Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037959615> ?p ?o ?g. }
- W3037959615 abstract "Abstract Ph + acute lymphoblastic leukemia (ALL) is characterized by the expression of an oncogenic fusion kinase termed BCR-ABL1. Here, we show that interleukin 7 receptor (IL7R) interacts with the chemokine receptor CXCR4 to recruit BCR-ABL1 and JAK kinases in close proximity. Treatment with BCR-ABL1 kinase inhibitors results in elevated expression of IL7R which enables the survival of transformed cells when IL7 was added together with the kinase inhibitors. Importantly, treatment with anti-IL7R antibodies prevents leukemia development in xenotransplantation models using patient-derived Ph + ALL cells. Our results suggest that the association between IL7R and CXCR4 serves as molecular platform for BCR-ABL1-induced transformation and development of Ph + ALL. Targeting this platform with anti-IL7R antibody eliminates Ph + ALL cells including those with resistance to commonly used ABL1 kinase inhibitors. Thus, anti-IL7R antibodies may provide alternative treatment options for ALL in general and may suppress incurable drug-resistant leukemia forms." @default.
- W3037959615 created "2020-07-02" @default.
- W3037959615 creator A5004597675 @default.
- W3037959615 creator A5011513433 @default.
- W3037959615 creator A5012603847 @default.
- W3037959615 creator A5018476161 @default.
- W3037959615 creator A5020812442 @default.
- W3037959615 creator A5039478360 @default.
- W3037959615 creator A5039583258 @default.
- W3037959615 creator A5049679155 @default.
- W3037959615 creator A5050087793 @default.
- W3037959615 creator A5054075906 @default.
- W3037959615 creator A5055420202 @default.
- W3037959615 creator A5057658323 @default.
- W3037959615 creator A5065051699 @default.
- W3037959615 creator A5066866382 @default.
- W3037959615 creator A5067558273 @default.
- W3037959615 creator A5070751228 @default.
- W3037959615 creator A5078855077 @default.
- W3037959615 creator A5078953949 @default.
- W3037959615 creator A5079690916 @default.
- W3037959615 creator A5080704534 @default.
- W3037959615 creator A5088601426 @default.
- W3037959615 date "2020-06-24" @default.
- W3037959615 modified "2023-10-14" @default.
- W3037959615 title "Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia" @default.
- W3037959615 cites W1509163238 @default.
- W3037959615 cites W1521820669 @default.
- W3037959615 cites W1901988103 @default.
- W3037959615 cites W1917578864 @default.
- W3037959615 cites W1964250079 @default.
- W3037959615 cites W1973094248 @default.
- W3037959615 cites W1979026253 @default.
- W3037959615 cites W1994041743 @default.
- W3037959615 cites W1997569631 @default.
- W3037959615 cites W2020541351 @default.
- W3037959615 cites W2028104399 @default.
- W3037959615 cites W2037896121 @default.
- W3037959615 cites W2047597898 @default.
- W3037959615 cites W2049027605 @default.
- W3037959615 cites W2050651394 @default.
- W3037959615 cites W2055600079 @default.
- W3037959615 cites W2057781689 @default.
- W3037959615 cites W2058971169 @default.
- W3037959615 cites W2067347835 @default.
- W3037959615 cites W2080181628 @default.
- W3037959615 cites W2085540799 @default.
- W3037959615 cites W2088795009 @default.
- W3037959615 cites W2092606584 @default.
- W3037959615 cites W2096632716 @default.
- W3037959615 cites W2100386815 @default.
- W3037959615 cites W2103420336 @default.
- W3037959615 cites W2107268345 @default.
- W3037959615 cites W2115667429 @default.
- W3037959615 cites W2119967034 @default.
- W3037959615 cites W2124324819 @default.
- W3037959615 cites W2127226843 @default.
- W3037959615 cites W2128645075 @default.
- W3037959615 cites W2129141528 @default.
- W3037959615 cites W2130410032 @default.
- W3037959615 cites W2141231618 @default.
- W3037959615 cites W2141648366 @default.
- W3037959615 cites W2148202982 @default.
- W3037959615 cites W2159863363 @default.
- W3037959615 cites W2162653211 @default.
- W3037959615 cites W2166654361 @default.
- W3037959615 cites W2167341854 @default.
- W3037959615 cites W2178122647 @default.
- W3037959615 cites W2178214143 @default.
- W3037959615 cites W2243988080 @default.
- W3037959615 cites W2272492597 @default.
- W3037959615 cites W2300592511 @default.
- W3037959615 cites W2316240155 @default.
- W3037959615 cites W2316942563 @default.
- W3037959615 cites W2419699846 @default.
- W3037959615 cites W2440705721 @default.
- W3037959615 cites W2526338590 @default.
- W3037959615 cites W2581891628 @default.
- W3037959615 cites W2610328326 @default.
- W3037959615 cites W2611160678 @default.
- W3037959615 cites W2889246099 @default.
- W3037959615 cites W2889395887 @default.
- W3037959615 cites W2890368148 @default.
- W3037959615 cites W2895925712 @default.
- W3037959615 cites W2903563962 @default.
- W3037959615 cites W2969354818 @default.
- W3037959615 doi "https://doi.org/10.1038/s41467-020-16927-w" @default.
- W3037959615 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7314847" @default.
- W3037959615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32581241" @default.
- W3037959615 hasPublicationYear "2020" @default.
- W3037959615 type Work @default.
- W3037959615 sameAs 3037959615 @default.
- W3037959615 citedByCount "12" @default.
- W3037959615 countsByYear W30379596152020 @default.
- W3037959615 countsByYear W30379596152021 @default.
- W3037959615 countsByYear W30379596152022 @default.
- W3037959615 countsByYear W30379596152023 @default.
- W3037959615 crossrefType "journal-article" @default.
- W3037959615 hasAuthorship W3037959615A5004597675 @default.
- W3037959615 hasAuthorship W3037959615A5011513433 @default.