Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037937919> ?p ?o ?g. }
- W3037937919 abstract "Abstract Single-cell RNA sequencing is revealing an unexpectedly large degree of heterogeneity in gene expression levels across cell populations. However, little is known on the functional consequences of this heterogeneity and the contribution of individual cell fate decisions to the collective behavior of the tissues these cells are part of. Here, we use mechanistic modeling of signaling circuits, which reveals a complex functional landscape at single-cell level. Different clusters of neoplastic glioblastoma cells have been defined according to their differences in signaling circuit activity profiles triggering specific cancer hallmarks, which suggest different functional strategies with distinct degrees of aggressiveness. Moreover, mechanistic modeling of effects of targeted drug inhibitions at single-cell level revealed, how in some cells, the substitution of VEGFA, the target of bevacizumab, by other expressed proteins, like PDGFD, KITLG and FGF2, keeps the VEGF pathway active, insensitive to the VEGFA inhibition by the drug. Here, we describe for the first time mechanisms that individual cells use to avoid the effect of a targeted therapy, providing an explanation for the innate resistance to the treatment displayed by some cells. Our results suggest that mechanistic modeling could become an important asset for the definition of personalized therapeutic interventions." @default.
- W3037937919 created "2020-07-02" @default.
- W3037937919 creator A5005073322 @default.
- W3037937919 creator A5015858475 @default.
- W3037937919 creator A5021802977 @default.
- W3037937919 creator A5067601660 @default.
- W3037937919 creator A5068809376 @default.
- W3037937919 date "2020-06-01" @default.
- W3037937919 modified "2023-10-09" @default.
- W3037937919 title "Mechanistic models of signaling pathways deconvolute the glioblastoma single-cell functional landscape" @default.
- W3037937919 cites W1506994362 @default.
- W3037937919 cites W1813068103 @default.
- W3037937919 cites W1967327758 @default.
- W3037937919 cites W1973045287 @default.
- W3037937919 cites W1974227941 @default.
- W3037937919 cites W1979283544 @default.
- W3037937919 cites W1981509058 @default.
- W3037937919 cites W1986397618 @default.
- W3037937919 cites W1992003948 @default.
- W3037937919 cites W1992885568 @default.
- W3037937919 cites W1993287310 @default.
- W3037937919 cites W2006540875 @default.
- W3037937919 cites W2014368942 @default.
- W3037937919 cites W2029214079 @default.
- W3037937919 cites W2033403400 @default.
- W3037937919 cites W2065105173 @default.
- W3037937919 cites W2085264684 @default.
- W3037937919 cites W2093904762 @default.
- W3037937919 cites W2101547995 @default.
- W3037937919 cites W2112452933 @default.
- W3037937919 cites W2117692326 @default.
- W3037937919 cites W2124388496 @default.
- W3037937919 cites W2129815183 @default.
- W3037937919 cites W2130410032 @default.
- W3037937919 cites W2131848047 @default.
- W3037937919 cites W2134807618 @default.
- W3037937919 cites W2144683894 @default.
- W3037937919 cites W2145748272 @default.
- W3037937919 cites W2146512944 @default.
- W3037937919 cites W2161289668 @default.
- W3037937919 cites W2173807453 @default.
- W3037937919 cites W2197234859 @default.
- W3037937919 cites W2201254472 @default.
- W3037937919 cites W2267280007 @default.
- W3037937919 cites W2273101790 @default.
- W3037937919 cites W2346323658 @default.
- W3037937919 cites W2397617781 @default.
- W3037937919 cites W2509957998 @default.
- W3037937919 cites W2525203343 @default.
- W3037937919 cites W2528904141 @default.
- W3037937919 cites W2554863679 @default.
- W3037937919 cites W2566814726 @default.
- W3037937919 cites W2570618306 @default.
- W3037937919 cites W2573758209 @default.
- W3037937919 cites W2575704225 @default.
- W3037937919 cites W2601483252 @default.
- W3037937919 cites W2616922646 @default.
- W3037937919 cites W2621895366 @default.
- W3037937919 cites W2736047977 @default.
- W3037937919 cites W2738946651 @default.
- W3037937919 cites W2751468300 @default.
- W3037937919 cites W2757234574 @default.
- W3037937919 cites W2776140326 @default.
- W3037937919 cites W2785630001 @default.
- W3037937919 cites W2787729717 @default.
- W3037937919 cites W2792693509 @default.
- W3037937919 cites W2799441834 @default.
- W3037937919 cites W2800038547 @default.
- W3037937919 cites W2804047726 @default.
- W3037937919 cites W2804847416 @default.
- W3037937919 cites W2806412533 @default.
- W3037937919 cites W2884829270 @default.
- W3037937919 cites W2884901132 @default.
- W3037937919 cites W2888407647 @default.
- W3037937919 cites W2888698325 @default.
- W3037937919 cites W2913905713 @default.
- W3037937919 cites W2914023335 @default.
- W3037937919 cites W2914146213 @default.
- W3037937919 cites W2946078866 @default.
- W3037937919 cites W2949829455 @default.
- W3037937919 cites W2950595506 @default.
- W3037937919 cites W2951850020 @default.
- W3037937919 cites W2951880440 @default.
- W3037937919 cites W2952535935 @default.
- W3037937919 cites W2952699241 @default.
- W3037937919 cites W2955318914 @default.
- W3037937919 cites W2959566316 @default.
- W3037937919 cites W2965499764 @default.
- W3037937919 cites W2980245695 @default.
- W3037937919 cites W2982402044 @default.
- W3037937919 cites W2985487435 @default.
- W3037937919 cites W2987681697 @default.
- W3037937919 cites W3136918052 @default.
- W3037937919 cites W4212949515 @default.
- W3037937919 doi "https://doi.org/10.1093/narcan/zcaa011" @default.
- W3037937919 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8210212" @default.
- W3037937919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34316686" @default.
- W3037937919 hasPublicationYear "2020" @default.
- W3037937919 type Work @default.
- W3037937919 sameAs 3037937919 @default.