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- W3038258889 abstract "Aim To measure the serum levels of strong angiostatic and synaptogenetic molecules thrombospondin-1 (TSP-1) and thrombospondin-2 (TSP-2) in patients with temporal lobe epilepsy (TLE) and surgery. Material and methods In this prospective study, 20 patients operated for TLE and 20 healthy subjects were included. Serum levels of TSP-1 and TSP-2 were measured using enzyme-linked immunosorbent assay (ELISA). Results Our findings showed that both groups had higher serum levels of both molecules before surgery than 10 days ?after? Surgery However, a significant difference was noted between ?before? and after surgery regarding TSP-1 (p=0.00001). Although a marked decrease was found after surgery with respect to TSP-2, the difference did not reach statistical significance (p=0.22). In patients with TLE, serum levels of both molecules ?before? surgery were found to be significantly higher than in healthy controls (TSP-1, p=0.00001; TSP-2, p=0.007). Conclusion Serum levels of TSP-1 and TSP-2 are determined to be higher in patients with TLE than in healthy subjects, and the resection of epileptogenic tissues decreases the serum levels of these molecules. Future studies should involve a higher number of patients with serial serum levels of TSP-1 and TSP-2 at the long-term follow-up to correlate with seizure outcome." @default.
- W3038258889 created "2020-07-10" @default.
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- W3038258889 date "2020-01-01" @default.
- W3038258889 modified "2023-10-18" @default.
- W3038258889 title "Circulating levels of thrombospondin-1 and thrombospondin-2 in patients with temporal lobe epilepsy before and after surgery" @default.
- W3038258889 doi "https://doi.org/10.5137/1019-5149.jtn.29081-20.4" @default.
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