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- W3037894769 startingPage "115115" @default.
- W3037894769 abstract "Though invertebrates are one of the largest groups of animal species in the sea and exhibit robust immune and neural responses that are crucial for their health and survival, the potential immunotoxicity and neurotoxicity of the most produced chemical bisphenol A (BPA), especially in conjunction with microplastics (MPs), still remain poorly understood in marine invertebrate species. Therefore, the impacts of exposure to BPA and MPs alone or in combination on a series of immune and neural biomarkers were investigated in the invertebrate bivalve species blood clam (Tegillarca granosa). Evident immunotoxicity as indicated by alterations in hematic indexes was observed after two weeks of exposure to BPA and MPs at environmentally realistic concentrations. The expression of four immune-related genes from the NFκB signaling pathway was also found to be significantly suppressed by the BPA and MP treatment. In addition, exposure to BPA and MPs led to an increase in the in vivo contents of three key neurotransmitters (GABA, DA, and ACh) but a decrease in the expression of genes encoding modulatory enzymes and receptors for these neurotransmitters, implying the evident neurotoxicity of BPA and MPs to blood clam. Furthermore, the results demonstrated that the toxic impacts exerted by BPA were significantly aggravated by the co-presence of MPs, which may be due to interactions between BPA and MPs as well as those between MPs and clam individuals." @default.
- W3037894769 created "2020-07-02" @default.
- W3037894769 creator A5004494343 @default.
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- W3037894769 creator A5091448543 @default.
- W3037894769 creator A5091470716 @default.
- W3037894769 date "2020-10-01" @default.
- W3037894769 modified "2023-10-06" @default.
- W3037894769 title "Immunotoxicity and neurotoxicity of bisphenol A and microplastics alone or in combination to a bivalve species, Tegillarca granosa" @default.
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