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- W3037929275 endingPage "128699" @default.
- W3037929275 startingPage "128699" @default.
- W3037929275 abstract "Stereoselective aldoximes, preferably Z form have been obtained from α-cyano substituted carbonyl conjugated alkenes. This reaction occurs through Michael addition type reaction followed by retro-Knoevenagel reaction without transition-metal catalysis via C–C bond cleavage. These oximes are evaluated against cancer cell lines employing mechanistic study. Two oximes showed significant cytotoxic activity, which through in silico studies were found to inhibit MRCK Kinase, responsible for metastatic spread of cancer mortality." @default.
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- W3037929275 date "2020-11-01" @default.
- W3037929275 modified "2023-10-03" @default.
- W3037929275 title "Water mediated procedure for preparation of stereoselective oximes as inhibitors of MRCK kinase" @default.
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- W3037929275 doi "https://doi.org/10.1016/j.molstruc.2020.128699" @default.
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