Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037928095> ?p ?o ?g. }
- W3037928095 endingPage "4591" @default.
- W3037928095 startingPage "4591" @default.
- W3037928095 abstract "Clusterin exerts anti-inflammatory, cytoprotective and anti-apoptotic effects. Both an increase and decrease of clusterin in acute myocardial infarction (AMI) has been reported. We aimed to clarify the role of clusterin as a systemic biomarker in AMI. AMI was induced by percutaneous left anterior artery (LAD) occlusion for 90 min followed by reperfusion in 24 pigs. Contrast ventriculography was performed after reperfusion to assess left ventricular ejection fraction (LVEF), left ventricular end diastolic volume (LVEDV) and left ventricular end systolic volume (LVESV) and additional cMRI + late enhancement to measure infarct size and LV functions at day 3 and week 6 post-MI. Blood samples were collected at prespecified timepoints. Plasma clusterin and other biomarkers (cTnT, NT-proBNP, neprilysin, NGAL, ET-1, osteopontin, miR21, miR29) were measured by ELISA and qPCR. Gene expression profiles of infarcted and remote region 3 h (n = 5) and 3 days (n = 5) after AMI onset were analysed by RNA-sequencing. AMI led to an increase in LVEDV and LVESV during 6-week, with concomitant elevation of NT-proBNP 3-weeks after AMI. Plasma clusterin levels were increased immediately after AMI and returned to normal levels until 3-weeks. Plasma NGAL, ET-1 and miR29 was significantly elevated at 3 weeks follow-up, miR21 increased after reperfusion and at 3 weeks post-AMI, while circulating neprilysin levels did not change. Elevated plasma clusterin levels 120 min after AMI onset suggest that clusterin might be an additional early biomarker of myocardial ischemia." @default.
- W3037928095 created "2020-07-02" @default.
- W3037928095 creator A5001769729 @default.
- W3037928095 creator A5019910434 @default.
- W3037928095 creator A5029399156 @default.
- W3037928095 creator A5036933034 @default.
- W3037928095 creator A5046463804 @default.
- W3037928095 creator A5075729056 @default.
- W3037928095 creator A5079547334 @default.
- W3037928095 creator A5081278197 @default.
- W3037928095 creator A5084343295 @default.
- W3037928095 creator A5084753942 @default.
- W3037928095 creator A5065465301 @default.
- W3037928095 date "2020-06-28" @default.
- W3037928095 modified "2023-09-24" @default.
- W3037928095 title "Early Elevation of Systemic Plasma Clusterin after Reperfused Acute Myocardial Infarction in a Preclinical Porcine Model of Ischemic Heart Disease" @default.
- W3037928095 cites W1088895628 @default.
- W3037928095 cites W1502053360 @default.
- W3037928095 cites W1562375076 @default.
- W3037928095 cites W1968853064 @default.
- W3037928095 cites W1977331514 @default.
- W3037928095 cites W1978480398 @default.
- W3037928095 cites W1986451738 @default.
- W3037928095 cites W2000949542 @default.
- W3037928095 cites W2010466622 @default.
- W3037928095 cites W2011854030 @default.
- W3037928095 cites W2012795446 @default.
- W3037928095 cites W2013851619 @default.
- W3037928095 cites W2014792775 @default.
- W3037928095 cites W2016164685 @default.
- W3037928095 cites W2022852324 @default.
- W3037928095 cites W2026515462 @default.
- W3037928095 cites W2035048988 @default.
- W3037928095 cites W2036158870 @default.
- W3037928095 cites W2036876430 @default.
- W3037928095 cites W2039767184 @default.
- W3037928095 cites W2051842535 @default.
- W3037928095 cites W2052407739 @default.
- W3037928095 cites W2075277681 @default.
- W3037928095 cites W2077202666 @default.
- W3037928095 cites W2096663595 @default.
- W3037928095 cites W2098002403 @default.
- W3037928095 cites W2105397247 @default.
- W3037928095 cites W2108076556 @default.
- W3037928095 cites W2115898766 @default.
- W3037928095 cites W2124664054 @default.
- W3037928095 cites W2132093971 @default.
- W3037928095 cites W2155290141 @default.
- W3037928095 cites W2156448907 @default.
- W3037928095 cites W2156715310 @default.
- W3037928095 cites W2158635438 @default.
- W3037928095 cites W2162804111 @default.
- W3037928095 cites W2166302350 @default.
- W3037928095 cites W2166950143 @default.
- W3037928095 cites W2168412436 @default.
- W3037928095 cites W2343133808 @default.
- W3037928095 cites W2475677373 @default.
- W3037928095 cites W2549777547 @default.
- W3037928095 cites W2594422776 @default.
- W3037928095 cites W2625241337 @default.
- W3037928095 cites W2761290171 @default.
- W3037928095 cites W2765167648 @default.
- W3037928095 cites W2790849506 @default.
- W3037928095 cites W2808487639 @default.
- W3037928095 cites W2814616126 @default.
- W3037928095 cites W2895589661 @default.
- W3037928095 cites W2909474730 @default.
- W3037928095 cites W2941606035 @default.
- W3037928095 cites W3003360215 @default.
- W3037928095 cites W3004585086 @default.
- W3037928095 cites W3012997399 @default.
- W3037928095 cites W4245265700 @default.
- W3037928095 doi "https://doi.org/10.3390/ijms21134591" @default.
- W3037928095 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7369988" @default.
- W3037928095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32605184" @default.
- W3037928095 hasPublicationYear "2020" @default.
- W3037928095 type Work @default.
- W3037928095 sameAs 3037928095 @default.
- W3037928095 citedByCount "3" @default.
- W3037928095 countsByYear W30379280952023 @default.
- W3037928095 crossrefType "journal-article" @default.
- W3037928095 hasAuthorship W3037928095A5001769729 @default.
- W3037928095 hasAuthorship W3037928095A5019910434 @default.
- W3037928095 hasAuthorship W3037928095A5029399156 @default.
- W3037928095 hasAuthorship W3037928095A5036933034 @default.
- W3037928095 hasAuthorship W3037928095A5046463804 @default.
- W3037928095 hasAuthorship W3037928095A5065465301 @default.
- W3037928095 hasAuthorship W3037928095A5075729056 @default.
- W3037928095 hasAuthorship W3037928095A5079547334 @default.
- W3037928095 hasAuthorship W3037928095A5081278197 @default.
- W3037928095 hasAuthorship W3037928095A5084343295 @default.
- W3037928095 hasAuthorship W3037928095A5084753942 @default.
- W3037928095 hasBestOaLocation W30379280951 @default.
- W3037928095 hasConcept C126322002 @default.
- W3037928095 hasConcept C164705383 @default.
- W3037928095 hasConcept C185592680 @default.
- W3037928095 hasConcept C190283241 @default.
- W3037928095 hasConcept C2778198053 @default.