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- W3038516106 abstract "Modern diagnosis of biopsied muscle requires a multidisciplinary approach, including routine histology and immunohistochemistry, cryosectioning for histochemistry, and (in selected cases) electron microscopy or biochemical evaluation. Routine paraffin embedding offers excellent histological detail. Cryosections provide fresh tissue for histochemical reactions that delineate fiber types and reveal special architectural alterations. Electron microscopy is applied in selected instances to provide diagnostic detail not otherwise apparent. Biochemical analysis of frozen tissue is used to define certain inborn errors of metabolism. This integrated approach allows diagnostic precision far beyond the limited information available from routine paraffin sections. We present examples of diagnoses made possible using these special techniques. Chronic, slowly progressive neuropathies show grouping of fiber types and target fiber formation, apparent in special histochemical preparations. Routine histological preparations may be normal or show only nonspecific changes. Central core disease shows areas of pallor evident in the central areas of many myofibers in histochemical preparations." @default.
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- W3038516106 date "1998-07-01" @default.
- W3038516106 modified "2023-10-16" @default.
- W3038516106 title "Muscle Biopsy: Use of Cryosections, Histochemistry, and Electron Microscopy for Diagnosis" @default.
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- W3038516106 doi "https://doi.org/10.1017/s1431927600025538" @default.
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