Matches in SemOpenAlex for { <https://semopenalex.org/work/W3038429759> ?p ?o ?g. }
- W3038429759 endingPage "250" @default.
- W3038429759 startingPage "239" @default.
- W3038429759 abstract "Astragalus membranaceus is a staple of Traditional Chinese Medicine being one of the oldest medicinal herbs listed in the material medica of Chinese herbal medicine. Chinese herbalists have used Astragalus to help the human body fight a variety of diseases. Modern herbalists utilize Astragalus primarily as an immunostimulant to prevent common infection and aid in the recovery following infection. Historically, the biological activities associated with Astragalus have been accounted for, at least in part, to several constituents present in the botanical including saponins and polysaccharides. We propose that in addition to these constituents, compounds from endophytic (or epiphytic) bacteria present in (or on) the roots of Astragalus may have an important biological role. Lipopolysaccharides and lipoproteins are major components of Gram-negative bacteria and highly potent activators of the innate immune response. Our data supports a direct correlation between the level of immune gene induction and the level of lipopolysaccharides/lipoproteins present in the Astragalus extract. We demonstrate that extracts from Astragalus specifically activate Toll-like and NOD-like receptors involved in the recognition and response to bacterial constituents and that removal of the lipopolysaccharide/lipoprotein from the Astragalus extract reduced the level of this response. The results support that many immune enhancing botanicals have established a symbiotic relationship with Gram-negative bacteria and that the immune enhancing effect of these botanical extracts on the body may not only be due to endogenous plant compounds, but endophytic (or epiphytic) bacterial components as well." @default.
- W3038429759 created "2020-07-10" @default.
- W3038429759 creator A5015955869 @default.
- W3038429759 creator A5067418874 @default.
- W3038429759 creator A5075823747 @default.
- W3038429759 creator A5084834429 @default.
- W3038429759 creator A5088708459 @default.
- W3038429759 date "2020-06-29" @default.
- W3038429759 modified "2023-10-03" @default.
- W3038429759 title "The Role of Endophytic/Epiphytic Bacterial Constituents in the Immunostimulatory Activity of the Botanical, Astragalus membranaceus." @default.
- W3038429759 cites W1474575430 @default.
- W3038429759 cites W1511447223 @default.
- W3038429759 cites W1559405972 @default.
- W3038429759 cites W1598102586 @default.
- W3038429759 cites W1739247159 @default.
- W3038429759 cites W1870522047 @default.
- W3038429759 cites W1910210525 @default.
- W3038429759 cites W1969072247 @default.
- W3038429759 cites W1972847358 @default.
- W3038429759 cites W1973256703 @default.
- W3038429759 cites W1978611085 @default.
- W3038429759 cites W1989950165 @default.
- W3038429759 cites W1996146979 @default.
- W3038429759 cites W1999325378 @default.
- W3038429759 cites W2003312913 @default.
- W3038429759 cites W2011945823 @default.
- W3038429759 cites W2014572899 @default.
- W3038429759 cites W2026274922 @default.
- W3038429759 cites W2030855657 @default.
- W3038429759 cites W2032537471 @default.
- W3038429759 cites W2037376801 @default.
- W3038429759 cites W2039662911 @default.
- W3038429759 cites W2041168913 @default.
- W3038429759 cites W2045277695 @default.
- W3038429759 cites W2049605253 @default.
- W3038429759 cites W2051027058 @default.
- W3038429759 cites W2057132393 @default.
- W3038429759 cites W2057234379 @default.
- W3038429759 cites W2059800991 @default.
- W3038429759 cites W2062711512 @default.
- W3038429759 cites W2081255244 @default.
- W3038429759 cites W2082459636 @default.
- W3038429759 cites W2088024461 @default.
- W3038429759 cites W2090940365 @default.
- W3038429759 cites W2091614628 @default.
- W3038429759 cites W2095164365 @default.
- W3038429759 cites W2096736130 @default.
- W3038429759 cites W2097919928 @default.
- W3038429759 cites W2099556958 @default.
- W3038429759 cites W2104063220 @default.
- W3038429759 cites W2105801844 @default.
- W3038429759 cites W2107958058 @default.
- W3038429759 cites W2109491705 @default.
- W3038429759 cites W2117231950 @default.
- W3038429759 cites W2120763351 @default.
- W3038429759 cites W2128173047 @default.
- W3038429759 cites W2135623402 @default.
- W3038429759 cites W2143214524 @default.
- W3038429759 cites W2147839345 @default.
- W3038429759 cites W2149711855 @default.
- W3038429759 cites W2151087586 @default.
- W3038429759 cites W2154055341 @default.
- W3038429759 cites W2154993590 @default.
- W3038429759 cites W2159271918 @default.
- W3038429759 cites W2159300071 @default.
- W3038429759 cites W2161208630 @default.
- W3038429759 cites W2162452084 @default.
- W3038429759 cites W2165626477 @default.
- W3038429759 cites W2168902372 @default.
- W3038429759 cites W2172146703 @default.
- W3038429759 cites W2196530082 @default.
- W3038429759 cites W2281592478 @default.
- W3038429759 cites W2288152950 @default.
- W3038429759 cites W2301901803 @default.
- W3038429759 cites W2392919422 @default.
- W3038429759 cites W2509944824 @default.
- W3038429759 cites W2534453077 @default.
- W3038429759 cites W2539825657 @default.
- W3038429759 cites W2542758428 @default.
- W3038429759 cites W2586470749 @default.
- W3038429759 cites W2738649715 @default.
- W3038429759 cites W2748890551 @default.
- W3038429759 cites W2769759443 @default.
- W3038429759 cites W2789868534 @default.
- W3038429759 cites W2791945868 @default.
- W3038429759 cites W2804721962 @default.
- W3038429759 cites W2805077839 @default.
- W3038429759 cites W2883047508 @default.
- W3038429759 cites W2911079393 @default.
- W3038429759 cites W2924030508 @default.
- W3038429759 cites W2947415289 @default.
- W3038429759 cites W2964424503 @default.
- W3038429759 cites W2970061921 @default.
- W3038429759 cites W2983893799 @default.
- W3038429759 cites W1889242083 @default.
- W3038429759 cites W2024738595 @default.
- W3038429759 cites W2336886146 @default.
- W3038429759 cites W2419531553 @default.