Matches in SemOpenAlex for { <https://semopenalex.org/work/W3038190055> ?p ?o ?g. }
- W3038190055 endingPage "277" @default.
- W3038190055 startingPage "277" @default.
- W3038190055 abstract "Investigation of glucose utilization during an infection is central to the study of energy metabolism. The heavy utilization of glucose by the malaria parasite, and the consequences of this process, have been investigated extensively. However, host glucose utilization during early infection has not been explored to date. In a first attempt, this article investigates the changes in the host glucose utilization in Balb/c mice infected with Plasmodium berghei ANKA using 13C-labeled glucose infusion followed by NMR spectroscopy. The results suggested significant alterations of liver, brain and red blood cell (RBC) glucose utilization during early infection when the parasitemia was <1%. At the pathway level, we observed a decrease in the shunt metabolite 2,3-bisphosphoglycerate in the RBCs. Glycolysis and pathways associated with it, along with fatty acid unsaturation, were altered in the liver. Significant changes were observed in the central carbon metabolic pathways in the brain. These results have implications in understanding the host physiology during early infection and pave the way for detailed flux analysis of the proposed perturbed pathways." @default.
- W3038190055 created "2020-07-10" @default.
- W3038190055 creator A5012042606 @default.
- W3038190055 creator A5019679277 @default.
- W3038190055 creator A5068323156 @default.
- W3038190055 creator A5079331432 @default.
- W3038190055 date "2020-07-07" @default.
- W3038190055 modified "2023-10-15" @default.
- W3038190055 title "Early Perturbations in Glucose Utilization in Malaria-Infected Murine Erythrocytes, Liver and Brain Observed by Metabolomics" @default.
- W3038190055 cites W1498259559 @default.
- W3038190055 cites W1533659084 @default.
- W3038190055 cites W1622422817 @default.
- W3038190055 cites W1787279181 @default.
- W3038190055 cites W1800815393 @default.
- W3038190055 cites W1967904470 @default.
- W3038190055 cites W1978628047 @default.
- W3038190055 cites W1997455728 @default.
- W3038190055 cites W1998394649 @default.
- W3038190055 cites W2010680706 @default.
- W3038190055 cites W2026804604 @default.
- W3038190055 cites W2028150606 @default.
- W3038190055 cites W2033783179 @default.
- W3038190055 cites W2034572121 @default.
- W3038190055 cites W2035852204 @default.
- W3038190055 cites W2039227742 @default.
- W3038190055 cites W2046798812 @default.
- W3038190055 cites W2046829645 @default.
- W3038190055 cites W2050055399 @default.
- W3038190055 cites W2054080005 @default.
- W3038190055 cites W2059535228 @default.
- W3038190055 cites W2065380426 @default.
- W3038190055 cites W2068127839 @default.
- W3038190055 cites W2095134469 @default.
- W3038190055 cites W2107954822 @default.
- W3038190055 cites W2111506982 @default.
- W3038190055 cites W2114546524 @default.
- W3038190055 cites W2120724865 @default.
- W3038190055 cites W2126442353 @default.
- W3038190055 cites W2132979335 @default.
- W3038190055 cites W2147591722 @default.
- W3038190055 cites W2147686037 @default.
- W3038190055 cites W2164620650 @default.
- W3038190055 cites W2167647060 @default.
- W3038190055 cites W2320681728 @default.
- W3038190055 cites W2340617137 @default.
- W3038190055 cites W2442066021 @default.
- W3038190055 cites W2477113096 @default.
- W3038190055 cites W2598681194 @default.
- W3038190055 cites W2761445330 @default.
- W3038190055 cites W2883644976 @default.
- W3038190055 cites W2978580969 @default.
- W3038190055 cites W2995288161 @default.
- W3038190055 cites W4251323893 @default.
- W3038190055 cites W4252920642 @default.
- W3038190055 doi "https://doi.org/10.3390/metabo10070277" @default.
- W3038190055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7407383" @default.
- W3038190055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32645891" @default.
- W3038190055 hasPublicationYear "2020" @default.
- W3038190055 type Work @default.
- W3038190055 sameAs 3038190055 @default.
- W3038190055 citedByCount "9" @default.
- W3038190055 countsByYear W30381900552021 @default.
- W3038190055 countsByYear W30381900552022 @default.
- W3038190055 countsByYear W30381900552023 @default.
- W3038190055 crossrefType "journal-article" @default.
- W3038190055 hasAuthorship W3038190055A5012042606 @default.
- W3038190055 hasAuthorship W3038190055A5019679277 @default.
- W3038190055 hasAuthorship W3038190055A5068323156 @default.
- W3038190055 hasAuthorship W3038190055A5079331432 @default.
- W3038190055 hasBestOaLocation W30381900551 @default.
- W3038190055 hasConcept C135870905 @default.
- W3038190055 hasConcept C17093226 @default.
- W3038190055 hasConcept C192989942 @default.
- W3038190055 hasConcept C20251656 @default.
- W3038190055 hasConcept C203014093 @default.
- W3038190055 hasConcept C20904676 @default.
- W3038190055 hasConcept C21565614 @default.
- W3038190055 hasConcept C2775867548 @default.
- W3038190055 hasConcept C2777237215 @default.
- W3038190055 hasConcept C2777477808 @default.
- W3038190055 hasConcept C2778048844 @default.
- W3038190055 hasConcept C2778371730 @default.
- W3038190055 hasConcept C3409486 @default.
- W3038190055 hasConcept C55493867 @default.
- W3038190055 hasConcept C60644358 @default.
- W3038190055 hasConcept C62231903 @default.
- W3038190055 hasConcept C86803240 @default.
- W3038190055 hasConceptScore W3038190055C135870905 @default.
- W3038190055 hasConceptScore W3038190055C17093226 @default.
- W3038190055 hasConceptScore W3038190055C192989942 @default.
- W3038190055 hasConceptScore W3038190055C20251656 @default.
- W3038190055 hasConceptScore W3038190055C203014093 @default.
- W3038190055 hasConceptScore W3038190055C20904676 @default.
- W3038190055 hasConceptScore W3038190055C21565614 @default.
- W3038190055 hasConceptScore W3038190055C2775867548 @default.
- W3038190055 hasConceptScore W3038190055C2777237215 @default.
- W3038190055 hasConceptScore W3038190055C2777477808 @default.
- W3038190055 hasConceptScore W3038190055C2778048844 @default.