Matches in SemOpenAlex for { <https://semopenalex.org/work/W3038851023> ?p ?o ?g. }
- W3038851023 endingPage "107824" @default.
- W3038851023 startingPage "107824" @default.
- W3038851023 abstract "After fertilization, sperm and oocyte nuclei are rapidly remodeled to form swollen pronuclei (PN) in mammalian zygotes, and the proper formation and function of PN are key to producing totipotent zygotes. However, how mature PN are formed has been unclear. We find that filamentous actin (F-actin) assembles in the PN of mouse zygotes and is required for fully functional PN. The perturbation of nuclear actin dynamics in zygotes results in the misregulation of genes related to genome integrity and abnormal development of mouse embryos. We show that nuclear F-actin ensures DNA damage repair, thus preventing the activation of a zygotic checkpoint. Furthermore, optogenetic control of cofilin nuclear localization reveals the dynamically regulated F-actin nucleoskeleton in zygotes, and its timely disassembly is needed for developmental progression. Nuclear F-actin is a hallmark of totipotent zygotic PN, and the temporal regulation of its polymerized state is necessary for normal embryonic development." @default.
- W3038851023 created "2020-07-10" @default.
- W3038851023 creator A5014359969 @default.
- W3038851023 creator A5016057714 @default.
- W3038851023 creator A5017185998 @default.
- W3038851023 creator A5027520899 @default.
- W3038851023 creator A5035702067 @default.
- W3038851023 creator A5037887239 @default.
- W3038851023 creator A5059163530 @default.
- W3038851023 creator A5060365370 @default.
- W3038851023 creator A5068174476 @default.
- W3038851023 creator A5069418359 @default.
- W3038851023 creator A5070793093 @default.
- W3038851023 creator A5074070999 @default.
- W3038851023 creator A5079569092 @default.
- W3038851023 creator A5087532293 @default.
- W3038851023 date "2020-06-01" @default.
- W3038851023 modified "2023-10-15" @default.
- W3038851023 title "Zygotic Nuclear F-Actin Safeguards Embryonic Development" @default.
- W3038851023 cites W1150470952 @default.
- W3038851023 cites W1923618315 @default.
- W3038851023 cites W1968577363 @default.
- W3038851023 cites W1975484124 @default.
- W3038851023 cites W1997611686 @default.
- W3038851023 cites W2017471472 @default.
- W3038851023 cites W2021341670 @default.
- W3038851023 cites W2026529460 @default.
- W3038851023 cites W2026993081 @default.
- W3038851023 cites W2027111357 @default.
- W3038851023 cites W2033988165 @default.
- W3038851023 cites W2036897871 @default.
- W3038851023 cites W2042718096 @default.
- W3038851023 cites W2045687891 @default.
- W3038851023 cites W2047638806 @default.
- W3038851023 cites W2057429454 @default.
- W3038851023 cites W2060386232 @default.
- W3038851023 cites W2063290334 @default.
- W3038851023 cites W2074536102 @default.
- W3038851023 cites W2077134765 @default.
- W3038851023 cites W2088708165 @default.
- W3038851023 cites W2091570599 @default.
- W3038851023 cites W2099540110 @default.
- W3038851023 cites W2110507524 @default.
- W3038851023 cites W2117249342 @default.
- W3038851023 cites W2123110782 @default.
- W3038851023 cites W2124509928 @default.
- W3038851023 cites W2124599642 @default.
- W3038851023 cites W2124770148 @default.
- W3038851023 cites W2129697720 @default.
- W3038851023 cites W2131271579 @default.
- W3038851023 cites W2136597956 @default.
- W3038851023 cites W2138207763 @default.
- W3038851023 cites W2138655345 @default.
- W3038851023 cites W2164122390 @default.
- W3038851023 cites W2169357646 @default.
- W3038851023 cites W2169456326 @default.
- W3038851023 cites W2179438025 @default.
- W3038851023 cites W2280655495 @default.
- W3038851023 cites W2302043687 @default.
- W3038851023 cites W2343922724 @default.
- W3038851023 cites W2409806253 @default.
- W3038851023 cites W2559661345 @default.
- W3038851023 cites W2576441007 @default.
- W3038851023 cites W2599773520 @default.
- W3038851023 cites W2610933022 @default.
- W3038851023 cites W2611165465 @default.
- W3038851023 cites W2611346822 @default.
- W3038851023 cites W2735035409 @default.
- W3038851023 cites W2736958005 @default.
- W3038851023 cites W2747643030 @default.
- W3038851023 cites W2765937161 @default.
- W3038851023 cites W2768632776 @default.
- W3038851023 cites W2774985751 @default.
- W3038851023 cites W2802090556 @default.
- W3038851023 cites W2808968889 @default.
- W3038851023 cites W2809439755 @default.
- W3038851023 cites W2810436386 @default.
- W3038851023 cites W2905553312 @default.
- W3038851023 cites W2928981533 @default.
- W3038851023 cites W2945941840 @default.
- W3038851023 cites W2949589996 @default.
- W3038851023 cites W2951532637 @default.
- W3038851023 cites W2989650452 @default.
- W3038851023 doi "https://doi.org/10.1016/j.celrep.2020.107824" @default.
- W3038851023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32610125" @default.
- W3038851023 hasPublicationYear "2020" @default.
- W3038851023 type Work @default.
- W3038851023 sameAs 3038851023 @default.
- W3038851023 citedByCount "31" @default.
- W3038851023 countsByYear W30388510232020 @default.
- W3038851023 countsByYear W30388510232021 @default.
- W3038851023 countsByYear W30388510232022 @default.
- W3038851023 countsByYear W30388510232023 @default.
- W3038851023 crossrefType "journal-article" @default.
- W3038851023 hasAuthorship W3038851023A5014359969 @default.
- W3038851023 hasAuthorship W3038851023A5016057714 @default.
- W3038851023 hasAuthorship W3038851023A5017185998 @default.
- W3038851023 hasAuthorship W3038851023A5027520899 @default.