Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037940256> ?p ?o ?g. }
- W3037940256 endingPage "1172" @default.
- W3037940256 startingPage "1161" @default.
- W3037940256 abstract "Given the high incidence and excellent prognosis of many papillary thyroid microcarcinomas, the Porto proposal uses the designation papillary microtumor (PMT) for papillary microcarcinomas (PMCs) without risk factors to minimize overtreatment and patients' stress. To validate Porto proposal criteria, we examined a series of 190 PMC series, also studying sex hormone receptors and BRAFV600E mutation. Our updated Porto proposal (uPp) reclassifies as PMT incidental PMCs found at thyroidectomy lacking the following criteria: (a) detected under the age of 19 years; (b) with multiple tumors measuring >1 cm adding up all diameters; and (c) with aggressive morphologic features (extrathyroidal extension, angioinvasion, tall, and/or hobnail cells). PMCs not fulfilling uPp criteria were considered truePMCs. A total of 102 PMCs were subclassified as PMT, 88 as PMC, with no age or sex differences between subgroups. Total thyroidectomy and iodine-131 therapy were significantly more common in PMC. After a median follow-up of 9.6 years, lymph node metastases, distant metastases, and mortality were only found in the PMC subgroup. No subgroup differences were found in calcifications or desmoplasia. Expression of estrogen receptor-α and estrogen receptor-β, progesterone receptor, and androgen receptor was higher in PMC than in nontumorous thyroid tissue. BRAF mutations were detected in 44.7% of PMC, with no differences between subgroups. In surgical specimens, the uPp is a safe pathology tool to identify those PMC with extremely low malignant potential. This terminology could reduce psychological stress associated with cancer diagnosis, avoid overtreatment, and be incorporated into daily pathologic practice." @default.
- W3037940256 created "2020-07-02" @default.
- W3037940256 creator A5005191564 @default.
- W3037940256 creator A5008182923 @default.
- W3037940256 creator A5010222114 @default.
- W3037940256 creator A5023035236 @default.
- W3037940256 creator A5036546596 @default.
- W3037940256 creator A5041036500 @default.
- W3037940256 creator A5045098450 @default.
- W3037940256 creator A5057112774 @default.
- W3037940256 creator A5062529393 @default.
- W3037940256 creator A5074646858 @default.
- W3037940256 creator A5075852139 @default.
- W3037940256 creator A5079512209 @default.
- W3037940256 date "2020-06-23" @default.
- W3037940256 modified "2023-10-11" @default.
- W3037940256 title "Thyroid Papillary Microtumor" @default.
- W3037940256 cites W1154892096 @default.
- W3037940256 cites W1185126938 @default.
- W3037940256 cites W1436334267 @default.
- W3037940256 cites W1492602262 @default.
- W3037940256 cites W1848939527 @default.
- W3037940256 cites W1927033361 @default.
- W3037940256 cites W1979521363 @default.
- W3037940256 cites W1990797377 @default.
- W3037940256 cites W1993501912 @default.
- W3037940256 cites W1996386768 @default.
- W3037940256 cites W1997292934 @default.
- W3037940256 cites W1998203064 @default.
- W3037940256 cites W1999575673 @default.
- W3037940256 cites W2000041443 @default.
- W3037940256 cites W2007759528 @default.
- W3037940256 cites W2008087643 @default.
- W3037940256 cites W2013734001 @default.
- W3037940256 cites W2013989380 @default.
- W3037940256 cites W2020765303 @default.
- W3037940256 cites W2027424680 @default.
- W3037940256 cites W2033941366 @default.
- W3037940256 cites W2040268038 @default.
- W3037940256 cites W2046818976 @default.
- W3037940256 cites W2048228383 @default.
- W3037940256 cites W2054555153 @default.
- W3037940256 cites W2058954850 @default.
- W3037940256 cites W2059184796 @default.
- W3037940256 cites W2059928090 @default.
- W3037940256 cites W2062230158 @default.
- W3037940256 cites W2062878912 @default.
- W3037940256 cites W2064001243 @default.
- W3037940256 cites W2067461794 @default.
- W3037940256 cites W2072247653 @default.
- W3037940256 cites W2073893857 @default.
- W3037940256 cites W2085374657 @default.
- W3037940256 cites W2100583961 @default.
- W3037940256 cites W2102461279 @default.
- W3037940256 cites W2107334582 @default.
- W3037940256 cites W2108026237 @default.
- W3037940256 cites W2109909522 @default.
- W3037940256 cites W2111842257 @default.
- W3037940256 cites W2117321105 @default.
- W3037940256 cites W2118975300 @default.
- W3037940256 cites W2129034112 @default.
- W3037940256 cites W2138390741 @default.
- W3037940256 cites W2145150141 @default.
- W3037940256 cites W2151789361 @default.
- W3037940256 cites W2152737552 @default.
- W3037940256 cites W2164922088 @default.
- W3037940256 cites W2167942009 @default.
- W3037940256 cites W2168481287 @default.
- W3037940256 cites W2171328556 @default.
- W3037940256 cites W2199324259 @default.
- W3037940256 cites W2254700286 @default.
- W3037940256 cites W2295652535 @default.
- W3037940256 cites W2319744757 @default.
- W3037940256 cites W2320635188 @default.
- W3037940256 cites W2329825826 @default.
- W3037940256 cites W2337882641 @default.
- W3037940256 cites W2399230052 @default.
- W3037940256 cites W2404344098 @default.
- W3037940256 cites W2416201384 @default.
- W3037940256 cites W2460334402 @default.
- W3037940256 cites W2511744717 @default.
- W3037940256 cites W2551085581 @default.
- W3037940256 cites W2562857190 @default.
- W3037940256 cites W2586568558 @default.
- W3037940256 cites W2591407779 @default.
- W3037940256 cites W2592003306 @default.
- W3037940256 cites W2750173042 @default.
- W3037940256 cites W2762352971 @default.
- W3037940256 cites W2766758159 @default.
- W3037940256 cites W2768934429 @default.
- W3037940256 cites W2774712224 @default.
- W3037940256 cites W2788734929 @default.
- W3037940256 cites W2803464864 @default.
- W3037940256 cites W2804244046 @default.
- W3037940256 cites W2804982697 @default.
- W3037940256 cites W2886315657 @default.
- W3037940256 cites W2889646458 @default.
- W3037940256 cites W2891922050 @default.