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- W3037976980 abstract "Objective: In this paper, we investigated by nuclear magnetic resonance (NMR) erythrocyte membrane permeability in patients with cardiovascular pathologies with different pathogenic mecanisms:such as arterial hyperthension,atherosclerosis and chronic ischemic cardiomypathy. Design and method: NMR investigations were done on erythrocyte membrane from patients with cardiovascular pathologies versus controls using the following tests: T2a – the intraerythrocyte water protons relaxation time; - the red cell water protons lifetime; EMPW – the erythrocyte membrane permeability to water; Esed – the activation energy of the intraerythrocyte proton relaxation processes; E - the activation energy of the water transport through the erythrocyte membrane. NMR measurements were performed with an AREMI pulse spectrometer at a frequency of 25 MHz using the standard sequence CARR-PURCELL-MEIBOOM-GILL with a 1-msec interval between pulses. Results: Our data pointed out the highest red cell water proton lifetime values, characterizing mostly women patients with CIC (chronic ischemic cardiopathy) and atherosclerosis, reflect the diminished intracellular metabolism. The erythrocyte membrane permeability values higher than normal are experienced by the HTA men and, in the onset phase, by both sexes, then this parameter decreases as a function of disease stage and severity. The lower values of activation energy of water transport through the erythrocyte membrane, associated with the higher intraerythrocyte water protons relaxation time values are characteristic for old atherosclerotic men. Conclusions: The nuclear magnetic resonance is a useful tool in characterization of some biophysics aspects occurring in erythrocites different cardiovascular diseases and in onset disease prediction." @default.
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- W3037976980 date "2015-06-01" @default.
- W3037976980 modified "2023-10-14" @default.
- W3037976980 title "PP.42.18" @default.
- W3037976980 doi "https://doi.org/10.1097/01.hjh.0000469011.48632.11" @default.
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