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• W3038681212 endingPage "2497" @default.
• W3038681212 startingPage "2475" @default.
• W3038681212 abstract "Glycoproteins and glycopeptides are an interesting focus of research, because of their potential use as therapeutic agents, since they are related to carbohydrate-carbohydrate, carbohydrate-protein, and carbohydrate-lipid interactions, which are commonly involved in biological processes. It has been established that natural glycoconjugates could be an important source of templates for the design and development of molecules with therapeutic applications. However, isolating large quantities of glycoconjugates from biological sources with the required purity is extremely complex, because these molecules are found in heterogeneous environments and in very low concentrations. As an alternative to solving this problem, the chemical synthesis of glycoconjugates has been developed. In this context, several methods for the synthesis of glycopeptides in solution and/or solid-phase have been reported. In most of these methods, glycosylated amino acid derivatives are used as building blocks for both solution and solid-phase synthesis. The synthetic viability of glycoconjugates is a critical parameter for allowing their use as drugs to mitigate the impact of microbial resistance and/or cancer. However, the chemical synthesis of glycoconjugates is a challenge, because these molecules possess multiple reaction sites and have a very specific stereochemistry. Therefore, it is necessary to design and implement synthetic routes, which may involve various protection schemes but can be stereoselective, environmentally friendly, and high-yielding. This review focuses on glycopeptide synthesis by recapitulating the progress made over the last 15 years." @default.
• W3038681212 created "2020-07-10" @default.
• W3038681212 creator A5022036632 @default.
• W3038681212 creator A5039834941 @default.
• W3038681212 creator A5083104290 @default.
• W3038681212 creator A5085722674 @default.
• W3038681212 date "2020-12-07" @default.
• W3038681212 modified "2023-10-14" @default.
• W3038681212 title "Development of Strategies for Glycopeptide Synthesis: An Overview on the Glycosidic Linkage" @default.
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