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• W3037989825 abstract "Background . Both antioxidant and prooxidant activities have been previously reported for cerium oxide (CeO 2 ). The aim of this study was to investigate the effects of CeO 2 at different doses on changes in kidney tissues and markers in neonatal mice. Methods. We randomly divided 30 pregnant NMRI mice into five groups (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>6</mml:mn></mml:math> per group)—a control group and four groups treated with intraperitoneal (i.p.) administration of different doses of CeO 2 (10, 25, 80, or 250 mg/kg body weight (bw)) on gestation days (GD) 7 and GD14. At the end of the treatment period, we analyzed the kidney tissues and serum samples. The levels of two serum redox markers, malondialdehyde (MDA) and ferric reducing/antioxidant power (FRAP), were determined. Data were analyzed using one-way ANOVA and Tukey’s test, and a <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>P</mml:mi></mml:math> value of <0.05 was considered significant. Results . The mean total volumes of the renal corpuscle, glomeruli, and Bowman’s capsule membranes significantly increased, and there was a significant decrease in the mean total volume of Bowman’s space in the high-dose CeO 2 group compared to that in the control group. No statistically significant differences existed in the serum levels of MDA and FRAP in the treated and control groups. Conclusion . Our results suggest that high doses of CeO 2 impair fetal renal development in pregnant mice, which results in kidney damage. Therefore, CeO 2 administration during pregnancy could have dose-dependent adverse effects on the developing kidneys in neonates." @default.
• W3037989825 created "2020-07-02" @default.
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• W3037989825 date "2020-06-23" @default.
• W3037989825 modified "2023-09-23" @default.
• W3037989825 title "A Stereological Study of the Toxic Effects of Cerium Oxide during Pregnancy on Kidney Tissues in Neonatal NMRI Mice" @default.
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• W3037989825 doi "https://doi.org/10.1155/2020/9132724" @default.
• W3037989825 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7330649" @default.
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