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- W3037920250 endingPage "5099" @default.
- W3037920250 startingPage "5079" @default.
- W3037920250 abstract "Human immunodeficiency virus type 1 (HIV-1) transactivator of transcription (Tat) is a potent mediator involved in the development of HIV-1-associated neurocognitive disorders (HAND). Tat is expressed even in the presence of antiretroviral therapy (ART) and is able to enter the central nervous system (CNS) through a variety of ways, where Tat can interact with microglia, astrocytes, brain microvascular endothelial cells, and neurons. The presence of low concentrations of extracellular Tat alone has been shown to lead to dysregulated gene expression, chronic cell activation, inflammation, neurotoxicity, and structural damage in the brain. The reported effects of Tat are dependent in part on the specific HIV-1 subtype and amino acid length of Tat used. HIV-1 subtype B Tat is the most common subtype in North American and therefore, most studies have been focused on subtype B Tat; however, studies have shown many genetic, biologic, and pathologic differences between HIV subtype B and subtype C Tat. This review will focus primarily on subtype B Tat where the full-length protein is 101 amino acids, but will also consider variants of Tat, such as Tat 72 and Tat 86, that have been reported to exhibit a number of distinctive activities with respect to mediating CNS damage and neurotoxicity." @default.
- W3037920250 created "2020-07-02" @default.
- W3037920250 creator A5022311253 @default.
- W3037920250 creator A5034657105 @default.
- W3037920250 creator A5051546937 @default.
- W3037920250 creator A5054582695 @default.
- W3037920250 creator A5069430740 @default.
- W3037920250 creator A5079331165 @default.
- W3037920250 date "2020-06-23" @default.
- W3037920250 modified "2023-10-17" @default.
- W3037920250 title "Functional impact of HIV-1 Tat on cells of the CNS and its role in HAND" @default.
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