Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037973995> ?p ?o ?g. }
- W3037973995 abstract "B lymphocytes play a critical role in humoral immunity. Abnormal B cell development and function cause a variety of hematological malignancies such as myeloma, B cell lymphoma, and leukemia. Histone deacetylase 6 (HDAC6) inhibitors alone or in combination with other drugs have shown efficacy in several hematological malignancies, including those resistant to targeted therapies. Mechanistically, HDAC6 inhibitors promote malignant tumor cell apoptosis by inhibiting protein degradation, reinvigorating anti-tumor immunity, and inhibiting cell survival signaling pathways. Due to their specificity, HDAC6 inhibitors represent a very promising and feasible new development pipeline for high-efficacy drugs with limited side effects. This article reviews recent progress in the mechanisms of action of HDAC6 inhibitors for the treatment of B cell-associated hematological malignancies, such as multiple myeloma and B cell non-Hodgkin lymphoma, which are often resistant to targeted therapies." @default.
- W3037973995 created "2020-07-02" @default.
- W3037973995 creator A5022169204 @default.
- W3037973995 creator A5025872255 @default.
- W3037973995 creator A5058127847 @default.
- W3037973995 date "2020-06-26" @default.
- W3037973995 modified "2023-09-27" @default.
- W3037973995 title "Histone Deacetylase 6 as a Therapeutic Target in B cell-associated Hematological Malignancies" @default.
- W3037973995 cites W1522396134 @default.
- W3037973995 cites W1581327352 @default.
- W3037973995 cites W1869200070 @default.
- W3037973995 cites W1890948742 @default.
- W3037973995 cites W1955732360 @default.
- W3037973995 cites W1966268694 @default.
- W3037973995 cites W1967100876 @default.
- W3037973995 cites W1977146148 @default.
- W3037973995 cites W1979832500 @default.
- W3037973995 cites W1980783927 @default.
- W3037973995 cites W1997166178 @default.
- W3037973995 cites W1998499089 @default.
- W3037973995 cites W2008815830 @default.
- W3037973995 cites W2022580424 @default.
- W3037973995 cites W2040758136 @default.
- W3037973995 cites W2054688293 @default.
- W3037973995 cites W2063264144 @default.
- W3037973995 cites W2064959533 @default.
- W3037973995 cites W2071380029 @default.
- W3037973995 cites W2072059006 @default.
- W3037973995 cites W2084156359 @default.
- W3037973995 cites W2086802631 @default.
- W3037973995 cites W2090926709 @default.
- W3037973995 cites W2090940271 @default.
- W3037973995 cites W2095026025 @default.
- W3037973995 cites W2095788199 @default.
- W3037973995 cites W2101127235 @default.
- W3037973995 cites W2107583204 @default.
- W3037973995 cites W2112004353 @default.
- W3037973995 cites W2113158650 @default.
- W3037973995 cites W2136155557 @default.
- W3037973995 cites W2143444597 @default.
- W3037973995 cites W2149555430 @default.
- W3037973995 cites W2162787110 @default.
- W3037973995 cites W2165638033 @default.
- W3037973995 cites W2166427186 @default.
- W3037973995 cites W2170793132 @default.
- W3037973995 cites W2171826160 @default.
- W3037973995 cites W2181906789 @default.
- W3037973995 cites W2226504859 @default.
- W3037973995 cites W2280935809 @default.
- W3037973995 cites W2302499530 @default.
- W3037973995 cites W2338572103 @default.
- W3037973995 cites W2343095836 @default.
- W3037973995 cites W2415330588 @default.
- W3037973995 cites W2520638688 @default.
- W3037973995 cites W2542880571 @default.
- W3037973995 cites W2559084827 @default.
- W3037973995 cites W2569372699 @default.
- W3037973995 cites W2593000332 @default.
- W3037973995 cites W2593366496 @default.
- W3037973995 cites W2767683410 @default.
- W3037973995 cites W2773548225 @default.
- W3037973995 cites W2786814228 @default.
- W3037973995 cites W2790226786 @default.
- W3037973995 cites W2790574591 @default.
- W3037973995 cites W2791113648 @default.
- W3037973995 cites W2791674076 @default.
- W3037973995 cites W2800178678 @default.
- W3037973995 cites W2801084326 @default.
- W3037973995 cites W2806780878 @default.
- W3037973995 cites W2890263735 @default.
- W3037973995 cites W2900890595 @default.
- W3037973995 cites W2901299070 @default.
- W3037973995 cites W2901300056 @default.
- W3037973995 cites W2901494388 @default.
- W3037973995 cites W2905930033 @default.
- W3037973995 cites W2907309697 @default.
- W3037973995 cites W2909231646 @default.
- W3037973995 cites W2909778982 @default.
- W3037973995 cites W2913405210 @default.
- W3037973995 cites W2914383086 @default.
- W3037973995 cites W2932314044 @default.
- W3037973995 cites W2937191569 @default.
- W3037973995 cites W2942170171 @default.
- W3037973995 cites W2979640690 @default.
- W3037973995 cites W2981577500 @default.
- W3037973995 cites W2996285733 @default.
- W3037973995 cites W3015225361 @default.
- W3037973995 cites W3016105251 @default.
- W3037973995 cites W3025291253 @default.
- W3037973995 cites W4238401889 @default.
- W3037973995 doi "https://doi.org/10.3389/fphar.2020.00971" @default.
- W3037973995 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7333221" @default.
- W3037973995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32676030" @default.
- W3037973995 hasPublicationYear "2020" @default.
- W3037973995 type Work @default.
- W3037973995 sameAs 3037973995 @default.
- W3037973995 citedByCount "7" @default.
- W3037973995 countsByYear W30379739952021 @default.
- W3037973995 countsByYear W30379739952022 @default.
- W3037973995 countsByYear W30379739952023 @default.