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- W3038795038 startingPage "107844" @default.
- W3038795038 abstract "Changes in dendritic morphology in response to activity have long been thought to be a critical component of how neural circuits develop to properly encode sensory information. Ventral-preferring direction-selective ganglion cells (vDSGCs) have asymmetric dendrites oriented along their preferred direction, and this has been hypothesized to play a critical role in their tuning. Here we report the surprising result that visual experience is critical for the alignment of vDSGC dendrites to their preferred direction. Interestingly, vDSGCs in dark-reared mice lose their inhibition-independent dendritic contribution to direction-selective tuning while maintaining asymmetric inhibitory input. These data indicate that different mechanisms of a cell’s computational abilities can be constructed over development through divergent mechanisms." @default.
- W3038795038 created "2020-07-10" @default.
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- W3038795038 date "2020-06-01" @default.
- W3038795038 modified "2023-10-14" @default.
- W3038795038 title "Visual Experience Influences Dendritic Orientation but Is Not Required for Asymmetric Wiring of the Retinal Direction Selective Circuit" @default.
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- W3038795038 doi "https://doi.org/10.1016/j.celrep.2020.107844" @default.
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