Matches in SemOpenAlex for { <https://semopenalex.org/work/W3038282749> ?p ?o ?g. }
- W3038282749 endingPage "572" @default.
- W3038282749 startingPage "572" @default.
- W3038282749 abstract "Wnt and mammalian target of rapamycin (mTOR) are major molecular signaling pathways associated with the development and progression of tumor, as well as the maintenance and proliferation of cancer stem cells (CSCs), in colorectal cancer (CRC). Identifying patients at risk of poor prognosis is important to determining whether to add adjuvant treatment in stage II CRC and thus improve survival. In the present study, we evaluated the prognostic value of Wnt, mTOR, and CSC markers as survival predictors in stage II CRC.We identified 148 cases of stage II CRC and acquired their tumor tissue. Tissue microarrays for immunohistochemical staining were constructed, and the expressions of CD166, CD44, EphB2, β-catenin, pS6 were evaluated using immunohistochemical staining.The expressions of CD166 (p=0.045) and pS6 (p=0.045) and co-expression of pS6/CD166 (p=0.005), pS6/CD44 (p=0.042), and pS6/CD44/CD166 (p=0.013) were negatively correlated with cancer-specific survival. Cox proportional hazard analysis showed the combination of CD166/pS6 [hazard ratio, 9.42; 95% confidence interval, 2.36-37.59; p=0.002] to be the most significant predictor related with decreased cancer-specific survival. In addition, co-expression of CD44/CD166 (p=0.017), CD166/β-catenin (p=0.036), CD44/β-catenin (p=0.001), and CD44/CD166/β-catenin (p=0.001) were significant factors associated with liver metastasis.Specific combinations of CSC markers and β-catenin/mTOR signaling could be a significant predictor of poor survival in stage II CRC." @default.
- W3038282749 created "2020-07-10" @default.
- W3038282749 creator A5004300224 @default.
- W3038282749 creator A5009662056 @default.
- W3038282749 creator A5017922574 @default.
- W3038282749 creator A5025909748 @default.
- W3038282749 creator A5026148041 @default.
- W3038282749 creator A5029243528 @default.
- W3038282749 creator A5031754381 @default.
- W3038282749 creator A5036171145 @default.
- W3038282749 creator A5059865111 @default.
- W3038282749 creator A5089456278 @default.
- W3038282749 date "2020-01-01" @default.
- W3038282749 modified "2023-09-25" @default.
- W3038282749 title "mTOR Signaling Combined with Cancer Stem Cell Markers as a Survival Predictor in Stage II Colorectal Cancer" @default.
- W3038282749 cites W1525899559 @default.
- W3038282749 cites W1967137553 @default.
- W3038282749 cites W1977269216 @default.
- W3038282749 cites W1981401376 @default.
- W3038282749 cites W2026857316 @default.
- W3038282749 cites W2030866834 @default.
- W3038282749 cites W2033338515 @default.
- W3038282749 cites W2034057314 @default.
- W3038282749 cites W2047694154 @default.
- W3038282749 cites W2060993856 @default.
- W3038282749 cites W2078310910 @default.
- W3038282749 cites W2081447858 @default.
- W3038282749 cites W2093405022 @default.
- W3038282749 cites W2100125385 @default.
- W3038282749 cites W2102085111 @default.
- W3038282749 cites W2105915644 @default.
- W3038282749 cites W2111840545 @default.
- W3038282749 cites W2119284420 @default.
- W3038282749 cites W2119938514 @default.
- W3038282749 cites W2124715710 @default.
- W3038282749 cites W2127951115 @default.
- W3038282749 cites W2128042794 @default.
- W3038282749 cites W2134138119 @default.
- W3038282749 cites W2136909908 @default.
- W3038282749 cites W2141768150 @default.
- W3038282749 cites W2146167376 @default.
- W3038282749 cites W2147369568 @default.
- W3038282749 cites W2157910818 @default.
- W3038282749 cites W2168680994 @default.
- W3038282749 cites W2270126973 @default.
- W3038282749 cites W2340014362 @default.
- W3038282749 cites W2342085497 @default.
- W3038282749 cites W2513746879 @default.
- W3038282749 cites W2578248437 @default.
- W3038282749 cites W2598830924 @default.
- W3038282749 cites W2599835027 @default.
- W3038282749 cites W2736837808 @default.
- W3038282749 cites W2752213732 @default.
- W3038282749 cites W2885659166 @default.
- W3038282749 doi "https://doi.org/10.3349/ymj.2020.61.7.572" @default.
- W3038282749 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7329744" @default.
- W3038282749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32608200" @default.
- W3038282749 hasPublicationYear "2020" @default.
- W3038282749 type Work @default.
- W3038282749 sameAs 3038282749 @default.
- W3038282749 citedByCount "4" @default.
- W3038282749 countsByYear W30382827492021 @default.
- W3038282749 crossrefType "journal-article" @default.
- W3038282749 hasAuthorship W3038282749A5004300224 @default.
- W3038282749 hasAuthorship W3038282749A5009662056 @default.
- W3038282749 hasAuthorship W3038282749A5017922574 @default.
- W3038282749 hasAuthorship W3038282749A5025909748 @default.
- W3038282749 hasAuthorship W3038282749A5026148041 @default.
- W3038282749 hasAuthorship W3038282749A5029243528 @default.
- W3038282749 hasAuthorship W3038282749A5031754381 @default.
- W3038282749 hasAuthorship W3038282749A5036171145 @default.
- W3038282749 hasAuthorship W3038282749A5059865111 @default.
- W3038282749 hasAuthorship W3038282749A5089456278 @default.
- W3038282749 hasBestOaLocation W30382827491 @default.
- W3038282749 hasConcept C121608353 @default.
- W3038282749 hasConcept C126322002 @default.
- W3038282749 hasConcept C137620995 @default.
- W3038282749 hasConcept C143998085 @default.
- W3038282749 hasConcept C1491633281 @default.
- W3038282749 hasConcept C193270364 @default.
- W3038282749 hasConcept C204232928 @default.
- W3038282749 hasConcept C207103383 @default.
- W3038282749 hasConcept C2779013556 @default.
- W3038282749 hasConcept C2780932548 @default.
- W3038282749 hasConcept C30145163 @default.
- W3038282749 hasConcept C44249647 @default.
- W3038282749 hasConcept C502942594 @default.
- W3038282749 hasConcept C526805850 @default.
- W3038282749 hasConcept C54355233 @default.
- W3038282749 hasConcept C55427017 @default.
- W3038282749 hasConcept C55493867 @default.
- W3038282749 hasConcept C62478195 @default.
- W3038282749 hasConcept C71924100 @default.
- W3038282749 hasConcept C86554907 @default.
- W3038282749 hasConcept C86803240 @default.
- W3038282749 hasConceptScore W3038282749C121608353 @default.
- W3038282749 hasConceptScore W3038282749C126322002 @default.
- W3038282749 hasConceptScore W3038282749C137620995 @default.