FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037969457> ?p ?o ?g. }

• W3037969457 endingPage "2138" @default.
• W3037969457 startingPage "2119" @default.
• W3037969457 abstract "Summary Plant responses to coincident nutrient deficiencies cannot be predicted from the responses to individual deficiencies. Although copper (Cu) and iron (Fe) are essential micronutrients for plant growth that are often and concurrently limited in soils, the combinatorial response to Cu‐Fe deficiency remains elusive. In the present study, we characterised the responses of Arabidopsis thaliana plants deprived of Cu, Fe or both (‐Cu‐Fe) at the level of plant development, mineral composition, and reconfiguration of transcriptomes, proteomes and metabolomes. Compared to single deficiencies, simultaneous ‐Cu‐Fe leads to a distinct pattern in leaf physiology and microelement concentration characterised by lowered protein content and enhanced manganese and zinc levels. Conditional networking analysis of molecular changes indicates that biological processes also display different co‐expression patterns among single and double deficiencies. Indeed, the interaction between Cu and Fe deficiencies causes distinct expression profiles for 15% of all biomolecules, leading to specific enhancement of general stress responses and protein homeostasis mechanisms, at the same time as severely arresting photosynthesis. Accordingly, central carbon metabolites, in particular photosynthates, decrease especially under ‐Cu‐Fe conditions, whereas the pool of free amino acids increases. Further meta‐analysis of transcriptomes and proteomes corroborated that protein biosynthesis and folding capacity were readjusted during the combinatorial response and unveiled important rearrangements in the metabolism of organic acids. Consequently, our results demonstrate that the response to ‐Cu‐Fe imposes a distinct reconfiguration of large sets of molecules, not triggered by single deficiencies, resulting into a switch from autotrophy to heterotrophy and involving organic acids such as fumaric acid as central mediators of the response." @default.
• W3037969457 created "2020-07-02" @default.
• W3037969457 creator A5027094672 @default.
• W3037969457 creator A5044837990 @default.
• W3037969457 creator A5068664764 @default.
• W3037969457 creator A5087762478 @default.
• W3037969457 date "2020-07-18" @default.
• W3037969457 modified "2023-10-18" @default.
• W3037969457 title "Systems biology of responses to simultaneous copper and iron deficiency in Arabidopsis" @default.
• W3037969457 cites W113911865 @default.
• W3037969457 cites W145473912 @default.
• W3037969457 cites W1514552235 @default.
• W3037969457 cites W1552044579 @default.
• W3037969457 cites W1570666299 @default.
• W3037969457 cites W1686396958 @default.
• W3037969457 cites W1845358664 @default.
• W3037969457 cites W1944729816 @default.
• W3037969457 cites W1946916868 @default.
• W3037969457 cites W1967826096 @default.
• W3037969457 cites W1969353942 @default.
• W3037969457 cites W1973673322 @default.
• W3037969457 cites W1975334905 @default.
• W3037969457 cites W1984442503 @default.
• W3037969457 cites W1990492842 @default.
• W3037969457 cites W1999364433 @default.
• W3037969457 cites W2006303829 @default.
• W3037969457 cites W2006317824 @default.
• W3037969457 cites W2011764011 @default.
• W3037969457 cites W2016664491 @default.
• W3037969457 cites W2021912641 @default.
• W3037969457 cites W2023010129 @default.
• W3037969457 cites W2024058598 @default.
• W3037969457 cites W2026976781 @default.
• W3037969457 cites W2028770228 @default.
• W3037969457 cites W2029795722 @default.
• W3037969457 cites W2030965575 @default.
• W3037969457 cites W2031819009 @default.
• W3037969457 cites W2036321220 @default.
• W3037969457 cites W2047098048 @default.
• W3037969457 cites W2047940964 @default.
• W3037969457 cites W2054302409 @default.
• W3037969457 cites W2056498136 @default.
• W3037969457 cites W2064485022 @default.
• W3037969457 cites W2066163038 @default.
• W3037969457 cites W2080752012 @default.
• W3037969457 cites W2086612083 @default.
• W3037969457 cites W2087276505 @default.
• W3037969457 cites W2089124229 @default.
• W3037969457 cites W2092003845 @default.
• W3037969457 cites W2094061373 @default.
• W3037969457 cites W2100305481 @default.
• W3037969457 cites W2106077509 @default.
• W3037969457 cites W2106385442 @default.
• W3037969457 cites W2110065044 @default.
• W3037969457 cites W2111199888 @default.
• W3037969457 cites W2112092738 @default.
• W3037969457 cites W2115398984 @default.
• W3037969457 cites W2117527407 @default.
• W3037969457 cites W2118159036 @default.
• W3037969457 cites W2118661329 @default.
• W3037969457 cites W2122640833 @default.
• W3037969457 cites W2124083986 @default.
• W3037969457 cites W2128171377 @default.
• W3037969457 cites W2128642008 @default.
• W3037969457 cites W2131271579 @default.
• W3037969457 cites W2134375320 @default.
• W3037969457 cites W2138474004 @default.
• W3037969457 cites W2140729960 @default.
• W3037969457 cites W2140853036 @default.
• W3037969457 cites W2141458291 @default.
• W3037969457 cites W2143804344 @default.
• W3037969457 cites W2144362235 @default.
• W3037969457 cites W2145704416 @default.
• W3037969457 cites W2147636237 @default.
• W3037969457 cites W2148951714 @default.
• W3037969457 cites W2151346683 @default.
• W3037969457 cites W2152216168 @default.
• W3037969457 cites W2159675211 @default.
• W3037969457 cites W2161586263 @default.
• W3037969457 cites W2162314707 @default.
• W3037969457 cites W2162731200 @default.
• W3037969457 cites W2168617775 @default.
• W3037969457 cites W2170776626 @default.
• W3037969457 cites W2171438903 @default.
• W3037969457 cites W2172281517 @default.
• W3037969457 cites W2405752231 @default.
• W3037969457 cites W2463195069 @default.
• W3037969457 cites W2491980619 @default.
• W3037969457 cites W2531483935 @default.
• W3037969457 cites W2588433599 @default.
• W3037969457 cites W268148843 @default.
• W3037969457 cites W2767422184 @default.
• W3037969457 cites W2900661284 @default.
• W3037969457 cites W2939360305 @default.
• W3037969457 cites W3005472031 @default.
• W3037969457 cites W4211239380 @default.
• W3037969457 cites W4246054248 @default.
• W3037969457 cites W4246757476 @default.

• next