prognosis. Epithelial-mesenchymal transition (EMT) as a response of podocyte to injury leads to podocyte depletion and proteinuria. The abnormally reactivated NOTCH pathway may be involved in podocyte EMT. Baicalin, as a natural flavonoid compound, had significant inhibitory activity on tissue fibrosis and tumor cell invasion. However, its potential role and molecular mechanisms to injured podocyte in FSGS are little known. Here we found that baicalin could inhibit podocyte EMT markers expression and cell migration induced by TGF-β1, accompanied by the up-regulated expression of slit diaphragm (SD) proteins and cell-cell adhesion molecule. Further investigation revealed that EMT inhibition of baicalin on injured podocyte is mainly mediated by the reduction of notch1 activation and its downstream Snail expression. Using the adriamycin-induced FSGS model, we determined that baicalin suppresses the Notch1-Snail axis activation in podocytes, relieves glomerulus structural disruption and dysfunction, and reduces proteinuria. Altogether, these findings suggest that baicalin is a novel renoprotective agent against podocyte EMT in FSGS and indicate its underlying mechanism that involves in negative regulation of the Notch1-Snail axis." @default.
• W3037855461 created "2020-07-02" @default.
• W3037855461 creator A5017223285 @default.
• W3037855461 creator A5024242005 @default.
• W3037855461 creator A5024628817 @default.
• W3037855461 creator A5035941526 @default.
• W3037855461 creator A5039960714 @default.
• W3037855461 creator A5064528315 @default.
• W3037855461 date "2020-09-01" @default.
• W3037855461 modified "2023-10-15" @default.
• W3037855461 title "Baicalin alleviates adriamycin-induced focal segmental glomerulosclerosis and proteinuria by inhibiting the Notch1-Snail axis mediated podocyte EMT" @default.
• W3037855461 cites W1508437190 @default.
• W3037855461 cites W1549139000 @default.
• W3037855461 cites W1971498397 @default.
• W3037855461 cites W1978127755 @default.
• W3037855461 cites W1982639695 @default.
• W3037855461 cites W1990694891 @default.
• W3037855461 cites W1999275234 @default.
• W3037855461 cites W1999692238 @default.
• W3037855461 cites W2053841715 @default.
• W3037855461 cites W2082220621 @default.
• W3037855461 cites W2097041991 @default.
• W3037855461 cites W2103777275 @default.
• W3037855461 cites W2105361659 @default.
• W3037855461 cites W2125961014 @default.
• W3037855461 cites W2152808672 @default.
• W3037855461 cites W2159669836 @default.
• W3037855461 cites W2160109224 @default.
• W3037855461 cites W2274986638 @default.
• W3037855461 cites W2301340697 @default.
• W3037855461 cites W2593771998 @default.
• W3037855461 cites W2743657325 @default.
• W3037855461 cites W2786692418 @default.
• W3037855461 cites W2790735643 @default.
• W3037855461 cites W2804923938 @default.
• W3037855461 cites W2896667060 @default.
• W3037855461 cites W2898606030 @default.
• W3037855461 cites W2944982035 @default.
• W3037855461 cites W2947444821 @default.
• W3037855461 cites W2972465294 @default.
• W3037855461 cites W4211233744 @default.
• W3037855461 doi "https://doi.org/10.1016/j.lfs.2020.118010" @default.
• W3037855461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32598932" @default.
• W3037855461 hasPublicationYear "2020" @default.
• W3037855461 type Work @default.
• W3037855461 sameAs 3037855461 @default.
• W3037855461 citedByCount "15" @default.
• W3037855461 countsByYear W30378554612020 @default.
• W3037855461 countsByYear W30378554612021 @default.
• W3037855461 countsByYear W30378554612022 @default.
• W3037855461 countsByYear W30378554612023 @default.
• W3037855461 crossrefType "journal-article" @default.
• W3037855461 hasAuthorship W3037855461A5017223285 @default.
• W3037855461 hasAuthorship W3037855461A5024242005 @default.
• W3037855461 hasAuthorship W3037855461A5024628817 @default.
• W3037855461 hasAuthorship W3037855461A5035941526 @default.
• W3037855461 hasAuthorship W3037855461A5039960714 @default.
• W3037855461 hasAuthorship W3037855461A5064528315 @default.
• W3037855461 hasConcept C126322002 @default.
• W3037855461 hasConcept C179998833 @default.
• W3037855461 hasConcept C185592680 @default.
• W3037855461 hasConcept C2777146197 @default.
• W3037855461 hasConcept C2777390665 @default.
• W3037855461 hasConcept C2778415529 @default.
• W3037855461 hasConcept C2779561371 @default.
• W3037855461 hasConcept C2780091579 @default.
• W3037855461 hasConcept C2780113650 @default.
• W3037855461 hasConcept C3018201436 @default.
• W3037855461 hasConcept C43617362 @default.
• W3037855461 hasConcept C502942594 @default.
• W3037855461 hasConcept C71924100 @default.
• W3037855461 hasConcept C86803240 @default.
• W3037855461 hasConcept C95444343 @default.
• W3037855461 hasConceptScore W3037855461C126322002 @default.
• W3037855461 hasConceptScore W3037855461C179998833 @default.
• W3037855461 hasConceptScore W3037855461C185592680 @default.
• W3037855461 hasConceptScore W3037855461C2777146197 @default.
• W3037855461 hasConceptScore W3037855461C2777390665 @default.
• W3037855461 hasConceptScore W3037855461C2778415529 @default.
• W3037855461 hasConceptScore W3037855461C2779561371 @default.
• W3037855461 hasConceptScore W3037855461C2780091579 @default.
• W3037855461 hasConceptScore W3037855461C2780113650 @default.
• W3037855461 hasConceptScore W3037855461C3018201436 @default.
• W3037855461 hasConceptScore W3037855461C43617362 @default.
• W3037855461 hasConceptScore W3037855461C502942594 @default.
• W3037855461 hasConceptScore W3037855461C71924100 @default.
• W3037855461 hasConceptScore W3037855461C86803240 @default.
• W3037855461 hasConceptScore W3037855461C95444343 @default.
• W3037855461 hasFunder F4320321001 @default.
• W3037855461 hasFunder F4320326709 @default.
• W3037855461 hasLocation W30378554611 @default.
• W3037855461 hasLocation W30378554612 @default.
• W3037855461 hasOpenAccess W3037855461 @default.
• W3037855461 hasPrimaryLocation W30378554611 @default.
• W3037855461 hasRelatedWork W1511867626 @default.
• W3037855461 hasRelatedWork W1974158148 @default.
• W3037855461 hasRelatedWork W2035696747 @default.
• W3037855461 hasRelatedWork W2057102699 @default.

• next