FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037895802> ?p ?o ?g. }

• W3037895802 endingPage "4532" @default.
• W3037895802 startingPage "4532" @default.
• W3037895802 abstract "Alzheimer’s disease (AD) is the most common type of dementia. AD involves major pathologies such as amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. During the progression of AD, microglia can be polarized from anti-inflammatory M2 to pro-inflammatory M1 phenotype. The activation of triggering receptor expressed on myeloid cells 2 (TREM2) may result in microglia phenotype switching from M1 to M2, which finally attenuated Aβ deposition and memory loss in AD. Low-dose ionizing radiation (LDIR) is known to ameliorate Aβ pathology and cognitive deficits in AD; however, the therapeutic mechanisms of LDIR against AD-related pathology have been little studied. First, we reconfirm that LDIR (two Gy per fraction for five times)-treated six-month 5XFAD mice exhibited (1) the reduction of Aβ deposition, as reflected by thioflavins S staining, and (2) the improvement of cognitive deficits, as revealed by Morris water maze test, compared to sham-exposed 5XFAD mice. To elucidate the mechanisms of LDIR-induced inhibition of Aβ accumulation and memory loss in AD, we examined whether LDIR regulates the microglial phenotype through the examination of levels of M1 and M2 cytokines in 5XFAD mice. In addition, we investigated the direct effects of LDIR on lipopolysaccharide (LPS)-induced production and secretion of M1/M2 cytokines in the BV-2 microglial cells. In the LPS- and LDIR-treated BV-2 cells, the M2 phenotypic marker CD206 was significantly increased, compared with LPS- and sham-treated BV-2 cells. Finally, the effect of LDIR on M2 polarization was confirmed by detection of increased expression of TREM2 in LPS-induced BV2 cells. These results suggest that LDIR directly induced phenotype switching from M1 to M2 in the brain with AD. Taken together, our results indicated that LDIR modulates LPS- and Aβ-induced neuroinflammation by promoting M2 polarization via TREM2 expression, and has beneficial effects in the AD-related pathology such as Aβ deposition and memory loss." @default.
• W3037895802 created "2020-07-02" @default.
• W3037895802 creator A5001575541 @default.
• W3037895802 creator A5013430395 @default.
• W3037895802 creator A5017544364 @default.
• W3037895802 creator A5021812132 @default.
• W3037895802 creator A5037520538 @default.
• W3037895802 creator A5041628251 @default.
• W3037895802 creator A5042114771 @default.
• W3037895802 creator A5044398103 @default.
• W3037895802 creator A5051589591 @default.
• W3037895802 creator A5054840167 @default.
• W3037895802 creator A5059830079 @default.
• W3037895802 creator A5062890965 @default.
• W3037895802 creator A5067272028 @default.
• W3037895802 creator A5073718739 @default.
• W3037895802 creator A5090988274 @default.
• W3037895802 date "2020-06-25" @default.
• W3037895802 modified "2023-10-09" @default.
• W3037895802 title "Low-Dose Ionizing Radiation Modulates Microglia Phenotypes in the Models of Alzheimer’s Disease" @default.
• W3037895802 cites W1978681592 @default.
• W3037895802 cites W1987037769 @default.
• W3037895802 cites W1987256681 @default.
• W3037895802 cites W1990364980 @default.
• W3037895802 cites W1993540177 @default.
• W3037895802 cites W1994580609 @default.
• W3037895802 cites W2002812377 @default.
• W3037895802 cites W2004349171 @default.
• W3037895802 cites W2008501852 @default.
• W3037895802 cites W2011041653 @default.
• W3037895802 cites W2017831868 @default.
• W3037895802 cites W2023136593 @default.
• W3037895802 cites W2034066410 @default.
• W3037895802 cites W2036292064 @default.
• W3037895802 cites W2038870006 @default.
• W3037895802 cites W2050320551 @default.
• W3037895802 cites W2050326967 @default.
• W3037895802 cites W2053974741 @default.
• W3037895802 cites W2056958351 @default.
• W3037895802 cites W2069893872 @default.
• W3037895802 cites W2087291502 @default.
• W3037895802 cites W2093381644 @default.
• W3037895802 cites W2098137179 @default.
• W3037895802 cites W2099157718 @default.
• W3037895802 cites W2100592123 @default.
• W3037895802 cites W2106877460 @default.
• W3037895802 cites W2107277218 @default.
• W3037895802 cites W2108435419 @default.
• W3037895802 cites W2114829829 @default.
• W3037895802 cites W2117437970 @default.
• W3037895802 cites W2122000781 @default.
• W3037895802 cites W2122939482 @default.
• W3037895802 cites W2124490243 @default.
• W3037895802 cites W2124836944 @default.
• W3037895802 cites W2124905160 @default.
• W3037895802 cites W2125393554 @default.
• W3037895802 cites W2128492849 @default.
• W3037895802 cites W2146200408 @default.
• W3037895802 cites W2151422561 @default.
• W3037895802 cites W2155109894 @default.
• W3037895802 cites W2155344647 @default.
• W3037895802 cites W2170107264 @default.
• W3037895802 cites W2170959966 @default.
• W3037895802 cites W2227174375 @default.
• W3037895802 cites W2246389678 @default.
• W3037895802 cites W2296704298 @default.
• W3037895802 cites W2298610985 @default.
• W3037895802 cites W2301044272 @default.
• W3037895802 cites W2307324788 @default.
• W3037895802 cites W2327283732 @default.
• W3037895802 cites W2341828158 @default.
• W3037895802 cites W2358666620 @default.
• W3037895802 cites W2462662422 @default.
• W3037895802 cites W2521772559 @default.
• W3037895802 cites W2526118213 @default.
• W3037895802 cites W2527645962 @default.
• W3037895802 cites W2564960958 @default.
• W3037895802 cites W2589440020 @default.
• W3037895802 cites W2604882706 @default.
• W3037895802 cites W2606471454 @default.
• W3037895802 cites W2616532944 @default.
• W3037895802 cites W2622807556 @default.
• W3037895802 cites W2666896214 @default.
• W3037895802 cites W2738752894 @default.
• W3037895802 cites W2745998250 @default.
• W3037895802 cites W2750718695 @default.
• W3037895802 cites W2753715211 @default.
• W3037895802 cites W2754890392 @default.
• W3037895802 cites W2758511500 @default.
• W3037895802 cites W2789258764 @default.
• W3037895802 cites W2790983771 @default.
• W3037895802 cites W2791441382 @default.
• W3037895802 cites W2791832923 @default.
• W3037895802 cites W2796284128 @default.
• W3037895802 cites W2883628966 @default.
• W3037895802 cites W2884070953 @default.
• W3037895802 cites W2885688005 @default.
• W3037895802 cites W2889504770 @default.

• next