Matches in SemOpenAlex for { <https://semopenalex.org/work/W3038603985> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W3038603985 endingPage "546" @default.
- W3038603985 startingPage "541" @default.
- W3038603985 abstract "Despite efficacy in HCV eradication, direct-acting antiviral (DAA) therapy has raised controversies around their impact on hepatocellular carcinoma (HCC) incidence. Herein we reported the first Australian data on HCC incidence in DAA-treated HCV patients with advanced fibrosis/cirrhosis. We conducted a retrospective single center study of DAA-treated HCV patients with advanced fibrosis/cirrhosis from April 2015 to December 2017. Patients with prior HCC were included if they had complete response to HCC treatment. Among 138 patients who completed DAA therapy, 133 (96.4%) achieved sustained virologic response (median follow-up 23.8 months). Ten had prior HCC and 5/10 (50.0%) developed recurrence, while de novo HCC developed in 7/128 (5.5%). Median time from DAA to HCC diagnosis was 34 weeks in recurrent HCC vs. de novo 52 weeks (P = 0.159). In patients with prior HCC, those with recurrence (vs. without) had shorter median time between last HCC treatment and DAA (12 vs. 164 weeks, P < 0.001). On bivariate analysis, failed sustained virologic response at 12 weeks (SVR12) (P = 0.011), platelets (P = 0.005), model for end-stage liver disease (MELD) score (P = 0.029), alpha fetoprotein (AFP) (P = 0.013), and prior HCC (P < 0.001) were associated with HCC post-DAA. On multivariate analysis, significant factors were prior HCC (OR = 4.80; 95% CI: 1.47–48.50; P = 0.010), failed SVR12 (OR = 2.83; 95% CI: 1.71–16.30; P = 0.016) and platelets (OR = 0.97; 95% CI: 0.95–0.99; P = 0.009). Our study demonstrates a high incidence of recurrent HCC in HCV patients with advanced fibrosis/cirrhosis treated with DAA. Factors associated with HCC development post-DAA were more advanced liver disease, failed SVR12 and prior HCC, with higher rates of recurrence in those who started DAA earlier." @default.
- W3038603985 created "2020-07-10" @default.
- W3038603985 creator A5038842219 @default.
- W3038603985 creator A5053863653 @default.
- W3038603985 creator A5080231753 @default.
- W3038603985 creator A5081182002 @default.
- W3038603985 creator A5087140964 @default.
- W3038603985 date "2020-12-01" @default.
- W3038603985 modified "2023-10-13" @default.
- W3038603985 title "Hepatocellular carcinoma incidence post direct-acting antivirals in hepatitis C-related advanced fibrosis/cirrhosis patients in Australia" @default.
- W3038603985 cites W2021207134 @default.
- W3038603985 cites W2027498662 @default.
- W3038603985 cites W2029055742 @default.
- W3038603985 cites W2098986413 @default.
- W3038603985 cites W2103618797 @default.
- W3038603985 cites W2118698732 @default.
- W3038603985 cites W2185218296 @default.
- W3038603985 cites W2291726879 @default.
- W3038603985 cites W2335913920 @default.
- W3038603985 cites W2419146391 @default.
- W3038603985 cites W2429522722 @default.
- W3038603985 cites W2467713285 @default.
- W3038603985 cites W2514130042 @default.
- W3038603985 cites W2583713481 @default.
- W3038603985 cites W2605644052 @default.
- W3038603985 cites W2742937844 @default.
- W3038603985 cites W2744914748 @default.
- W3038603985 cites W2751945693 @default.
- W3038603985 cites W2796067155 @default.
- W3038603985 cites W2797952741 @default.
- W3038603985 cites W2910695573 @default.
- W3038603985 doi "https://doi.org/10.1016/j.hbpd.2020.06.013" @default.
- W3038603985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32660841" @default.
- W3038603985 hasPublicationYear "2020" @default.
- W3038603985 type Work @default.
- W3038603985 sameAs 3038603985 @default.
- W3038603985 citedByCount "6" @default.
- W3038603985 countsByYear W30386039852021 @default.
- W3038603985 countsByYear W30386039852022 @default.
- W3038603985 countsByYear W30386039852023 @default.
- W3038603985 crossrefType "journal-article" @default.
- W3038603985 hasAuthorship W3038603985A5038842219 @default.
- W3038603985 hasAuthorship W3038603985A5053863653 @default.
- W3038603985 hasAuthorship W3038603985A5080231753 @default.
- W3038603985 hasAuthorship W3038603985A5081182002 @default.
- W3038603985 hasAuthorship W3038603985A5087140964 @default.
- W3038603985 hasConcept C120665830 @default.
- W3038603985 hasConcept C121332964 @default.
- W3038603985 hasConcept C126322002 @default.
- W3038603985 hasConcept C203014093 @default.
- W3038603985 hasConcept C2522874641 @default.
- W3038603985 hasConcept C2776408679 @default.
- W3038603985 hasConcept C2776455275 @default.
- W3038603985 hasConcept C2777075537 @default.
- W3038603985 hasConcept C2777214474 @default.
- W3038603985 hasConcept C2778019345 @default.
- W3038603985 hasConcept C61511704 @default.
- W3038603985 hasConcept C71924100 @default.
- W3038603985 hasConcept C90924648 @default.
- W3038603985 hasConceptScore W3038603985C120665830 @default.
- W3038603985 hasConceptScore W3038603985C121332964 @default.
- W3038603985 hasConceptScore W3038603985C126322002 @default.
- W3038603985 hasConceptScore W3038603985C203014093 @default.
- W3038603985 hasConceptScore W3038603985C2522874641 @default.
- W3038603985 hasConceptScore W3038603985C2776408679 @default.
- W3038603985 hasConceptScore W3038603985C2776455275 @default.
- W3038603985 hasConceptScore W3038603985C2777075537 @default.
- W3038603985 hasConceptScore W3038603985C2777214474 @default.
- W3038603985 hasConceptScore W3038603985C2778019345 @default.
- W3038603985 hasConceptScore W3038603985C61511704 @default.
- W3038603985 hasConceptScore W3038603985C71924100 @default.
- W3038603985 hasConceptScore W3038603985C90924648 @default.
- W3038603985 hasIssue "6" @default.
- W3038603985 hasLocation W30386039851 @default.
- W3038603985 hasOpenAccess W3038603985 @default.
- W3038603985 hasPrimaryLocation W30386039851 @default.
- W3038603985 hasRelatedWork W2147058584 @default.
- W3038603985 hasRelatedWork W2259240001 @default.
- W3038603985 hasRelatedWork W2357755457 @default.
- W3038603985 hasRelatedWork W2388479797 @default.
- W3038603985 hasRelatedWork W2402703564 @default.
- W3038603985 hasRelatedWork W2412414326 @default.
- W3038603985 hasRelatedWork W2803171320 @default.
- W3038603985 hasRelatedWork W2892191661 @default.
- W3038603985 hasRelatedWork W4312114639 @default.
- W3038603985 hasRelatedWork W4319336998 @default.
- W3038603985 hasVolume "19" @default.
- W3038603985 isParatext "false" @default.
- W3038603985 isRetracted "false" @default.
- W3038603985 magId "3038603985" @default.
- W3038603985 workType "article" @default.