Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037922689> ?p ?o ?g. }
- W3037922689 endingPage "24" @default.
- W3037922689 startingPage "24" @default.
- W3037922689 abstract "Long noncoding RNAs (lncRNAs) are RNAs with a length of over 200 nucleotides that do not have protein-coding abilities. Recent studies suggest that lncRNAs are highly involved in physiological functions and diseases. lncRNAs HNF1α-AS1 and HNF4α-AS1 are transcripts of lncRNA genes HNF1α-AS1 and HNF4α-AS1, which are antisense lncRNA genes located in the neighborhood regions of the transcription factor (TF) genes HNF1α and HNF4α, respectively. HNF1α-AS1 and HNF4α-AS1 have been reported to be involved in several important functions in human physiological activities and diseases. In the liver, HNF1α-AS1 and HNF4α-AS1 regulate the expression and function of several drug-metabolizing cytochrome P450 (P450) enzymes, which also further impact P450-mediated drug metabolism and drug toxicity. In addition, HNF1α-AS1 and HNF4α-AS1 also play important roles in the tumorigenesis, progression, invasion, and treatment outcome of several cancers. Through interacting with different molecules, including miRNAs and proteins, HNF1α-AS1 and HNF4α-AS1 can regulate their target genes in several different mechanisms including miRNA sponge, decoy, or scaffold. The purpose of the current review is to summarize the identified functions and mechanisms of HNF1α-AS1 and HNF4α-AS1 and to discuss the future directions of research of these two lncRNAs." @default.
- W3037922689 created "2020-07-02" @default.
- W3037922689 creator A5016071399 @default.
- W3037922689 creator A5030329823 @default.
- W3037922689 creator A5037480567 @default.
- W3037922689 creator A5058280837 @default.
- W3037922689 date "2020-06-24" @default.
- W3037922689 modified "2023-09-26" @default.
- W3037922689 title "The Roles of Long Noncoding RNAs HNF1α-AS1 and HNF4α-AS1 in Drug Metabolism and Human Diseases" @default.
- W3037922689 cites W1542426682 @default.
- W3037922689 cites W1550637999 @default.
- W3037922689 cites W1686333409 @default.
- W3037922689 cites W1793796070 @default.
- W3037922689 cites W1868198369 @default.
- W3037922689 cites W1966498224 @default.
- W3037922689 cites W1980306443 @default.
- W3037922689 cites W1986614590 @default.
- W3037922689 cites W1988730842 @default.
- W3037922689 cites W1988896110 @default.
- W3037922689 cites W1989816222 @default.
- W3037922689 cites W1995777485 @default.
- W3037922689 cites W1997794911 @default.
- W3037922689 cites W1999746344 @default.
- W3037922689 cites W2000068256 @default.
- W3037922689 cites W2015707272 @default.
- W3037922689 cites W2016830527 @default.
- W3037922689 cites W2018838463 @default.
- W3037922689 cites W2026514323 @default.
- W3037922689 cites W2027807256 @default.
- W3037922689 cites W2029919331 @default.
- W3037922689 cites W2031980581 @default.
- W3037922689 cites W2034269591 @default.
- W3037922689 cites W2043317822 @default.
- W3037922689 cites W2047911339 @default.
- W3037922689 cites W2049800228 @default.
- W3037922689 cites W2050836341 @default.
- W3037922689 cites W2051282896 @default.
- W3037922689 cites W2051911149 @default.
- W3037922689 cites W2052943334 @default.
- W3037922689 cites W2067922543 @default.
- W3037922689 cites W2071271349 @default.
- W3037922689 cites W2077655287 @default.
- W3037922689 cites W2079983771 @default.
- W3037922689 cites W2083543262 @default.
- W3037922689 cites W2087587381 @default.
- W3037922689 cites W2095311108 @default.
- W3037922689 cites W2105349784 @default.
- W3037922689 cites W2110985188 @default.
- W3037922689 cites W2111839080 @default.
- W3037922689 cites W2112059119 @default.
- W3037922689 cites W2116306122 @default.
- W3037922689 cites W2121352589 @default.
- W3037922689 cites W2123066359 @default.
- W3037922689 cites W2126504590 @default.
- W3037922689 cites W2128876691 @default.
- W3037922689 cites W2130313087 @default.
- W3037922689 cites W2138884188 @default.
- W3037922689 cites W2141337702 @default.
- W3037922689 cites W2141793095 @default.
- W3037922689 cites W2143642267 @default.
- W3037922689 cites W2150006612 @default.
- W3037922689 cites W2162547088 @default.
- W3037922689 cites W2169302611 @default.
- W3037922689 cites W2170037930 @default.
- W3037922689 cites W2176555004 @default.
- W3037922689 cites W2187223551 @default.
- W3037922689 cites W2192025959 @default.
- W3037922689 cites W2207330310 @default.
- W3037922689 cites W2239613263 @default.
- W3037922689 cites W2245239316 @default.
- W3037922689 cites W2259938310 @default.
- W3037922689 cites W2264951480 @default.
- W3037922689 cites W2270068380 @default.
- W3037922689 cites W2285675605 @default.
- W3037922689 cites W2289023840 @default.
- W3037922689 cites W2291340556 @default.
- W3037922689 cites W2316572014 @default.
- W3037922689 cites W2323028794 @default.
- W3037922689 cites W2331295779 @default.
- W3037922689 cites W2339820296 @default.
- W3037922689 cites W2346206641 @default.
- W3037922689 cites W2502698579 @default.
- W3037922689 cites W2509925948 @default.
- W3037922689 cites W2538724037 @default.
- W3037922689 cites W2539098207 @default.
- W3037922689 cites W2584563445 @default.
- W3037922689 cites W2591601044 @default.
- W3037922689 cites W2594799047 @default.
- W3037922689 cites W2603752903 @default.
- W3037922689 cites W2605170033 @default.
- W3037922689 cites W2606463011 @default.
- W3037922689 cites W2615786037 @default.
- W3037922689 cites W2744996861 @default.
- W3037922689 cites W2749625238 @default.
- W3037922689 cites W2751440418 @default.
- W3037922689 cites W2753482964 @default.
- W3037922689 cites W2758137281 @default.
- W3037922689 cites W2759277335 @default.