Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037975981> ?p ?o ?g. }
- W3037975981 endingPage "301" @default.
- W3037975981 startingPage "259" @default.
- W3037975981 abstract "Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a common chronic pain condition with major impact on quality of life. Examples include trigeminal neuralgia, painful polyneuropathy, postherpetic neuralgia, and central poststroke pain. Most patients complain of an ongoing or intermittent spontaneous pain of, for example, burning, pricking, squeezing quality, which may be accompanied by evoked pain, particular to light touch and cold. Ectopic activity in, for example, nerve-end neuroma, compressed nerves or nerve roots, dorsal root ganglia, and the thalamus may in different conditions underlie the spontaneous pain. Evoked pain may spread to neighboring areas, and the underlying pathophysiology involves peripheral and central sensitization. Maladaptive structural changes and a number of cell-cell interactions and molecular signaling underlie the sensitization of nociceptive pathways. These include alteration in ion channels, activation of immune cells, glial-derived mediators, and epigenetic regulation. The major classes of therapeutics include drugs acting on α 2 δ subunits of calcium channels, sodium channels, and descending modulatory inhibitory pathways." @default.
- W3037975981 created "2020-07-02" @default.
- W3037975981 creator A5041298056 @default.
- W3037975981 creator A5047938981 @default.
- W3037975981 creator A5066094707 @default.
- W3037975981 date "2021-01-01" @default.
- W3037975981 modified "2023-10-18" @default.
- W3037975981 title "Neuropathic Pain: From Mechanisms to Treatment" @default.
- W3037975981 cites W1012433823 @default.
- W3037975981 cites W1582090951 @default.
- W3037975981 cites W1583435661 @default.
- W3037975981 cites W1617368976 @default.
- W3037975981 cites W1625407287 @default.
- W3037975981 cites W1679569903 @default.
- W3037975981 cites W1843071464 @default.
- W3037975981 cites W1879868943 @default.
- W3037975981 cites W1926546914 @default.
- W3037975981 cites W1937769321 @default.
- W3037975981 cites W1944937124 @default.
- W3037975981 cites W1964974123 @default.
- W3037975981 cites W1965510289 @default.
- W3037975981 cites W1966033777 @default.
- W3037975981 cites W1966259066 @default.
- W3037975981 cites W1966544805 @default.
- W3037975981 cites W1969751124 @default.
- W3037975981 cites W1969856080 @default.
- W3037975981 cites W1971005199 @default.
- W3037975981 cites W1971646618 @default.
- W3037975981 cites W1972216962 @default.
- W3037975981 cites W1972459506 @default.
- W3037975981 cites W1972947543 @default.
- W3037975981 cites W1973394048 @default.
- W3037975981 cites W1973903947 @default.
- W3037975981 cites W1974162493 @default.
- W3037975981 cites W1974213802 @default.
- W3037975981 cites W1974542461 @default.
- W3037975981 cites W1975237575 @default.
- W3037975981 cites W1975875514 @default.
- W3037975981 cites W1977087698 @default.
- W3037975981 cites W1977322234 @default.
- W3037975981 cites W1977665632 @default.
- W3037975981 cites W1978269241 @default.
- W3037975981 cites W1978608725 @default.
- W3037975981 cites W1979001185 @default.
- W3037975981 cites W1979137100 @default.
- W3037975981 cites W1979482847 @default.
- W3037975981 cites W1980144587 @default.
- W3037975981 cites W1980679598 @default.
- W3037975981 cites W1981003526 @default.
- W3037975981 cites W1981047340 @default.
- W3037975981 cites W1981692109 @default.
- W3037975981 cites W1981915431 @default.
- W3037975981 cites W1981920430 @default.
- W3037975981 cites W1982281847 @default.
- W3037975981 cites W1982415930 @default.
- W3037975981 cites W1984144008 @default.
- W3037975981 cites W1986350746 @default.
- W3037975981 cites W1987736353 @default.
- W3037975981 cites W1988059060 @default.
- W3037975981 cites W1988923525 @default.
- W3037975981 cites W1989149115 @default.
- W3037975981 cites W1989564891 @default.
- W3037975981 cites W1990044083 @default.
- W3037975981 cites W1991283674 @default.
- W3037975981 cites W1991550485 @default.
- W3037975981 cites W1991603736 @default.
- W3037975981 cites W1992768230 @default.
- W3037975981 cites W1993479338 @default.
- W3037975981 cites W1993672401 @default.
- W3037975981 cites W1994618304 @default.
- W3037975981 cites W1996108985 @default.
- W3037975981 cites W1997333327 @default.
- W3037975981 cites W1997890272 @default.
- W3037975981 cites W1998233283 @default.
- W3037975981 cites W1998309390 @default.
- W3037975981 cites W1998477586 @default.
- W3037975981 cites W1998724065 @default.
- W3037975981 cites W2000364468 @default.
- W3037975981 cites W2000530619 @default.
- W3037975981 cites W2003542915 @default.
- W3037975981 cites W2003619055 @default.
- W3037975981 cites W2003630500 @default.
- W3037975981 cites W2003748590 @default.
- W3037975981 cites W2004284432 @default.
- W3037975981 cites W2004320737 @default.
- W3037975981 cites W2004683867 @default.
- W3037975981 cites W2005007162 @default.
- W3037975981 cites W2005698465 @default.
- W3037975981 cites W2006393871 @default.
- W3037975981 cites W2006669505 @default.
- W3037975981 cites W2007105174 @default.
- W3037975981 cites W2007592542 @default.
- W3037975981 cites W2007634429 @default.
- W3037975981 cites W2007684439 @default.
- W3037975981 cites W2008733031 @default.
- W3037975981 cites W2008902622 @default.
- W3037975981 cites W2008922193 @default.
- W3037975981 cites W2009058113 @default.