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• W3037876215 abstract "Background Short‐term memory binding (STMB) tests assess conjunctive binding, in which participants should remember the integration of features, such as shapes (or objects) and colors, forming a unique representation in memory. In this study, we investigated two STMB paradigms: change detection (CD) and free recall (FR). Objective To investigate the cognitive profile in the CD and FR tasks of three diagnostic groups: cognitively unimpaired (CU), mild cognitive impairment (MCI), and Alzheimer's clinical syndrome (ACS). In addition, we aimed to calculate and compare the accuracy of the CD and FR tasks to identify MCI and ACS. Methods Participants were 24 CU, 24 MCI, and 37 ACS. The cognitive scores of the clinical groups were compared using analysis of variance (ANOVA) and receiver‐operating characteristic (ROC) analyses were carried out to verify the accuracy of the STMB tasks. Results In the CD task, CU was different from MCI and ACS (CU > MCI = ACS), while in the FR task all groups were different (CU > MCI > ACS). The ROC analyses showed an area under the curve (AUC) of 0.855 comparing CU with MCI for the CD task and 0.975 for the FR. The AUC comparing CU and ACS was 0.924 for the CD and 0.973 for the FR task. The FR task showed better accuracy to identify MCI patients, and the same accuracy to detect ACS. Conclusion The present findings indicate that impairments in CD and FR of bound representations are features of the cognitive profiles of MCI and ACS patients." @default.
• W3037876215 created "2020-07-02" @default.
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• W3037876215 date "2020-07-24" @default.
• W3037876215 modified "2023-10-17" @default.
• W3037876215 title "Profiles of cognitive impairment in the continuum from normal cognition to Alzheimer's clinical syndrome: Contributions of the short‐term memory binding tests" @default.
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• W3037876215 doi "https://doi.org/10.1002/gps.5370" @default.
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