FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037979376> ?p ?o ?g. }

• W3037979376 endingPage "1785" @default.
• W3037979376 startingPage "1774" @default.
• W3037979376 abstract "Abstract Objective Posttraumatic epilepsy (PTE) is defined as recurrent and unprovoked seizures occurring >1 week after traumatic brain injury (TBI). Animal studies of PTE are lengthy and expensive. In this study, we developed a cost‐effective PTE animal model using zebrafish to bridge the gap between in vitro studies and low‐throughput animal studies. Methods We used two different sets of parameters (G1 and G2) to induce closed‐head TBI in adult zebrafish using pulsed high‐intensity focused ultrasound. Injured fish and naive controls were evaluated for behavioral deficits and spontaneous behavioral seizure activity up to 21 days postinjury (DPI). We also assessed behavioral seizure susceptibility to a subconvulsive dose of pentylenetetrazole (PTZ; 2.5 mmol·L –1 ) and recorded electrophysiological signals to confirm seizure activity up to 40 DPI. In addition, we investigated injury‐related changes in the blood‐brain barrier and expression levels of various proteins altered in rodent and human TBI. Results The G2 parameters resulted in a more severe TBI, with a mortality rate of 25%, as well as motor dysfunction and heightened anxiety persisting at 21 DPI. One hundred percent of the G2 group showed spontaneous myocloniclike behavior, and 80% demonstrated tonic‐clonic–like behavioral seizures by 21 DPI. Such activities were not detected in the naive group. After the application of 2.5 mmol·L –1 PTZ, 100% of injured zebrafish had cloniclike seizures at 21 DPI, versus 30% of the naive group. We also demonstrated electrographic seizure activity at 40 DPI, which was not detected in the naive controls. Lastly, we observed acute blood‐brain barrier dysfunction and increased levels of HMGB1 and ratios of phosphorylated/total Akt and tau through 21 DPI. Significance Together, the results indicate that severe TBI in the adult zebrafish leads to similar behavioral and physiological changes to those of more traditional models, including the development of PTE, and suggest this may be a useful model that can accelerate research in TBI/PTE." @default.
• W3037979376 created "2020-07-02" @default.
• W3037979376 creator A5032158404 @default.
• W3037979376 creator A5033932679 @default.
• W3037979376 creator A5035253208 @default.
• W3037979376 creator A5046918248 @default.
• W3037979376 creator A5055456256 @default.
• W3037979376 date "2020-06-27" @default.
• W3037979376 modified "2023-09-25" @default.
• W3037979376 title "Zebrafish model of posttraumatic epilepsy" @default.
• W3037979376 cites W1557124033 @default.
• W3037979376 cites W1566569411 @default.
• W3037979376 cites W1900267874 @default.
• W3037979376 cites W1971775352 @default.
• W3037979376 cites W1983635597 @default.
• W3037979376 cites W1989822657 @default.
• W3037979376 cites W1997435185 @default.
• W3037979376 cites W1998203489 @default.
• W3037979376 cites W1999934730 @default.
• W3037979376 cites W2000180742 @default.
• W3037979376 cites W2030352621 @default.
• W3037979376 cites W2031819252 @default.
• W3037979376 cites W2035565598 @default.
• W3037979376 cites W2045839175 @default.
• W3037979376 cites W2048137511 @default.
• W3037979376 cites W2051600991 @default.
• W3037979376 cites W2055452454 @default.
• W3037979376 cites W2068816019 @default.
• W3037979376 cites W2071581284 @default.
• W3037979376 cites W2077812756 @default.
• W3037979376 cites W2079121315 @default.
• W3037979376 cites W2086151095 @default.
• W3037979376 cites W2087982685 @default.
• W3037979376 cites W2096019298 @default.
• W3037979376 cites W2107550955 @default.
• W3037979376 cites W2151136069 @default.
• W3037979376 cites W2166939339 @default.
• W3037979376 cites W2297117323 @default.
• W3037979376 cites W2308053466 @default.
• W3037979376 cites W2310163083 @default.
• W3037979376 cites W2324558767 @default.
• W3037979376 cites W2412978786 @default.
• W3037979376 cites W2477083732 @default.
• W3037979376 cites W2523621893 @default.
• W3037979376 cites W2589877117 @default.
• W3037979376 cites W2620742343 @default.
• W3037979376 cites W2745047077 @default.
• W3037979376 cites W2783940554 @default.
• W3037979376 cites W2901924768 @default.
• W3037979376 cites W2907636734 @default.
• W3037979376 cites W2909985059 @default.
• W3037979376 cites W2913449734 @default.
• W3037979376 cites W2939098842 @default.
• W3037979376 cites W2944969368 @default.
• W3037979376 cites W2967072814 @default.
• W3037979376 cites W2982395477 @default.
• W3037979376 cites W565659846 @default.
• W3037979376 doi "https://doi.org/10.1111/epi.16589" @default.
• W3037979376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32592416" @default.
• W3037979376 hasPublicationYear "2020" @default.
• W3037979376 type Work @default.
• W3037979376 sameAs 3037979376 @default.
• W3037979376 citedByCount "19" @default.
• W3037979376 countsByYear W30379793762020 @default.
• W3037979376 countsByYear W30379793762021 @default.
• W3037979376 countsByYear W30379793762022 @default.
• W3037979376 countsByYear W30379793762023 @default.
• W3037979376 crossrefType "journal-article" @default.
• W3037979376 hasAuthorship W3037979376A5032158404 @default.
• W3037979376 hasAuthorship W3037979376A5033932679 @default.
• W3037979376 hasAuthorship W3037979376A5035253208 @default.
• W3037979376 hasAuthorship W3037979376A5046918248 @default.
• W3037979376 hasAuthorship W3037979376A5055456256 @default.
• W3037979376 hasConcept C104317684 @default.
• W3037979376 hasConcept C118552586 @default.
• W3037979376 hasConcept C126322002 @default.
• W3037979376 hasConcept C15744967 @default.
• W3037979376 hasConcept C169760540 @default.
• W3037979376 hasConcept C2776878037 @default.
• W3037979376 hasConcept C2778117688 @default.
• W3037979376 hasConcept C2778186239 @default.
• W3037979376 hasConcept C2781017439 @default.
• W3037979376 hasConcept C42219234 @default.
• W3037979376 hasConcept C55493867 @default.
• W3037979376 hasConcept C71924100 @default.
• W3037979376 hasConcept C86803240 @default.
• W3037979376 hasConceptScore W3037979376C104317684 @default.
• W3037979376 hasConceptScore W3037979376C118552586 @default.
• W3037979376 hasConceptScore W3037979376C126322002 @default.
• W3037979376 hasConceptScore W3037979376C15744967 @default.
• W3037979376 hasConceptScore W3037979376C169760540 @default.
• W3037979376 hasConceptScore W3037979376C2776878037 @default.
• W3037979376 hasConceptScore W3037979376C2778117688 @default.
• W3037979376 hasConceptScore W3037979376C2778186239 @default.
• W3037979376 hasConceptScore W3037979376C2781017439 @default.
• W3037979376 hasConceptScore W3037979376C42219234 @default.
• W3037979376 hasConceptScore W3037979376C55493867 @default.
• W3037979376 hasConceptScore W3037979376C71924100 @default.

• next