Matches in SemOpenAlex for { <https://semopenalex.org/work/W3038610014> ?p ?o ?g. }
- W3038610014 abstract "Polarisation of the actin cytoskeleton is vital for the collective migration of cells in vivo . During invasive border cell migration in Drosophila , actin polarisation is directly controlled by Hippo pathway components, which reside at contacts between border cells in the cluster. Here we identify, in a genetic screen for deubiquitinating enzymes involved in border cell migration, an essential role for non-stop/USP22 in the expression of Hippo pathway components expanded and merlin ; loss of non-stop function consequently leads to a redistribution of F-actin and the polarity determinant Crumbs, loss of polarised actin protrusions and premature tumbling of the border cell cluster. Non-stop is a component of the Spt-Ada-Gcn5-acetyltransferase (SAGA) transcriptional coactivator complex, but SAGA’s histone acetyltransferase module, which does not bind to expanded or merlin , is dispensable for migration. Taken together, our results uncover novel roles for SAGA-independent non-stop/USP22 in Hippo-mediated collective cell migration, which may help guide studies in other systems where USP22 is necessary for cell motility and invasion." @default.
- W3038610014 created "2020-07-10" @default.
- W3038610014 creator A5001311413 @default.
- W3038610014 creator A5020339333 @default.
- W3038610014 creator A5071216777 @default.
- W3038610014 creator A5076869587 @default.
- W3038610014 date "2020-07-02" @default.
- W3038610014 modified "2023-09-27" @default.
- W3038610014 title "<i>Drosophila</i>USP22/non-stop regulates the Hippo pathway to polarise the actin cytoskeleton during collective border cell migration" @default.
- W3038610014 cites W1509357297 @default.
- W3038610014 cites W1626095167 @default.
- W3038610014 cites W1782202106 @default.
- W3038610014 cites W1940178156 @default.
- W3038610014 cites W1970826261 @default.
- W3038610014 cites W1974694769 @default.
- W3038610014 cites W1975971309 @default.
- W3038610014 cites W1982097676 @default.
- W3038610014 cites W1983096415 @default.
- W3038610014 cites W1984488853 @default.
- W3038610014 cites W1984562849 @default.
- W3038610014 cites W1984768151 @default.
- W3038610014 cites W1985034953 @default.
- W3038610014 cites W1988637028 @default.
- W3038610014 cites W1992938097 @default.
- W3038610014 cites W1993325762 @default.
- W3038610014 cites W1995619799 @default.
- W3038610014 cites W2008297562 @default.
- W3038610014 cites W2009949333 @default.
- W3038610014 cites W2019022091 @default.
- W3038610014 cites W2019109537 @default.
- W3038610014 cites W2039174905 @default.
- W3038610014 cites W2046271059 @default.
- W3038610014 cites W2047531031 @default.
- W3038610014 cites W2049239159 @default.
- W3038610014 cites W2054938702 @default.
- W3038610014 cites W2055900062 @default.
- W3038610014 cites W2057708838 @default.
- W3038610014 cites W2059576320 @default.
- W3038610014 cites W2066521382 @default.
- W3038610014 cites W2069202441 @default.
- W3038610014 cites W2073130902 @default.
- W3038610014 cites W2077112265 @default.
- W3038610014 cites W2078339435 @default.
- W3038610014 cites W2083406057 @default.
- W3038610014 cites W2087575288 @default.
- W3038610014 cites W2090478056 @default.
- W3038610014 cites W2095065858 @default.
- W3038610014 cites W2102316475 @default.
- W3038610014 cites W2102619694 @default.
- W3038610014 cites W2109472768 @default.
- W3038610014 cites W2112369696 @default.
- W3038610014 cites W2114692975 @default.
- W3038610014 cites W2116564906 @default.
- W3038610014 cites W2117265747 @default.
- W3038610014 cites W2119838510 @default.
- W3038610014 cites W2120525124 @default.
- W3038610014 cites W2124593926 @default.
- W3038610014 cites W2129332532 @default.
- W3038610014 cites W2136906483 @default.
- W3038610014 cites W2140676509 @default.
- W3038610014 cites W2142018200 @default.
- W3038610014 cites W2145676008 @default.
- W3038610014 cites W2146724295 @default.
- W3038610014 cites W2147026515 @default.
- W3038610014 cites W2154580523 @default.
- W3038610014 cites W2156657712 @default.
- W3038610014 cites W2157139472 @default.
- W3038610014 cites W2160572702 @default.
- W3038610014 cites W2166666333 @default.
- W3038610014 cites W2168747921 @default.
- W3038610014 cites W2173634841 @default.
- W3038610014 cites W2275559293 @default.
- W3038610014 cites W2337504232 @default.
- W3038610014 cites W2750702413 @default.
- W3038610014 cites W2765506069 @default.
- W3038610014 cites W2793152198 @default.
- W3038610014 cites W2796778437 @default.
- W3038610014 cites W2945647183 @default.
- W3038610014 cites W2952527196 @default.
- W3038610014 cites W2967966233 @default.
- W3038610014 cites W2971034659 @default.
- W3038610014 cites W2981194616 @default.
- W3038610014 cites W2990273204 @default.
- W3038610014 cites W2992444041 @default.
- W3038610014 cites W2997827967 @default.
- W3038610014 cites W4210757594 @default.
- W3038610014 cites W4236395862 @default.
- W3038610014 doi "https://doi.org/10.1101/2020.07.02.177170" @default.
- W3038610014 hasPublicationYear "2020" @default.
- W3038610014 type Work @default.
- W3038610014 sameAs 3038610014 @default.
- W3038610014 citedByCount "0" @default.
- W3038610014 crossrefType "posted-content" @default.
- W3038610014 hasAuthorship W3038610014A5001311413 @default.
- W3038610014 hasAuthorship W3038610014A5020339333 @default.
- W3038610014 hasAuthorship W3038610014A5071216777 @default.
- W3038610014 hasAuthorship W3038610014A5076869587 @default.
- W3038610014 hasBestOaLocation W30386100141 @default.
- W3038610014 hasConcept C104317684 @default.
- W3038610014 hasConcept C125705527 @default.