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• W3037928384 endingPage "12" @default.
• W3037928384 startingPage "1" @default.
• W3037928384 abstract "Nephropathic patients show elevated cardiovascular morbidity and mortality compared to the general population. In order to delve deeper into the understanding of this phenomenon, it is necessary to recognize risk factors that are distinctive to the uremic state, such as oxidative stress and chronic low-grade inflammation. Moreover, gender differences have been reported in nephrology, as it has been observed that chronic kidney disease has higher prevalence in males than in females. The use of an oral food supplement (OFS) containing natural active compounds from Capsicum annuum L., Garcinia cambogia, Centella asiatica L., artichoke, and Aesculus hippocastanum L. which are virtually devoid from side effects, but rich in antioxidant and antiradical properties, could represent a valid therapeutic adjunct in the clinical management of nephropathic patients. Moreover, quantitative analysis performed in vitro on such compounds showed that they expressed good total antioxidant (7.28 gallic acid equivalents) and antiradical activity (above 80%). In this study, 23 male nephropathic patients and 10 age and body composition parameter matched healthy males (control group) were enrolled and took 3 cps/day of OFS for 5 weeks. At the end of the study, the nephropathic patient group showed a statistically significant reduction in the following laboratory parameters: total cholesterol (TC) (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.044</mml:mn></mml:math>), atherogenic index TC/high-density lipoprotein cholesterol (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.010</mml:mn></mml:math>), inflammatory parameters (C-reactive protein, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.048</mml:mn></mml:math>, and erythrocyte sedimentation rate, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.019</mml:mn></mml:math>), systolic (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.044</mml:mn></mml:math>), and diastolic arterial blood pressure (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.003</mml:mn></mml:math>). Regarding body composition, there was an increase in total body water % (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.035</mml:mn></mml:math>) with redistribution of extracellular water % (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.030</mml:mn></mml:math>) and intracellular water % (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.049</mml:mn></mml:math>). In the control group, there was a reduction in fat mass % (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M10><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.017</mml:mn></mml:math>) and extracellular water % (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M11><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.047</mml:mn></mml:math>). Therefore, this OFS may represent a valid adjunct therapy to counteract comorbidities related to uremia." @default.
• W3037928384 created "2020-07-02" @default.
• W3037928384 creator A5001506780 @default.
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• W3037928384 date "2020-06-25" @default.
• W3037928384 modified "2023-09-27" @default.
• W3037928384 title "Cardiovascular Protection of Nephropathic Male Patients by Oral Food Supplements" @default.
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