FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3038503485> ?p ?o ?g. }

• W3038503485 endingPage "433" @default.
• W3038503485 startingPage "425" @default.
• W3038503485 abstract "Background Recent reports suggest that the negative association between diabetes mellitus and abdominal aortic aneurysm (AAA) may be driven by metformin, the world's most common antidiabetic drug rather than diabetes per se. We sought to investigate the association among AAA growth rate, chemokine profile, and metformin prescription in a contemporary Swedish cohort. Methods Patients under surveillance for small AAA were identified at 4 Swedish vascular centers with active AAA screening programs. Annual AAA growth rate, medical history, and prescribed medications were recorded for linear regression analysis. In a subset of patients with AAA and control subjects without AAA or diabetes, plasma samples were available and analyzed for 40 inflammatory chemokines. Results A total of 526 patients were included for AAA growth analysis: 428 without type 2 diabetes mellitus (T2DM), 65 with T2DM and metformin prescription, and 33 with T2DM but without metformin prescription. Patients were included from 2005 to 2017 with mean follow-up of 3.2 (1.7) years and median annual AAA growth rate 1.6 mm, range −4.8 to 15.4 mm. Mean (standard deviation) annual AAA growth rates were 2.3 (2.2) mm in non-T2DM patients versus 1.1 (1.1) mm in patients with T2DM with metformin prescription and 1.6 (1.4) mm among those with T2DM without metformin prescription. With non-T2DM patients as reference in an unadjusted and 2 adjusted models, metformin prescription was significantly associated with reduced AAA growth rate (P  Conclusions Metformin prescription is associated with reduced AAA growth rate, possibly mediated by broad anti-inflammatory effects. A randomized controlled trial is needed to determine what role metformin may play in AAA disease, particularly in the absence of T2DM." @default.
• W3038503485 created "2020-07-10" @default.
• W3038503485 creator A5004241415 @default.
• W3038503485 creator A5029419578 @default.
• W3038503485 creator A5038479977 @default.
• W3038503485 creator A5039036487 @default.
• W3038503485 creator A5048041435 @default.
• W3038503485 creator A5054836912 @default.
• W3038503485 creator A5059462706 @default.
• W3038503485 creator A5068493192 @default.
• W3038503485 date "2021-01-01" @default.
• W3038503485 modified "2023-10-12" @default.
• W3038503485 title "Metformin Prescription Associated with Reduced Abdominal Aortic Aneurysm Growth Rate and Reduced Chemokine Expression in a Swedish Cohort" @default.
• W3038503485 cites W2022490412 @default.
• W3038503485 cites W2031565266 @default.
• W3038503485 cites W2046782528 @default.
• W3038503485 cites W2056435044 @default.
• W3038503485 cites W2074304438 @default.
• W3038503485 cites W2112744681 @default.
• W3038503485 cites W2130622683 @default.
• W3038503485 cites W2135340282 @default.
• W3038503485 cites W2153071870 @default.
• W3038503485 cites W2154696423 @default.
• W3038503485 cites W2160088494 @default.
• W3038503485 cites W2338299575 @default.
• W3038503485 cites W2511762120 @default.
• W3038503485 cites W2520202015 @default.
• W3038503485 cites W2680386216 @default.
• W3038503485 cites W2740802742 @default.
• W3038503485 cites W2776247479 @default.
• W3038503485 cites W2787354007 @default.
• W3038503485 cites W2801103910 @default.
• W3038503485 cites W2806453500 @default.
• W3038503485 cites W2888883909 @default.
• W3038503485 cites W2890735944 @default.
• W3038503485 cites W2902783010 @default.
• W3038503485 cites W2940715904 @default.
• W3038503485 cites W2960200798 @default.
• W3038503485 cites W2964987917 @default.
• W3038503485 doi "https://doi.org/10.1016/j.avsg.2020.06.039" @default.
• W3038503485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32619497" @default.
• W3038503485 hasPublicationYear "2021" @default.
• W3038503485 type Work @default.
• W3038503485 sameAs 3038503485 @default.
• W3038503485 citedByCount "21" @default.
• W3038503485 countsByYear W30385034852021 @default.
• W3038503485 countsByYear W30385034852022 @default.
• W3038503485 countsByYear W30385034852023 @default.
• W3038503485 crossrefType "journal-article" @default.
• W3038503485 hasAuthorship W3038503485A5004241415 @default.
• W3038503485 hasAuthorship W3038503485A5029419578 @default.
• W3038503485 hasAuthorship W3038503485A5038479977 @default.
• W3038503485 hasAuthorship W3038503485A5039036487 @default.
• W3038503485 hasAuthorship W3038503485A5048041435 @default.
• W3038503485 hasAuthorship W3038503485A5054836912 @default.
• W3038503485 hasAuthorship W3038503485A5059462706 @default.
• W3038503485 hasAuthorship W3038503485A5068493192 @default.
• W3038503485 hasBestOaLocation W30385034851 @default.
• W3038503485 hasConcept C126322002 @default.
• W3038503485 hasConcept C13373296 @default.
• W3038503485 hasConcept C141071460 @default.
• W3038503485 hasConcept C164705383 @default.
• W3038503485 hasConcept C170493617 @default.
• W3038503485 hasConcept C2426938 @default.
• W3038503485 hasConcept C2776098176 @default.
• W3038503485 hasConcept C2779306644 @default.
• W3038503485 hasConcept C2779993416 @default.
• W3038503485 hasConcept C2780120127 @default.
• W3038503485 hasConcept C2780323712 @default.
• W3038503485 hasConcept C71924100 @default.
• W3038503485 hasConcept C72563966 @default.
• W3038503485 hasConcept C98274493 @default.
• W3038503485 hasConceptScore W3038503485C126322002 @default.
• W3038503485 hasConceptScore W3038503485C13373296 @default.
• W3038503485 hasConceptScore W3038503485C141071460 @default.
• W3038503485 hasConceptScore W3038503485C164705383 @default.
• W3038503485 hasConceptScore W3038503485C170493617 @default.
• W3038503485 hasConceptScore W3038503485C2426938 @default.
• W3038503485 hasConceptScore W3038503485C2776098176 @default.
• W3038503485 hasConceptScore W3038503485C2779306644 @default.
• W3038503485 hasConceptScore W3038503485C2779993416 @default.
• W3038503485 hasConceptScore W3038503485C2780120127 @default.
• W3038503485 hasConceptScore W3038503485C2780323712 @default.
• W3038503485 hasConceptScore W3038503485C71924100 @default.
• W3038503485 hasConceptScore W3038503485C72563966 @default.
• W3038503485 hasConceptScore W3038503485C98274493 @default.
• W3038503485 hasFunder F4320322169 @default.
• W3038503485 hasFunder F4320322225 @default.
• W3038503485 hasFunder F4320322581 @default.
• W3038503485 hasLocation W30385034851 @default.
• W3038503485 hasLocation W30385034852 @default.
• W3038503485 hasLocation W30385034853 @default.
• W3038503485 hasOpenAccess W3038503485 @default.
• W3038503485 hasPrimaryLocation W30385034851 @default.
• W3038503485 hasRelatedWork W2004099729 @default.
• W3038503485 hasRelatedWork W2016166748 @default.
• W3038503485 hasRelatedWork W2021250647 @default.
• W3038503485 hasRelatedWork W2023912825 @default.

• next