Matches in SemOpenAlex for { <https://semopenalex.org/work/W3038901887> ?p ?o ?g. }
- W3038901887 endingPage "275" @default.
- W3038901887 startingPage "275" @default.
- W3038901887 abstract "Feed efficiency (FE) is an economically important trait. Thus, reliable predictors would help to reduce the production cost and provide sustainability to the pig industry. We carried out metabolome-transcriptome integration analysis on 40 purebred Duroc and Landrace uncastrated male pigs to identify potential gene-metabolite interactions and explore the molecular mechanisms underlying FE. To this end, we applied untargeted metabolomics and RNA-seq approaches to the same animals. After data quality control, we used a linear model approach to integrate the data and find significant differently correlated gene-metabolite pairs separately for the breeds (Duroc and Landrace) and FE groups (low and high FE) followed by a pathway over-representation analysis. We identified 21 and 12 significant gene-metabolite pairs for each group. The valine-leucine-isoleucine biosynthesis/degradation and arginine-proline metabolism pathways were associated with unique metabolites. The unique genes obtained from significant metabolite-gene pairs were associated with sphingolipid catabolism, multicellular organismal process, cGMP, and purine metabolic processes. While some of the genes and metabolites identified were known for their association with FE, others are novel and provide new avenues for further research. Further validation of genes, metabolites, and gene-metabolite interactions in larger cohorts will elucidate the regulatory mechanisms and pathways underlying FE." @default.
- W3038901887 created "2020-07-10" @default.
- W3038901887 creator A5033024779 @default.
- W3038901887 creator A5036656399 @default.
- W3038901887 creator A5052557605 @default.
- W3038901887 date "2020-07-06" @default.
- W3038901887 modified "2023-10-18" @default.
- W3038901887 title "Integrative Analysis of Metabolomic and Transcriptomic Profiles Uncovers Biological Pathways of Feed Efficiency in Pigs" @default.
- W3038901887 cites W1790281615 @default.
- W3038901887 cites W1898349335 @default.
- W3038901887 cites W1939842549 @default.
- W3038901887 cites W1965266937 @default.
- W3038901887 cites W2006879847 @default.
- W3038901887 cites W2016886772 @default.
- W3038901887 cites W2031691550 @default.
- W3038901887 cites W2038102905 @default.
- W3038901887 cites W2038203316 @default.
- W3038901887 cites W2038652783 @default.
- W3038901887 cites W2038963685 @default.
- W3038901887 cites W2042820257 @default.
- W3038901887 cites W2046645216 @default.
- W3038901887 cites W2057383604 @default.
- W3038901887 cites W2064857342 @default.
- W3038901887 cites W2064987217 @default.
- W3038901887 cites W2066668523 @default.
- W3038901887 cites W2085186237 @default.
- W3038901887 cites W2097929428 @default.
- W3038901887 cites W2107775053 @default.
- W3038901887 cites W2124649441 @default.
- W3038901887 cites W2143350291 @default.
- W3038901887 cites W2146512944 @default.
- W3038901887 cites W2150064414 @default.
- W3038901887 cites W2152239989 @default.
- W3038901887 cites W2158721137 @default.
- W3038901887 cites W2165280589 @default.
- W3038901887 cites W2169589032 @default.
- W3038901887 cites W2256781010 @default.
- W3038901887 cites W2264407089 @default.
- W3038901887 cites W2287154159 @default.
- W3038901887 cites W2322646064 @default.
- W3038901887 cites W2344526199 @default.
- W3038901887 cites W2346723591 @default.
- W3038901887 cites W2401898117 @default.
- W3038901887 cites W2410793532 @default.
- W3038901887 cites W2430370065 @default.
- W3038901887 cites W2436270747 @default.
- W3038901887 cites W2582679467 @default.
- W3038901887 cites W2592589959 @default.
- W3038901887 cites W2601298138 @default.
- W3038901887 cites W2614322045 @default.
- W3038901887 cites W2622197569 @default.
- W3038901887 cites W2765999833 @default.
- W3038901887 cites W2790652923 @default.
- W3038901887 cites W2797513002 @default.
- W3038901887 cites W2803664483 @default.
- W3038901887 cites W2884785624 @default.
- W3038901887 cites W2892114797 @default.
- W3038901887 cites W2901939010 @default.
- W3038901887 cites W2909612079 @default.
- W3038901887 cites W2915040329 @default.
- W3038901887 cites W2917791795 @default.
- W3038901887 cites W2954051762 @default.
- W3038901887 cites W2963421754 @default.
- W3038901887 cites W2966517397 @default.
- W3038901887 cites W2978238105 @default.
- W3038901887 cites W3000617814 @default.
- W3038901887 cites W3007663481 @default.
- W3038901887 cites W3037194905 @default.
- W3038901887 cites W4237268061 @default.
- W3038901887 cites W4383997435 @default.
- W3038901887 doi "https://doi.org/10.3390/metabo10070275" @default.
- W3038901887 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7408121" @default.
- W3038901887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32640603" @default.
- W3038901887 hasPublicationYear "2020" @default.
- W3038901887 type Work @default.
- W3038901887 sameAs 3038901887 @default.
- W3038901887 citedByCount "8" @default.
- W3038901887 countsByYear W30389018872021 @default.
- W3038901887 countsByYear W30389018872022 @default.
- W3038901887 countsByYear W30389018872023 @default.
- W3038901887 crossrefType "journal-article" @default.
- W3038901887 hasAuthorship W3038901887A5033024779 @default.
- W3038901887 hasAuthorship W3038901887A5036656399 @default.
- W3038901887 hasAuthorship W3038901887A5052557605 @default.
- W3038901887 hasBestOaLocation W30389018871 @default.
- W3038901887 hasConcept C104317684 @default.
- W3038901887 hasConcept C135870905 @default.
- W3038901887 hasConcept C150194340 @default.
- W3038901887 hasConcept C162317418 @default.
- W3038901887 hasConcept C192989942 @default.
- W3038901887 hasConcept C21565614 @default.
- W3038901887 hasConcept C2777477808 @default.
- W3038901887 hasConcept C54355233 @default.
- W3038901887 hasConcept C55493867 @default.
- W3038901887 hasConcept C60644358 @default.
- W3038901887 hasConcept C62231903 @default.
- W3038901887 hasConcept C70721500 @default.
- W3038901887 hasConcept C86803240 @default.