Matches in SemOpenAlex for { <https://semopenalex.org/work/W3038830372> ?p ?o ?g. }
- W3038830372 endingPage "136" @default.
- W3038830372 startingPage "126" @default.
- W3038830372 abstract "Abstract Long‐term stability and biological safety are crucial for translation of 3D‐bioprinting technology into clinical applications. Here, we addressed the long‐term safety and stability issues associated with 3D‐bioprinted constructs comprising a cellulose scaffold and human cells (chondrocytes and stem cells) over a period of 10 months in nude mice. Our findings showed that increasing unconfined compression strength over time significantly improved the mechanical stability of the cell‐containing constructs relative to cell‐free scaffolds. Additionally, the cell‐free constructs exhibited a mean compressive stress and stiffness (compressive modulus) of 0.04 ± 0.05 MPa and 0.14 ± 0.18 MPa, respectively, whereas these values for the cell‐containing constructs were 0.11 ± 0.08 MPa ( p = .019) and 0.53 ± 0.59 MPa ( p = .012), respectively. Moreover, histomorphologic analysis revealed that cartilage formed from the cell‐containing constructs harbored an abundance of proliferating chondrocytes in clusters, and after 10 months, resembled native cartilage. Furthermore, extension of the experiment over the complete lifecycle of the animal model revealed no signs of ossification, fibrosis, necrosis, or implant‐related tumor development in the 3D‐bioprinted constructs. These findings confirm the in vivo biological safety and mechanical stability of 3D‐bioprinted cartilaginous tissues and support their potential translation into clinical applications." @default.
- W3038830372 created "2020-07-10" @default.
- W3038830372 creator A5004046182 @default.
- W3038830372 creator A5006784178 @default.
- W3038830372 creator A5011583053 @default.
- W3038830372 creator A5012009351 @default.
- W3038830372 creator A5021772522 @default.
- W3038830372 creator A5027237758 @default.
- W3038830372 creator A5030442348 @default.
- W3038830372 creator A5038842105 @default.
- W3038830372 creator A5051473199 @default.
- W3038830372 date "2020-07-06" @default.
- W3038830372 modified "2023-10-18" @default.
- W3038830372 title "Long‐term in vivo integrity and safety of <scp>3D</scp> ‐bioprinted cartilaginous constructs" @default.
- W3038830372 cites W11305555 @default.
- W3038830372 cites W1485860760 @default.
- W3038830372 cites W1968749636 @default.
- W3038830372 cites W1989027893 @default.
- W3038830372 cites W1994578076 @default.
- W3038830372 cites W1994903148 @default.
- W3038830372 cites W2010334610 @default.
- W3038830372 cites W2011038175 @default.
- W3038830372 cites W2011056616 @default.
- W3038830372 cites W2012474476 @default.
- W3038830372 cites W2014680491 @default.
- W3038830372 cites W2017013021 @default.
- W3038830372 cites W2021634519 @default.
- W3038830372 cites W2025751503 @default.
- W3038830372 cites W2032804794 @default.
- W3038830372 cites W2036878987 @default.
- W3038830372 cites W2042199568 @default.
- W3038830372 cites W2043081448 @default.
- W3038830372 cites W2047876202 @default.
- W3038830372 cites W2055295229 @default.
- W3038830372 cites W2059128992 @default.
- W3038830372 cites W2068667239 @default.
- W3038830372 cites W2077981163 @default.
- W3038830372 cites W2083652435 @default.
- W3038830372 cites W2093019388 @default.
- W3038830372 cites W2107826536 @default.
- W3038830372 cites W2114697509 @default.
- W3038830372 cites W2139307786 @default.
- W3038830372 cites W2153021040 @default.
- W3038830372 cites W2155588618 @default.
- W3038830372 cites W2164479553 @default.
- W3038830372 cites W2169596632 @default.
- W3038830372 cites W2268331240 @default.
- W3038830372 cites W2513564242 @default.
- W3038830372 cites W2587300986 @default.
- W3038830372 cites W2588746409 @default.
- W3038830372 cites W2610077354 @default.
- W3038830372 cites W2739268315 @default.
- W3038830372 cites W2770750361 @default.
- W3038830372 cites W2773845144 @default.
- W3038830372 cites W4249057311 @default.
- W3038830372 doi "https://doi.org/10.1002/jbm.b.34687" @default.
- W3038830372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32633102" @default.
- W3038830372 hasPublicationYear "2020" @default.
- W3038830372 type Work @default.
- W3038830372 sameAs 3038830372 @default.
- W3038830372 citedByCount "11" @default.
- W3038830372 countsByYear W30388303722021 @default.
- W3038830372 countsByYear W30388303722022 @default.
- W3038830372 countsByYear W30388303722023 @default.
- W3038830372 crossrefType "journal-article" @default.
- W3038830372 hasAuthorship W3038830372A5004046182 @default.
- W3038830372 hasAuthorship W3038830372A5006784178 @default.
- W3038830372 hasAuthorship W3038830372A5011583053 @default.
- W3038830372 hasAuthorship W3038830372A5012009351 @default.
- W3038830372 hasAuthorship W3038830372A5021772522 @default.
- W3038830372 hasAuthorship W3038830372A5027237758 @default.
- W3038830372 hasAuthorship W3038830372A5030442348 @default.
- W3038830372 hasAuthorship W3038830372A5038842105 @default.
- W3038830372 hasAuthorship W3038830372A5051473199 @default.
- W3038830372 hasBestOaLocation W30388303721 @default.
- W3038830372 hasConcept C105702510 @default.
- W3038830372 hasConcept C127413603 @default.
- W3038830372 hasConcept C136229726 @default.
- W3038830372 hasConcept C150903083 @default.
- W3038830372 hasConcept C192562407 @default.
- W3038830372 hasConcept C207001950 @default.
- W3038830372 hasConcept C2779718196 @default.
- W3038830372 hasConcept C2780550940 @default.
- W3038830372 hasConcept C2984185122 @default.
- W3038830372 hasConcept C49892992 @default.
- W3038830372 hasConcept C66938386 @default.
- W3038830372 hasConcept C71924100 @default.
- W3038830372 hasConcept C86803240 @default.
- W3038830372 hasConcept C89429830 @default.
- W3038830372 hasConceptScore W3038830372C105702510 @default.
- W3038830372 hasConceptScore W3038830372C127413603 @default.
- W3038830372 hasConceptScore W3038830372C136229726 @default.
- W3038830372 hasConceptScore W3038830372C150903083 @default.
- W3038830372 hasConceptScore W3038830372C192562407 @default.
- W3038830372 hasConceptScore W3038830372C207001950 @default.
- W3038830372 hasConceptScore W3038830372C2779718196 @default.
- W3038830372 hasConceptScore W3038830372C2780550940 @default.
- W3038830372 hasConceptScore W3038830372C2984185122 @default.