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- W3038919630 abstract "Abstract Puberty is the process of achieving the capacity for reproduction and depends upon increased gonadotropin-releasing hormone (GnRH) secretion. Neurons in the arcuate nucleus of the hypothalamus (ARC) coexpressing kisspeptin, neurokinin B (NKB), and dynorphin (i.e. KNDy cells) are critical for puberty onset. In humans and livestock, mistimed puberty has negative consequences for health and production, respectively. Puberty is largely impacted by genetics and genes associated with its timing include those for kisspeptin and NKB. Epigenetic modification of genes and transcriptional activity also influence puberty onset. Adequate nutrition is required for normal puberty onset and the hormone leptin links metabolic status and puberty. Leptin acts through ARC neurons reciprocally connected with KNDy neurons that transduce nutritional signals into inputs influencing GnRH neurons. Further work using multiple animal models, including agriculturally important species, will be necessary for understanding the neural mechanisms underlying puberty onset and the problems associated with mistimed puberty." @default.
- W3038919630 created "2020-07-10" @default.
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- W3038919630 date "2020-10-01" @default.
- W3038919630 modified "2023-09-23" @default.
- W3038919630 title "The choreography of puberty: Evidence from sheep and other agriculturally important species" @default.
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- W3038919630 doi "https://doi.org/10.1016/j.coemr.2020.06.008" @default.
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