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- W3038537724 abstract "Positive associations between cerebral microbleeds (CMBs) and APOE-ε4 (apolipoprotein E) genotype have been reported in Alzheimer’s disease, but show conflicting results. We investigated the effect of APOE genotype on CMBs in a cohort of cognitively unimpaired middle- and old-aged individuals enriched for APOE-ε4 genotype. Participants from ALFA (Alzheimer and Families) cohort were included and their magnetic resonance scans assessed (n = 564, 50% APOE-ε4 carriers). Quantitative magnetic resonance analyses included visual ratings, atrophy measures, and white matter hyperintensity (WMH) segmentations. The prevalence of CMBs was 17%, increased with age (p < 0.05), and followed an increasing trend paralleling APOE-ε4 dose. The number of CMBs was significantly higher in APOE-ε4 homozygotes compared to heterozygotes and non-carriers (p < 0.05). This association was driven by lobar CMBs (p < 0.05). CMBs co-localized with WMH (p < 0.05). No associations between CMBs and APOE-ε2, gray matter volumes, and cognitive performance were found. Our results suggest that cerebral vessels of APOE-ε4 homozygous are more fragile, especially in lobar locations. Co-occurrence of CMBs and WMH suggests that such changes localize in areas with increased vascular vulnerability." @default.
- W3038537724 created "2020-07-10" @default.
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- W3038537724 date "2020-11-01" @default.
- W3038537724 modified "2023-10-06" @default.
- W3038537724 title "The relation between APOE genotype and cerebral microbleeds in cognitively unimpaired middle- and old-aged individuals" @default.
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- W3038537724 cites W1974034298 @default.
- W3038537724 cites W1980727483 @default.
- W3038537724 cites W1981666590 @default.
- W3038537724 cites W1991952617 @default.
- W3038537724 cites W1992608632 @default.
- W3038537724 cites W1993102117 @default.
- W3038537724 cites W2011640156 @default.
- W3038537724 cites W2040138770 @default.
- W3038537724 cites W2047753872 @default.
- W3038537724 cites W2051063043 @default.
- W3038537724 cites W2052992787 @default.
- W3038537724 cites W2054422278 @default.
- W3038537724 cites W2054931992 @default.
- W3038537724 cites W2064777739 @default.
- W3038537724 cites W2067766876 @default.
- W3038537724 cites W2074747084 @default.
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- W3038537724 cites W2127890285 @default.
- W3038537724 cites W2128317000 @default.
- W3038537724 cites W2128581044 @default.
- W3038537724 cites W2132396002 @default.
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- W3038537724 cites W2147883225 @default.
- W3038537724 cites W2148972503 @default.
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- W3038537724 cites W2157648440 @default.
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- W3038537724 cites W2168338439 @default.
- W3038537724 cites W2171346860 @default.
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- W3038537724 cites W2766173922 @default.
- W3038537724 cites W2768948569 @default.
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- W3038537724 doi "https://doi.org/10.1016/j.neurobiolaging.2020.06.015" @default.
- W3038537724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32791423" @default.
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