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- W3038895989 abstract "Abstract Myocardial ischaemia reperfusion (I/R) injury is one of the leading causes of coronary artery disease‐associated morbidity and mortality. While different strategies have been used to limit I/R injuries, cardiac functions often do not recover to the normal level as anticipated. Recent studies have pointed to important roles of long noncoding RNAs (lncRNAs) in the development of myocardial I/R injury. LncRNA is a class of RNA molecules of more than 200 nucleotides in length which are not translated into proteins. I/R causes dysregulation of lncRNA expression in cardiomyocytes, thereby affecting multiple cellular functions including mitochondrial homeostasis, apoptosis, necrosis and autophagy, suggesting that manipulating lncRNAs may be of great potential in counteracting I/R injury‐induced myocardial dysfunctions. In this review, we provide an updated summary on our knowledge about contributions of lncRNAs to the development of I/R injury, with an emphasis on the functional links between several well established cardiac lncRNAs and regulation of cellular outcomes post I/R." @default.
- W3038895989 created "2020-07-10" @default.
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- W3038895989 date "2020-08-11" @default.
- W3038895989 modified "2023-10-01" @default.
- W3038895989 title "Long noncoding RNAs: Important participants and potential therapeutic targets for myocardial ischaemia reperfusion injury" @default.
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- W3038895989 doi "https://doi.org/10.1111/1440-1681.13375" @default.
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