FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3038852914> ?p ?o ?g. }

• W3038852914 endingPage "1239" @default.
• W3038852914 startingPage "1225" @default.
• W3038852914 abstract "Abstract Objective To determine the inflammatory analytes that predict clinical progression and evaluate their performance against biomarkers of neurodegeneration. Methods A longitudinal study of MCI‐AD patients in a Discovery cohort over 15 months, with replication in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) MCI cohort over 36 months. Fifty‐three inflammatory analytes were measured in the CSF and plasma with a RBM multiplex analyte platform. Inflammatory analytes that predict clinical progression on Clinical Dementia Rating Scale‐Sum of Boxes (CDR‐SB) and Mini Mental State Exam scores were assessed in multivariate regression models. To provide context, key analyte results in ADNI were compared against biomarkers of neurodegeneration, hippocampal volume, and CSF neurofilament light (NfL), in receiver operating characteristic (ROC) analyses evaluating highest quartile of CDR‐SB change over two years (≥3 points). Results Cerebrospinal fluid inflammatory analytes in relation to cognitive decline were best described by gene ontology terms, natural killer cell chemotaxis, and endothelial cell apoptotic process and in plasma, extracellular matrix organization, blood coagulation, and fibrin clot formation described the analytes. CSF CCL2 was most robust in predicting rate of cognitive change and analytes that correlated to CCL2 suggest IL‐10 pathway dysregulation. The ROC curves for ≥3 points change in CDR‐SB over 2 years when comparing baseline hippocampal volume, CSF NfL, and CCL2 were not significantly different. Interpretation Baseline levels of immune cell chemotactic cytokine CCL2 in the CSF and IL‐10 pathway dysregulation impact longitudinal cognitive and functional decline in MCI‐AD. CCL2’s utility appears comparable to biomarkers of neurodegeneration in predicting rapid decline." @default.
• W3038852914 created "2020-07-10" @default.
• W3038852914 creator A5008925587 @default.
• W3038852914 creator A5013235362 @default.
• W3038852914 creator A5026245558 @default.
• W3038852914 creator A5029135659 @default.
• W3038852914 creator A5032343032 @default.
• W3038852914 creator A5039612469 @default.
• W3038852914 creator A5042961719 @default.
• W3038852914 creator A5047828457 @default.
• W3038852914 creator A5052130722 @default.
• W3038852914 creator A5056027982 @default.
• W3038852914 creator A5066614378 @default.
• W3038852914 creator A5068679708 @default.
• W3038852914 creator A5071940002 @default.
• W3038852914 date "2020-07-01" @default.
• W3038852914 modified "2023-10-17" @default.
• W3038852914 title "Inflammatory pathway analytes predicting rapid cognitive decline in MCI stage of Alzheimer’s disease" @default.
• W3038852914 cites W1566992315 @default.
• W3038852914 cites W1847168837 @default.
• W3038852914 cites W1934117767 @default.
• W3038852914 cites W1969037225 @default.
• W3038852914 cites W1969353942 @default.
• W3038852914 cites W1970606114 @default.
• W3038852914 cites W1989038107 @default.
• W3038852914 cites W1991952617 @default.
• W3038852914 cites W2004293194 @default.
• W3038852914 cites W2008301592 @default.
• W3038852914 cites W2011356131 @default.
• W3038852914 cites W2015759485 @default.
• W3038852914 cites W2023641365 @default.
• W3038852914 cites W2025935592 @default.
• W3038852914 cites W2035618305 @default.
• W3038852914 cites W2042709868 @default.
• W3038852914 cites W2053953952 @default.
• W3038852914 cites W2079540265 @default.
• W3038852914 cites W2081558146 @default.
• W3038852914 cites W2087243986 @default.
• W3038852914 cites W2089974109 @default.
• W3038852914 cites W2107376426 @default.
• W3038852914 cites W2115462905 @default.
• W3038852914 cites W2118047039 @default.
• W3038852914 cites W2121343862 @default.
• W3038852914 cites W2130373985 @default.
• W3038852914 cites W2135955660 @default.
• W3038852914 cites W2158143414 @default.
• W3038852914 cites W2167645268 @default.
• W3038852914 cites W2171160244 @default.
• W3038852914 cites W2192839519 @default.
• W3038852914 cites W2537623931 @default.
• W3038852914 cites W2564334132 @default.
• W3038852914 cites W2567168289 @default.
• W3038852914 cites W2582524520 @default.
• W3038852914 cites W2594844287 @default.
• W3038852914 cites W2782565874 @default.
• W3038852914 cites W2796088161 @default.
• W3038852914 cites W2798054687 @default.
• W3038852914 cites W2811223038 @default.
• W3038852914 cites W2883326166 @default.
• W3038852914 cites W2911442314 @default.
• W3038852914 cites W2953594239 @default.
• W3038852914 cites W2985460727 @default.
• W3038852914 cites W4288101984 @default.
• W3038852914 doi "https://doi.org/10.1002/acn3.51109" @default.
• W3038852914 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7359114" @default.
• W3038852914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32634865" @default.
• W3038852914 hasPublicationYear "2020" @default.
• W3038852914 type Work @default.
• W3038852914 sameAs 3038852914 @default.
• W3038852914 citedByCount "16" @default.
• W3038852914 countsByYear W30388529142020 @default.
• W3038852914 countsByYear W30388529142021 @default.
• W3038852914 countsByYear W30388529142022 @default.
• W3038852914 countsByYear W30388529142023 @default.
• W3038852914 crossrefType "journal-article" @default.
• W3038852914 hasAuthorship W3038852914A5008925587 @default.
• W3038852914 hasAuthorship W3038852914A5013235362 @default.
• W3038852914 hasAuthorship W3038852914A5026245558 @default.
• W3038852914 hasAuthorship W3038852914A5029135659 @default.
• W3038852914 hasAuthorship W3038852914A5032343032 @default.
• W3038852914 hasAuthorship W3038852914A5039612469 @default.
• W3038852914 hasAuthorship W3038852914A5042961719 @default.
• W3038852914 hasAuthorship W3038852914A5047828457 @default.
• W3038852914 hasAuthorship W3038852914A5052130722 @default.
• W3038852914 hasAuthorship W3038852914A5056027982 @default.
• W3038852914 hasAuthorship W3038852914A5066614378 @default.
• W3038852914 hasAuthorship W3038852914A5068679708 @default.
• W3038852914 hasAuthorship W3038852914A5071940002 @default.
• W3038852914 hasBestOaLocation W30388529141 @default.
• W3038852914 hasConcept C126322002 @default.
• W3038852914 hasConcept C143998085 @default.
• W3038852914 hasConcept C151730666 @default.
• W3038852914 hasConcept C203014093 @default.
• W3038852914 hasConcept C2778373026 @default.
• W3038852914 hasConcept C2779134260 @default.
• W3038852914 hasConcept C2779343474 @default.
• W3038852914 hasConcept C2779483572 @default.
• W3038852914 hasConcept C2780906993 @default.

• next