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- W3037996857 abstract "Autophagy is a multistage catabolic process that mediates stress responses. However, the role of autophagy in epidermal proliferation, particularly under conditions when the epidermis becomes “activated” (hyperproliferative), remains unclear. We have shown that inhibition of Beclin 1, a key activator in the initiation phase of autophagy, attenuates imiquimod (IMQ)-induced epidermal hyperplasia in adult mice as well as naturally occurring hyperproliferation in neonatal mouse epidermis. Inhibition of Beclin 1 did not change the levels of several key inflammatory molecules or the numbers of immune cells in lesional skins. This indicates that autophagy does not affect inflammatory regulators in IMQ-treated mouse skin. Bioinformatic analysis combined with gene expression quantitative assays, revealed that a deficiency in autophagy decreases the expression of PDZ Binding Kinase (PBK), a regulator of the cell cycle, in mouse epidermis and human epidermal keratinocytes (HEKs). Interestingly, the decrease in PBK results in inhibition of proliferation in HEKs and such reduced proliferation can be rescued by activation of p38, the downstream signaling of PBK. Collectively, autophagy plays a positive role in epidermal proliferation, which is in part via regulating PBK expression." @default.
- W3037996857 created "2020-07-02" @default.
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- W3037996857 date "2020-06-29" @default.
- W3037996857 modified "2023-10-18" @default.
- W3037996857 title "Autophagy plays a positive role in induction of epidermal proliferation" @default.
- W3037996857 cites W1532206496 @default.
- W3037996857 cites W1592287085 @default.
- W3037996857 cites W1594493125 @default.
- W3037996857 cites W1872474147 @default.
- W3037996857 cites W1939997832 @default.
- W3037996857 cites W1972133970 @default.
- W3037996857 cites W1972519476 @default.
- W3037996857 cites W1976195903 @default.
- W3037996857 cites W1996725747 @default.
- W3037996857 cites W1998354357 @default.
- W3037996857 cites W2003380425 @default.
- W3037996857 cites W2009647581 @default.
- W3037996857 cites W2010672677 @default.
- W3037996857 cites W2012077729 @default.
- W3037996857 cites W2012391451 @default.
- W3037996857 cites W2014740187 @default.
- W3037996857 cites W2019263782 @default.
- W3037996857 cites W2020003175 @default.
- W3037996857 cites W2021196087 @default.
- W3037996857 cites W2024077088 @default.
- W3037996857 cites W2032968581 @default.
- W3037996857 cites W2034518661 @default.
- W3037996857 cites W2040156598 @default.
- W3037996857 cites W2041786942 @default.
- W3037996857 cites W2045113343 @default.
- W3037996857 cites W2047344004 @default.
- W3037996857 cites W2068062518 @default.
- W3037996857 cites W2076049418 @default.
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- W3037996857 cites W2082476985 @default.
- W3037996857 cites W2089755972 @default.
- W3037996857 cites W2090456761 @default.
- W3037996857 cites W2091148267 @default.
- W3037996857 cites W2091828932 @default.
- W3037996857 cites W2093510891 @default.
- W3037996857 cites W2095128503 @default.
- W3037996857 cites W2099321680 @default.
- W3037996857 cites W2103657395 @default.
- W3037996857 cites W2112006696 @default.
- W3037996857 cites W2115886998 @default.
- W3037996857 cites W2116367518 @default.
- W3037996857 cites W2128804867 @default.
- W3037996857 cites W2133297853 @default.
- W3037996857 cites W2134661506 @default.
- W3037996857 cites W2136861773 @default.
- W3037996857 cites W2147482627 @default.
- W3037996857 cites W2155606755 @default.
- W3037996857 cites W2157096314 @default.
- W3037996857 cites W2157527462 @default.
- W3037996857 cites W2163622884 @default.
- W3037996857 cites W2165750540 @default.
- W3037996857 cites W2168212241 @default.
- W3037996857 cites W2212288688 @default.
- W3037996857 cites W2217591243 @default.
- W3037996857 cites W2305435220 @default.
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- W3037996857 cites W2549951150 @default.
- W3037996857 cites W2602955853 @default.
- W3037996857 cites W2624672837 @default.
- W3037996857 cites W2752326209 @default.
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- W3037996857 cites W2766092928 @default.
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- W3037996857 cites W2911246983 @default.
- W3037996857 cites W2911962886 @default.
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- W3037996857 doi "https://doi.org/10.1096/fj.202000770rr" @default.
- W3037996857 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7688513" @default.
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- W3037996857 hasPublicationYear "2020" @default.
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