Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037977816> ?p ?o ?g. }
- W3037977816 abstract "Abstract Atherosclerosis is crucially fueled by inflammatory pathways including pattern recognition receptor (PRR)-related signaling of the innate immune system. Currently, the impact of the cytoplasmic PRRs nucleotide-binding oligomerization domain-containing protein (NOD) 1 and 2 is incompletely characterized. We, therefore, generated Nod1 / Nod2 double knockout mice on a low-density lipoprotein receptor ( Ldlr )-deficient background (= Ldlr −/− Nod1/2 −/− ) which were subsequently analyzed regarding experimental atherosclerosis, lipid metabolism, insulin resistance and gut microbiota composition. Compared to Ldlr −/− mice, Ldlr −/− Nod1/2 −/− mice showed reduced plasma lipids and increased hepatic expression of the scavenger receptor LDL receptor-related protein 1 after feeding a high-fat diet for 12 weeks. Furthermore, intestinal cholesterol and its bacterial degradation product coprostanol were elevated in Ldlr −/− Nod1/2 −/− mice, correlating with the increased abundance of Eubacterium coprostanoligenes as assessed by 3rd generation sequencing of the gut microbiota. Atherosclerotic plaques of Ldlr −/− Nod1/2 −/− mice exhibited less lipid deposition and macrophage accumulation. Moreover, macrophages from Ldlr −/− Nod1/2 −/− mice showed higher expression of the cholesterol efflux transporters Abca1 and Abcg1 and accordingly reduced foam cell formation. Deficiency of Nod1 and Nod2 led to reduced plaque lipid deposition and inflammatory cell infiltration in atherosclerotic plaques. This might be explained by diminished plasma lipid levels and foam cell formation due to altered expression of key regulators of the hepatic cholesterol pathway as well as differential intestinal cholesterol metabolism and microbiota composition." @default.
- W3037977816 created "2020-07-02" @default.
- W3037977816 creator A5003370853 @default.
- W3037977816 creator A5006375444 @default.
- W3037977816 creator A5007653727 @default.
- W3037977816 creator A5008038627 @default.
- W3037977816 creator A5038005354 @default.
- W3037977816 creator A5039189185 @default.
- W3037977816 creator A5039216223 @default.
- W3037977816 creator A5045810843 @default.
- W3037977816 creator A5060202571 @default.
- W3037977816 creator A5061584676 @default.
- W3037977816 creator A5066826351 @default.
- W3037977816 creator A5072039911 @default.
- W3037977816 creator A5072531556 @default.
- W3037977816 creator A5074006232 @default.
- W3037977816 date "2020-06-25" @default.
- W3037977816 modified "2023-10-15" @default.
- W3037977816 title "Deficiency of Nucleotide-binding oligomerization domain-containing proteins (NOD) 1 and 2 reduces atherosclerosis" @default.
- W3037977816 cites W1827132410 @default.
- W3037977816 cites W1944504373 @default.
- W3037977816 cites W1983871162 @default.
- W3037977816 cites W2001166572 @default.
- W3037977816 cites W2018788678 @default.
- W3037977816 cites W2031502524 @default.
- W3037977816 cites W2045495850 @default.
- W3037977816 cites W2054761912 @default.
- W3037977816 cites W2070895425 @default.
- W3037977816 cites W2105924650 @default.
- W3037977816 cites W2106165477 @default.
- W3037977816 cites W2136736147 @default.
- W3037977816 cites W2145153359 @default.
- W3037977816 cites W2150795824 @default.
- W3037977816 cites W2157668393 @default.
- W3037977816 cites W2159475512 @default.
- W3037977816 cites W2161028712 @default.
- W3037977816 cites W2161332823 @default.
- W3037977816 cites W2165857119 @default.
- W3037977816 cites W2190717301 @default.
- W3037977816 cites W2260950355 @default.
- W3037977816 cites W2498215202 @default.
- W3037977816 cites W2528373715 @default.
- W3037977816 cites W2560194208 @default.
- W3037977816 cites W2585723148 @default.
- W3037977816 cites W2606443041 @default.
- W3037977816 cites W2748400555 @default.
- W3037977816 cites W2775794168 @default.
- W3037977816 cites W2898998405 @default.
- W3037977816 cites W2903041139 @default.
- W3037977816 cites W2964452372 @default.
- W3037977816 cites W2970130570 @default.
- W3037977816 cites W4211237344 @default.
- W3037977816 doi "https://doi.org/10.1007/s00395-020-0806-2" @default.
- W3037977816 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7316681" @default.
- W3037977816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32588196" @default.
- W3037977816 hasPublicationYear "2020" @default.
- W3037977816 type Work @default.
- W3037977816 sameAs 3037977816 @default.
- W3037977816 citedByCount "17" @default.
- W3037977816 countsByYear W30379778162020 @default.
- W3037977816 countsByYear W30379778162021 @default.
- W3037977816 countsByYear W30379778162022 @default.
- W3037977816 countsByYear W30379778162023 @default.
- W3037977816 crossrefType "journal-article" @default.
- W3037977816 hasAuthorship W3037977816A5003370853 @default.
- W3037977816 hasAuthorship W3037977816A5006375444 @default.
- W3037977816 hasAuthorship W3037977816A5007653727 @default.
- W3037977816 hasAuthorship W3037977816A5008038627 @default.
- W3037977816 hasAuthorship W3037977816A5038005354 @default.
- W3037977816 hasAuthorship W3037977816A5039189185 @default.
- W3037977816 hasAuthorship W3037977816A5039216223 @default.
- W3037977816 hasAuthorship W3037977816A5045810843 @default.
- W3037977816 hasAuthorship W3037977816A5060202571 @default.
- W3037977816 hasAuthorship W3037977816A5061584676 @default.
- W3037977816 hasAuthorship W3037977816A5066826351 @default.
- W3037977816 hasAuthorship W3037977816A5072039911 @default.
- W3037977816 hasAuthorship W3037977816A5072531556 @default.
- W3037977816 hasAuthorship W3037977816A5074006232 @default.
- W3037977816 hasBestOaLocation W30379778161 @default.
- W3037977816 hasConcept C104317684 @default.
- W3037977816 hasConcept C111289621 @default.
- W3037977816 hasConcept C126322002 @default.
- W3037977816 hasConcept C134018914 @default.
- W3037977816 hasConcept C136449434 @default.
- W3037977816 hasConcept C149011108 @default.
- W3037977816 hasConcept C170493617 @default.
- W3037977816 hasConcept C185592680 @default.
- W3037977816 hasConcept C2777209026 @default.
- W3037977816 hasConcept C2777291061 @default.
- W3037977816 hasConcept C2777704780 @default.
- W3037977816 hasConcept C2777895019 @default.
- W3037977816 hasConcept C2778163477 @default.
- W3037977816 hasConcept C2780072125 @default.
- W3037977816 hasConcept C41443022 @default.
- W3037977816 hasConcept C43554185 @default.
- W3037977816 hasConcept C55493867 @default.
- W3037977816 hasConcept C555293320 @default.
- W3037977816 hasConcept C55851684 @default.
- W3037977816 hasConcept C71924100 @default.
- W3037977816 hasConcept C7573103 @default.